Assessing testicular germ cell DNA damage in the comet assay; introduction of a proof‐of‐concept

Autor: Yvette Dirven, Dag Markus Eide, Erika Witasp Henriksson, Rune Hjorth, Anoop Kumar Sharma, Anne Graupner, Gunnar Brunborg, Jarle Ballangby, Anne Mette Zenner Boisen, Stellan Swedmark, Kristine Bjerve Gützkow, Ann‐Karin Olsen

Publikováno v: Dirven, Y, Eide, D M, Henriksson, E W, Hjorth, R, Sharma, A K, Graupner, A, Brunborg, G, Ballangby, J, Boisen, A M Z, Swedmark, S, Gützkow, K B & Olsen, A K 2023, ' Assessing testicular germ cell DNA damage in the comet assay; introduction of a proof-of-concept ', Environmental and Molecular Mutagenesis, vol. 64, no. 2, pp. 88-104 . https://doi.org/10.1002/em.22527
Environmental and Molecular Mutagenesis

The in vivo comet assay is widely used to measure genotoxicity; however, the current OECD test guideline (TG 489) does not recommend using the assay to assess testicular germ cells, due to the presence of testicular somatic cells. An adapted approach

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d2c026e70ba30158a2077b027cc2a5
https://doi.org/10.1002/em.22527

Mice Lacking 12/15-Lipoxygenase Have Attenuated Airway Allergic Inflammation and Remodeling

Autor: Kristina Rydell-Törmänen, Jonas S. Erjefält, Hans-Erik Claesson, Cecilia Andersson, Stellan Swedmark, Anneli Hällgren

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 39:648-656

Arachidonate 15-lipoxygenase (LO)-1 has been implicated in allergic inflammation and asthma. The overall effect of 15-LO in allergic inflammation in vivo is, however, unclear. This study investigates systemic allergen sensitization and local allergic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70f78cfd86100798cb3f87b60cfa9de
https://doi.org/10.1165/rcmb.2007-0443oc

Involvement of Liver Carboxylesterases in the In Vitro Metabolism of Lidocaine

Autor: Stefan E.H. Alexson, Margareta A. Diczfalusy, Magnus M. Halldin, Stellan Swedmark

Publikováno v: Drug Metabolism and Disposition. 30:643-647

Although lidocaine has been used clinically for more than half a century, the metabolism has still not been fully elucidated. In the present study we have addressed the involvement of hydroxylations, deethylations, and ester hydrolysis in the metabol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f1f68e31766f2c587734a8ce887a61
https://doi.org/10.1124/dmd.30.6.643

Identification of a new subfamily of sulphotransferases: cloning and characterization of canine SULT1D1

Autor: Carrie TSOI, Charles N. FALANY, Ralf MORGENSTERN, Stellan SWEDMARK

Publikováno v: Biochemical Journal. 356:891-897

Sulphation is an important conjugation pathway in drug metabolism that has been studied in several species including humans. However, few studies have been performed using the dog as a subject. In this report we describe the cloning and characterizat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7013662b07a7e53a094046c055ca5af9
https://doi.org/10.1042/bj3560891

Studies on glutathione transferases belonging to class pi in cell lines with different capacities for conjugating (+)-7β,8α-dihydroxy-9α, l0α-oxy-7,8,9,10-tetrahy drobenzo[a] pyrene

Autor: Dag Jenssen, Lennart Romert, Stellan Swedmark, Ralf Morgenstern

Publikováno v: Carcinogenesis. 13:1719-1723

The glutathione transferases (GST) belonging to class pi are primarily responsible for the intracellular detoxification of the highly mutagenic and carcinogenic compound (+)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-oxy-7,8,9,10-tetrahydrobenzo[a]p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::213f13bf59eac22dced8cc845c4c6d3e
https://doi.org/10.1093/carcin/13.10.1719