The dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non‐coding RNA and synonymous mutations

Autor: Sven Diederichs, Lorenz Bartsch, Julia C Berkmann, Karin Fröse, Jana Heitmann, Caroline Hoppe, Deetje Iggena, Danny Jazmati, Philipp Karschnia, Miriam Linsenmeier, Thomas Maulhardt, Lino Möhrmann, Johannes Morstein, Stella V Paffenholz, Paula Röpenack, Timo Rückert, Ludger Sandig, Maximilian Schell, Anna Steinmann, Gjendine Voss, Jacqueline Wasmuth, Maria E Weinberger, Ramona Wullenkord

Publikováno v: EMBO Molecular Medicine, Vol 8, Iss 5, Pp 442-457 (2016)

Abstract Cancer is a disease of the genome caused by oncogene activation and tumor suppressor gene inhibition. Deep sequencing studies including large consortia such as TCGA and ICGC identified numerous tumor‐specific mutations not only in protein�

Externí odkaz: https://doaj.org/article/f493a237e7b24fe5b81baf1eb7e2e60f

Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging

Autor: Ruzhica Bogeska, Ana-Matea Mikecin, Paul Kaschutnig, Malak Fawaz, Marleen Büchler-Schäff, Duy Le, Miguel Ganuza, Angelika Vollmer, Stella V. Paffenholz, Noboru Asada, Esther Rodriguez-Correa, Felix Frauhammer, Florian Buettner, Melanie Ball, Julia Knoch, Sina Stäble, Dagmar Walter, Amelie Petri, Martha J. Carreño-Gonzalez, Vinona Wagner, Benedikt Brors, Simon Haas, Daniel B. Lipka, Marieke A.G. Essers, Vivienn Weru, Tim Holland-Letz, Jan-Philipp Mallm, Karsten Rippe, Stephan Krämer, Matthias Schlesner, Shannon McKinney Freeman, Maria Carolina Florian, Katherine Y. King, Paul S. Frenette, Michael A. Rieger, Michael D. Milsom

Publikováno v: Cell Stem Cell

Hematopoietic stem cells (HSCs) mediate regeneration of the hematopoietic system following injury, such as following infection or inflammation. These challenges impair HSC function, but whether this functional impairment extends beyond the duration o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87801e0ceaae617b38b7e25475a939dd
https://pubmed.ncbi.nlm.nih.gov/35931026

Perception of the 2020 SARS-CoV-2 pandemic among medical professionals in Germany: results from a nationwide online survey

Autor: Lukas Martin, Sven H. Loosen, Christoph Roderburg, Mark Luedde, Miriam Haverkamp, Stella V Paffenholz, Axel Heidenreich, Arne Peine, Gernot Marx, Pia Paffenholz, Martin Hellmich, Tom Luedde, Christian Trautwein

Publikováno v: Emerging Microbes & Infections
article-version (VoR) Version of Record
Emerging Microbes & Infections : EMI 9(1), 1590-1599 (2020). doi:10.1080/22221751.2020.1785951

Emerging Microbes & Infections : EMI 9(1), 1590-1599 (2020). doi:10.1080/22221751.2020.1785951
Published by Taylor & Francis, London

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a741f0c8ff81845313618dce1e467cdf
https://doi.org/10.1080/22221751.2020.1785951

The dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non‐coding RNA and synonymous mutations

Autor: Karin Fröse, Miriam Linsenmeier, Julia C. Berkmann, Jana Heitmann, Lino Möhrmann, Gjendine Voss, Philipp Karschnia, Sven Diederichs, Deetje Iggena, Caroline Hoppe, Lorenz Bartsch, Maria E Weinberger, Paula Röpenack, Johannes Morstein, Timo Rückert, Anna Steinmann, Stella V Paffenholz, Ludger Sandig, Ramona Wullenkord, Jacqueline Wasmuth, Danny Jazmati, Maximilian Schell, Thomas Maulhardt

Publikováno v: Diederichs, S, Bartsch, L, Berkmann, J C, Fröse, K, Heitmann, J, Hoppe, C, Iggena, D, Jazmati, D, Karschnia, P, Linsenmeier, M, Maulhardt, T, Möhrmann, L, Morstein, J, Paffenholz, S V, Röpenack, P, Rückert, T, Sandig, L, Schell, M, Steinmann, A, Voss, G, Wasmuth, J, Weinberger, M E & Wullenkord, R 2016, ' The dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non-coding RNA and synonymous mutations ', EMBO Molecular Medicine, vol. 8, no. 5, pp. 442-57 . https://doi.org/10.15252/emmm.201506055
EMBO Molecular Medicine

Cancer is a disease of the genome caused by oncogene activation and tumor suppressor gene inhibition. Deep sequencing studies including large consortia such as TCGA and ICGC identified numerous tumor‐specific mutations not only in protein‐coding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e689fba1ebc81913434045610d3eb18a
https://doi.org/10.15252/emmm.201506055

Oncogenic Mutations in XPO1 Promote Lymphoid Transformation By Altering Nuclear/Cytoplasmic Localization of NFκB Signaling Intermediates

Autor: Justin Taylor, Stanley Chun-Wei Lee, Xiao Jing Zhang, Alexander V Penson, Jose Antonio Rodriguez, Lillian Bitner, Matthew T. Chang, Myriam Boukhali, Stella V Paffenholz, Rajesh K. Soni, Barry S. Taylor, Christina Marcelus, Young Rock Chung, Omar Abdel-Wahab, Akihide Yoshimi, Wilhelm Haas, Ronald C. Hendrickson

Publikováno v: Blood. 130:879-879

Genomic analyses across cancer have identified recurrent somatic mutations in XPO1, which encodes a major nuclear cytoplasmic transport protein responsible for exporting a broad range of cargo proteins from the nucleus to the cytoplasm. Specifically,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63fe3a140d7d8872a694918d5bf8393f
https://doi.org/10.1182/blood.v130.suppl_1.879.879