Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Stellar Boo"'
Autor:
Nuno M. Coelho, Pamma D. Arora, Sander van Putten, Stellar Boo, Petar Petrovic, Alyna Xue Lin, Boris Hinz, Christopher A. McCulloch
Publikováno v:
Cell Reports, Vol 18, Iss 7, Pp 1774-1790 (2017)
Discoidin domain receptor 1 (DDR1) is a tyrosine kinase collagen adhesion receptor that mediates cell migration through association with non-muscle myosin IIA (NMIIA). Because DDR1 is implicated in cancer fibrosis, we hypothesized that DDR1 interacts
Externí odkaz:
https://doaj.org/article/0b74688b3c2849c58cd32d12102db742
Autor:
Elena Godbout, Dong Ok Son, Stephanie Hume, Stellar Boo, Vincent Sarrazy, Sophie Clément, Andras Kapus, Bernhard Wehrle-Haller, Leena Bruckner-Tuderman, Cristina Has, Boris Hinz
Publikováno v:
Cells, Vol 9, Iss 12, p 2702 (2020)
We identify the focal adhesion protein kindlin-2 as player in a novel mechanotransduction pathway that controls profibrotic cardiac fibroblast to myofibroblast activation. Kindlin-2 is co-upregulated with the myofibroblast marker α-smooth muscle act
Externí odkaz:
https://doaj.org/article/8acc59e3adfa4e7bb9bedafb37f70e51
Autor:
Mei Sun, Ryo Ishii, Kenichi Okumura, Adrienn Krauszman, Siegfried Breitling, Olga Gomez, Aleksander Hinek, Stellar Boo, Boris Hinz, Kim A. Connelly, Wolfgang M. Kuebler, Mark K. Friedberg
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 7 (2018)
BackgroundDevelopment of right ventricular (RV) hypertension eventually contributes to RV and left ventricular (LV) myocardial fibrosis and dysfunction. The molecular mechanisms are not fully elucidated. Methods and ResultsPulmonary artery banding wa
Externí odkaz:
https://doaj.org/article/7a64449e06e2477094a94fd1704b8a48
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0121049 (2015)
Adiponectin, circulating levels of which are reduced in obesity and diabetes, mediates cardiac extracellular matrix (ECM) remodeling in response to pressure overload (PO). Here, we performed a detailed temporal analysis of progressive cardiac ECM rem
Externí odkaz:
https://doaj.org/article/123e1a431c784f95931994548adcdd54
Autor:
Maya Ezzo, Nuno M. Coelho, Stellar Boo, Sander van Putten, David W. Griggs, Boris Hinz, Christopher A. McCulloch, Nina Noskovičová, Ronen Schuster, Peter G. Ruminski, Anne Koehler
Publikováno v:
Nature Biomedical Engineering. 5:1437-1456
The fibrotic encapsulation of implants involves the mechanical activation of myofibroblasts and of pro-fibrotic transforming growth factor beta 1 (TGF-β1). Here, we show that both softening of the implant surfaces and inhibition of the activation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005d92d382f815aae7f280c7eb3f9ade
https://doi.org/10.1038/s41551-021-00722-z
https://doi.org/10.1038/s41551-021-00722-z
Autor:
Petar Petrovic, Boris Hinz, Christopher A. McCulloch, Pamma D. Arora, Nuno M. Coelho, Stellar Boo, Sander van Putten, Alyna Xue Lin
Publikováno v:
Cell Reports, Vol 18, Iss 7, Pp 1774-1790 (2017)
Discoidin domain receptor 1 (DDR1) is a tyrosine kinase collagen adhesion receptor that mediates cell migration through association with non-muscle myosin IIA (NMIIA). Because DDR1 is implicated in cancer fibrosis, we hypothesized that DDR1 interacts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb594589627646635f9fc701a4b8a60
https://doi.org/10.1016/j.celrep.2017.01.061
https://doi.org/10.1016/j.celrep.2017.01.061
Autor:
Mohit Kapoor, Kjetil Ask, Brian Wu, Stellar Boo, Pardis Pakshir, Boris Hinz, Henna Karvonen, Michael Glogauer, Riitta Kaarteenaho, Elizabeth Cambridge, Monika Lodyga, Melanie Kiebalo
Publikováno v:
Science Signaling. 12
Macrophages contribute to the activation of fibroblastic cells into myofibroblasts, which secrete collagen and contract the collagen matrix to acutely repair injured tissue. Persistent myofibroblast activation leads to the accumulation of fibrotic sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4e88fa4ffe948ab68be7d3d22ec635
https://doi.org/10.1126/scisignal.aao3469
https://doi.org/10.1126/scisignal.aao3469
Autor:
Stellar Boo, Krystale De Freitas, Rohan John, Mingliang Lu, Ahmad M. Sidiqi, Qinghong Dan, Janne Folke Bialik, Xiaolin He, Darren A. Yuen, Andrew Advani, Stephen G. Szeto, Masahiro Narimatsu, Jeffrey L. Wrana, Syamantak Majumder, Lauren Chan, Boris Hinz, Andras Kapus, Monica F. Tolosa
Publikováno v:
Journal of the American Society of Nephrology. 27:3117-3128
Like many organs, the kidney stiffens after injury, a process that is increasingly recognized as an important driver of fibrogenesis. Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are related mechanosensory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3495f6f8f1c4e3d4746f5476f47c7b46
https://doi.org/10.1681/asn.2015050499
https://doi.org/10.1681/asn.2015050499
Autor:
Paul M N Werker, Bram Piersma, Ruud A. Bank, Boris Hinz, Saskia de Rond, Stellar Boo, Marike van Beuge
Publikováno v:
The American Journal of Pathology, 185(12), 3326-3337. ELSEVIER SCIENCE INC
Dupuytren disease is a fibrotic disorder characterized by contraction of myofibroblast-rich cords and nodules in the hands. The Hippo member Yes-associated protein 1 (YAP1) is activated by tissue stiffness and the profibro tic transforming growth fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca58d655150232de87e8fa59befbb6f
https://doi.org/10.1016/j.ajpath.2015.08.011
https://doi.org/10.1016/j.ajpath.2015.08.011
Autor:
Adrienn Krauszman, Boris Hinz, Stellar Boo, Wolfgang M. Kuebler, Ryo Ishii, Kenichi Okumura, Mei Sun, Aleksander Hinek, Siegfried Breitling, Mark K. Friedberg, Olga Gómez, Kim A. Connelly
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Development of right ventricular ( RV ) hypertension eventually contributes to RV and left ventricular ( LV ) myocardial fibrosis and dysfunction. The molecular mechanisms are not fully elucidated. Methods and Results Pulmonary artery band
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf426dd6b5592a69fc2135e358df89f
https://doi.org/10.1161/jaha.117.007928
https://doi.org/10.1161/jaha.117.007928