Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Stellor Nlandu-Khodo"'
Autor:
Merve Kayhan, Judith Vouillamoz, Daymé Gonzalez Rodriguez, Milica Bugarski, Yasutaka Mitamura, Julia Gschwend, Christoph Schneider, Andrew Hall, David Legouis, Cezmi A. Akdis, Leary Peter, Hubert Rehrauer, Leslie Gewin, Roland H. Wenger, Stellor Nlandu Khodo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Excessive TGF-β signaling and mitochondrial dysfunction fuel chronic kidney disease (CKD) progression. However, inhibiting TGF-β failed to impede CKD in humans. The proximal tubule (PT), the most vulnerable renal segment, is packed with gi
Externí odkaz:
https://doaj.org/article/e2750f6de0d049b9a4d018aabbf94898
Autor:
Andreas D. Kistler, Rudolf P. Wüthrich, Malte Kölling, Felix Beuschlein, Albina Nowak, Johan M. Lorenzen, Stellor Nlandu-Khodo, George Haddad
Publikováno v:
Journal of Medical Genetics. 59:279-286
BackgroundFabry disease is a rare X-linked lysosomal storage disease caused by mutations in the galactosidase α gene. Deficient activity of α-galactosidase A leads to glycosphingolipid accumulations in multiple organs. Circular RNAs represent stron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34376a95ec19ee0c535a0f0edecc05e0
https://doi.org/10.1136/jmedgenet-2020-107086
https://doi.org/10.1136/jmedgenet-2020-107086
Publikováno v:
Pflugers Archiv : European journal of physiology. 474(8)
Renal erythropoietin (Epo)-producing (REP) cells represent a rare and incompletely understood cell type. REP cells are fibroblast-like cells located in close proximity to blood vessels and tubules of the corticomedullary border region. Epo mRNA in RE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1b1877c79b24c7a078258b14908c605
https://pubmed.ncbi.nlm.nih.gov/35750861
https://pubmed.ncbi.nlm.nih.gov/35750861
Autor:
Wei Shi, Timothy M. Sullivan, Jeff Reese, Katharina Hopp, Christa Gaskill, Dwight J. Klemm, Stellor Nlandu Khodo, Kevin C. Ess, Julie W. Harral, Leslie Gewin, Megan E. Summers, Surekha Neelisetty, Valentina Kon, Susan M. Majka
Publikováno v:
American Journal of Physiology-Renal Physiology. 317:F1201-F1210
Tuberous sclerosis complex 2 (TSC2), or tuberin, is a pivotal regulator of the mechanistic target of rapamycin signaling pathway that controls cell survival, proliferation, growth, and migration. Loss of Tsc2 function manifests in organ-specific cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::897e906f457d783ea32aec04c811c511
https://doi.org/10.1152/ajprenal.00629.2018
https://doi.org/10.1152/ajprenal.00629.2018
Autor:
Kenyi Saito-Diaz, Ethan Lee, Tessa Huffstater, Robert S. McMahon, Balakuntalam S. Kasinath, Surekha Neelisetty, Yosuke Osaki, Alla V. Ivanova, Makoto Mark Taketo, Jane Tonello, Raymond C. Harris, Lauren Scarfe, Stellor Nlandu-Khodo, Mark P. deCaestecker, Melanie Phillips-Mignemi, Haichun Yang, Leslie Gewin
Publikováno v:
JCI Insight
The Wnt/β-catenin signaling pathway plays an important role in renal development and is reexpressed in the injured kidney and other organs. β-Catenin signaling is protective in acute kidney injury (AKI) through actions on the proximal tubule, but t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06fe16ed563afda4a4c7dd31fe549630
https://doi.org/10.1172/jci.insight.135454
https://doi.org/10.1172/jci.insight.135454
Autor:
Peter E. Clark, Surekha Neelisetty, Agnes B. Fogo, Marika Manolopoulou, Haichun Yang, Melanie Phillips, Ethan Lee, Raymond C. Harris, Leslie Gewin, Gautam Bhave, Lauren May, Makoto Mark Taketo, Stellor Nlandu-Khodo
Publikováno v:
Journal of the American Society of Nephrology. 28:3490-3503
The TGF-β and Wnt/β-catenin pathways have important roles in modulating CKD, but how these growth factors affect the epithelial response to CKD is not well studied. TGF-β has strong profibrotic effects, but this pleiotropic factor has many differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222ccda91563497136893a88525690f5
https://doi.org/10.1681/asn.2016121351
https://doi.org/10.1681/asn.2016121351
Autor:
Leslie S, Gewin, Megan E, Summers, Julie W, Harral, Christa F, Gaskill, Stellor Nlandu, Khodo, Surekha, Neelisetty, Timothy M, Sullivan, Katharina, Hopp, J Jeffrey, Reese, Dwight J, Klemm, Valentina, Kon, Kevin C, Ess, Wei, Shi, Susan M, Majka
Publikováno v:
Am J Physiol Renal Physiol
Tuberous sclerosis complex 2 (TSC2), or tuberin, is a pivotal regulator of the mechanistic target of rapamycin signaling pathway that controls cell survival, proliferation, growth, and migration. Loss of Tsc2 function manifests in organ-specific cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0f71565bf13d546ff918aa30509015d1
https://pubmed.ncbi.nlm.nih.gov/31461347
https://pubmed.ncbi.nlm.nih.gov/31461347
Autor:
David K. Flaherty, Catherine E. Alford, Marika Manolopoulou, Brittany K. Matlock, Ken S. Lau, Melanie Phillips-Mignemi, Leslie Gewin, Alan J. Simmons, Stellor Nlandu-Khodo, Alla V. Ivanova
Publikováno v:
Am J Physiol Renal Physiol
Flow cytometry studies on injured kidney tubules are complicated by the low yield of nucleated single cells. Furthermore, cell-specific responses such as cell cycle dynamics in vivo have conventionally relied on indirect immunohistochemistry and prox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0917d16d57b26ad1ad18e38e3659f91
https://pubmed.ncbi.nlm.nih.gov/30759021
https://pubmed.ncbi.nlm.nih.gov/30759021
Autor:
Luke G. Woodbury, Raymond C. Harris, Surekha Neelisetty, Leslie Gewin, Stellor Nlandu Khodo, Elizabeth Green, Roy Zent
Publikováno v:
American Journal of Physiology-Renal Physiology. 310:F499-F510
Transforming growth factor-β (TGF-β) and hepatocyte growth factor (HGF) play key roles in regulating the response to renal injury but are thought to mediate divergent effects on cell behavior. However, how TGF-β signaling alters the response to HG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb79ebc738d537fa965a0ce706b682e
https://doi.org/10.1152/ajprenal.00446.2015
https://doi.org/10.1152/ajprenal.00446.2015
Autor:
Leslie Gewin, Aolei Niu, Jessica M. Overstreet, Raymond C. Harris, Yan Li, Xiaofeng Fan, Guan-Nan Jin, Suwan Wang, Sungjin Chung, Stellor Nlandu Khodo, Kensuke Sasaki, Ming-Zhi Zhang, Yinqiu Wang
Publikováno v:
JCI Insight. 3
TGF-β signals through a receptor complex composed of 2 type I and 2 type II (TGF-βRII) subunits. We investigated the role of macrophage TGF-β signaling in fibrosis after AKI in mice with selective monocyte/macrophage TGF-βRII deletion (macrophage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d16a39b63a4a90e15a93bc7a7fd7eee
https://doi.org/10.1172/jci.insight.123563
https://doi.org/10.1172/jci.insight.123563