Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Stella Peña"'
Autor:
Francisco-J. Gamo, Diver Sellanes, Laura M. Sanz, Anna Caroline Campos Aguiar, Elizabeth A. Winzeler, Catherine Fagundez, Stella Peña, Vanessa Yardley, Juliana Oliveira de Souza, Rafael Victorio Carvalho Guido, Gloria Serra, Laura Scarone, Lindsay B. Stewart, Sabine Ottilie
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
[Image: see text] Malaria is a major tropical disease where important needs are to mitigate symptoms and to prevent the establishment of infection. Cyclopeptides containing N-methyl amino acids with in vitro activity against erythrocytic forms as wel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d138e287cb4e19568d42017733795a
https://europepmc.org/articles/PMC6331169/
https://europepmc.org/articles/PMC6331169/
Publikováno v:
Proceedings of the 16th LACCEI International Multi-Conference for Engineering, Education, and Technology: “Innovation in Education and Inclusion”.
1 Escuela Colombiana de Ingenieria Julio Garavito, Colombia, johanna.trujillo@escuelaing.edu.co 2 Universidad Catolica de Colombia, Colombia, fndiaz@ucatolica.edu.co 3 Pontificia Universidad Javeriana, Colombia, ca.villamil@javeriana.edu.co 4 Univers
Autor:
Eduardo Manta, Lindsay B. Stewart, Diver Sellanes, Laura Scarone, Gloria Serra, Marcelo A. Comini, Vanessa Yardley, Andrea Medeiros, Judit Tulla-Puche, Stella Peña, Catherine Fagundez, Fernando Albericio
Publikováno v:
Med. Chem. Commun.. 5:1309-1316
Cyclohexapeptide analogs of natural products were obtained in very good yields by a combination of solid-phase peptide synthesis, for the linear peptide, and solution cyclization. The activities against Plasmodium falciparum K1, Trypanosoma brucei br
Autor:
Laura Scarone, Gloria Serra, Eduardo Manta, Stella Peña, Lindsay B. Stewart, Vanessa Yardley, Simon L. Croft
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4994-4997
The synthesis of a Microcystis aeruginosa predicted metabolite analog of aerucyclamide B was performed. This hexacyclopeptide was obtained from three heterocyclic building blocks by a convergent macrocycle-assembly methodology. The compound exhibited
Publikováno v:
MedChemComm. 3:1443-1448
In the search for candidates of antiparasitic new drugs, macrocycle analogs and key fragments of aerucyclamides were obtained. The activities against Trypanosoma brucei brucei and cytotoxicities on murine macrophages (cell line J774) were evaluated.
Publikováno v:
Chemistry of Heterocyclic Compounds. 47:703-709
A rapid and efficient methodology to prepare 2,4′-bi-1,3-azoles as scaffolds for biologically active marine natural products is described. Hantzsch reaction and oxidative cyclodehydration of β-hydroxy amides or thioamides were used to construct th
Publikováno v:
Future medicinal chemistry. 7(3)
Macrocycles possess desirable properties that make them promising candidates for the discovery of novel drugs. They present structural features to favor bioactive conformations, selectivity to the receptors, cell permeability and metabolic stability.
Publikováno v:
Tetrahedron Letters. 54:2806-2808
The first total synthesis of the antimalarial aerucyclamide B has been achieved in 9% overall yield. Two thiazoles and a dipeptide were used to prepare two open precursors of cyclo-Gly-l-allo-Thr-l-Ile-Thz-d-allo-Ile-Thz. Cyclodehydration with Deoxo-
Autor:
Laura Scarone, Fernando Albericio, Stella Peña, Lindsay B. Stewart, Vanessa Yardley, Andrea Medeiros, Gloria Serra, Marcelo A. Comini
Publikováno v:
Proceedings of the 15th Brazilian Meeting on Organic Synthesis Proceedings.
Publikováno v:
Proceedings of the 14th Brazilian Meeting on Organic Synthesis Proceedings.
Our planed synthesis of 3 began with the construction of three heterocyclic building blocks, 4, 5 and 6, Scheme 1. Scheme1.Synthesis of heterocyclic building blocks 4, 5, 6. Thiazole 4 was obtained by Hantszch reaction from the Boc-Gly thioamide and