Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Stella S. Yu"'
Autor:
Thomas D. Penning, Nizal S. Chandrakumar, Barbara B. Chen, Helen Y. Chen, Bipin N. Desai, Stevan W. Djuric, Stephen H. Docter, Alan F. Gasiecki, Richard A. Haack, Julie M. Miyashiro, Mark A. Russell, Stella S. Yu, David G. Corley, Richard C. Durley, Brian F. Kilpatrick, Barry L. Parnas, Leslie J. Askonas, James K. Gierse, Elizabeth I. Harding, Maureen K. Highkin, James F. Kachur, Suzanne H. Kim, Gwen G. Krivi, Doreen Villani-Price, E. Yvonne Pyla, Walter G. Smith, Nayereh S. Ghoreishi-Haack
Publikováno v:
Journal of Medicinal Chemistry. 43:721-735
Leukotriene B(4) (LTB(4)) is a pro-inflammatory mediator that has been implicated in the pathogenesis of a number of diseases including inflammatory bowel disease (IBD) and psoriasis. Since the action of LTA(4) hydrolase is the rate-limiting step for
Autor:
Gwen Grabowski Krivi, E.Yvonne Pyla, Stevan W. Djuric, Thomas D. Penning, Richard A. Haack, Leslie J Askonas, Stella S. Yu, Marshall L. Michener
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2517-2522
The hydroxamic acid-containing peptide kelatorphan, a known inhibitor of enkephalin-degrading enzymes, is a potent, non-competitive inhibitor of leukotriene A4 (LTA4) hydrolase. Analogs of kelatorphan were prepared and several significantly and selec
Autor:
D. J. Fretland, D. L. Widomski, Timothy S. Gaginella, James F. Kachur, T.J. Maziasz, C. P. Anglin, B.S. Tsai, Stella S. Yu, Tadimeti S. Rao, R. E. Walsh, R H Keith, Stephen H Docter, Stevan W. Djuric, D Villani-Price
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:811-816
The Structure Activity Relationship (SAR) studies leading to the identification of a novel high potency Leukotriene B4 receptor antagonist SC-53228 are delineated. This compound shows excelled pharmacodynamic efficacy in animal models of inflammatory
Autor:
M. L. Michener, L. J. Askonas, T. D. Penning, Gwen Grabowski Krivi, S. W. Djuric, E. Y. Pyla, Richard A. Haack, Stella S. Yu
Publikováno v:
ChemInform. 27
Autor:
Barnett S. Pitzele, Stella S. Yu, R. G. Bianchi, M. Grebner, B. Rubin, Alan E. Moormann, D. Albin, Peter H. Jones, Gary W. Gullikson, E. L. Sanguinetti
Publikováno v:
Journal of Medicinal Chemistry. 33:614-626
Lofexidine, an alpha 2-agonist, has central hypotensive activity and peripheral intestinal antisecretory activity. Analogues were synthesized with increased polarity in an attempt to prevent penetration of the blood-brain barrier. The compounds were
Autor:
Stella S. Yu, V. J. Kalish, Thomas D. Penning, Bruce W. Rowell, Stevan W. Djuric, Richard A. Haack, Julie M. Miyashiro
Publikováno v:
Synthetic Communications. 20:307-312
Lithium borohydride in the presence of one equivalent of water has been found to be an efficient agent for the reduction of sterically hindered acyloxazolidinones to the corresponding primary alcohol.
Autor:
Kristen E. Shannon, Barbara B. Chen, James W. Malecha, Stephen H Docter, G. Allen Nickols, Thomas D. Penning, Marisa M. Westlin, Glen J. Gesicki, Chi-Dean Liang, Helen Y. Chen, David J. Edwards, Melanie L. Hanneke, Bipin N. Desai, Stella S. Yu, Sandra K. Freeman, Mark A. Russell, V. Wayne Engleman
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(6)
We describe a series of conformationally-restricted cinnamic acid peptidomimetics as well as several cinnamic acid isosteres, including 3-phenylpropionic acids, 2-amino-3-phenylpropionic acids, phenoxyacetic acids and 2-phenylcyclopropylcarboxylic ac
Autor:
Karen Seibert, AndersonGD, John J. Talley, Susan A. Gregory, Matthew J. Graneto, Yan Y. Zhang, James W. Malecha, Len F. Lee, Stella S. Yu, Stephen H. Docter, Bertenshaw, P. C. Isakson, P. W. Collins, E. G. Burton, J. N. Cogburn, Jeffery S. Carter, A. W. Veenhuizen, Carol M. Koboldt, T. D. Penning, Julie M. Miyashiro, D. J. Rogier, W E Perkins, Roland S. Rogers
Publikováno v:
Journal of medicinal chemistry. 40(9)
A series of sulfonamide-containing 1,5-diarylpyrazole derivatives were prepared and evaluated for their ability to block cyclooxygenase-2 (COX-2) in vitro and in vivo. Extensive structure-activity relationship (SAR) work was carried out within this s
Autor:
D. J. Fretland, J. P. McKearn, M. Bremer, Stephen H. Docter, S. K. Paulson, S. W. Djuric, D. L. Widomski, Stella S. Yu, T. D. Penning, C. P. Anglin, Peter C. Isakson
Publikováno v:
Inflammation. 19(2)
Leukotriene B4 (LTB4) and 12(R)-hydroxyeicosatetraenoic acid [12(R)-HETE] are proinflammatory products of arachidonic acid metabolism that have been implicated as mediators in a number of inflammatory diseases. When injected intradermally into the gu
Publikováno v:
Inflammation. 17(3)
Leukotriene B4 (LTB4) is a proinflammatory product of arachidonic acid metabolism that has been implicated as a mediator in a number of inflammatory diseases. When injected intradermally into the guinea pig, LTB4 elicits a dose-dependent migration (c