Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Stella O. Sieber"'
Autor:
Rddhi Moodliar, Joan Russo, Pete Anziano, Kristina Anderson, Kathleen Moloney, Natalie Vaziri, Peyton Johnson, Ronald V. Maier, Mary Lou Walen, Sara Seo, Lawrence A. Palinkas, Patrick J. Heagerty, Eileen M. Bulger, Stella O. Sieber, Allison Engstrom, Lauren K. Whiteside, Peter Thomas, Douglas F. Zatzick, Hannah Scheuer, Alvaro Martinez
Publikováno v:
Contemp Clin Trials
Annually approximately 2–3 million Americans are so severely injured that they require inpatient hospitalization. The study team, which includes patients, clinical researchers, front-line provider and policy maker stakeholders, has been working tog
Autor:
Stella O. Sieber, Kevin Gerrish, Rick D. Fannin, Pierre R. Bushel, Richard S. Paules, Paul B. Watkins
Publikováno v:
Clinical Pharmacology & Therapeutics. 99:432-441
The diagnosis of drug-induced liver injury is hindered by the limited utility of clinical chemistries. We have shown that hepatotoxicants can produce peripheral blood transcriptome "signatures" (PBTS) in rodents and humans. In this study, 42 adults w
Autor:
Shahid Malik, Jack Newton, Kevin Gerrish, Jason H. Winnike, Ruchir R. Shah, Tong Zhou, Mark W. Russo, Rick D. Fannin, Jeffrey M. Macdonald, Paul B. Watkins, Richard S. Paules, Stella O. Sieber, Joel S. Parker, Thomas M. O’Connell
Publikováno v:
Hepatology. 51:227-236
In the United States drug induced liver injury (DILI) is the most commonly identifiable cause of acute liver failure and is the major reason behind regulatory actions on drugs, including failure to approve for marketing, restrictions on labeled indic
Autor:
William K. Kaufmann, Kristina G. Flores, Richard S. Paules, Paula B. Deming, Alexandra N. Heinloth, Cynthia L. Innes, Stella O. Sieber, Pierre R. Bushel
Publikováno v:
Molecular Cancer Research. 4:197-207
The heritable disorder ataxia telangiectasia (AT) is caused by mutations in the AT-mutated (ATM) gene with manifestations that include predisposition to lymphoproliferative cancers and hypersensitivity to ionizing radiation (IR). We investigated gene
Autor:
Maribel Bruno, Sandra M. Ward, Stella O. Sieber, J. Todd Auman, B. Alex Merrick, Richard S. Paules, Charles J. Tucker, Rick D. Fannin
Publikováno v:
Physiological Genomics. 21:92-104
Microarrays have been used to evaluate the expression of thousands of genes in various tissues. However, few studies have investigated the change in gene expression profiles in one of the most easily accessible tissues, whole blood. We utilized an ac
Autor:
Pierre R. Bushel, Stella O. Sieber, Leping Li, Kristina G. Flores, Rupesh P. Amin, Cynthia L. Innes, Lee Bennett, Rodney E. Shackelford, Alexandra N. Heinloth, Richard S. Paules
Publikováno v:
Radiation Research. 160:273-290
Ataxia telangiectasia (AT) is an autosomal recessive disorder characterized by progressive cerebellar degeneration, immunodeficiencies, telangiectasias, sensitivity to ionizing radiation, and high predisposition for malignancies. The ataxia telangiec
Autor:
Pierre R. Bushel, Lee Bennett, Raymond E. Stoll, J. Carl Barrett, Kerry T. Blanchard, Supriya Jayadev, Cynthia A. Afshari, Olimpia DiSorbo, Stella O. Sieber, Karla Martin, Richard S. Paules, Hisham K. Hamadeh, Raymond W. Tennant
Publikováno v:
Toxicological Sciences. 67:219-231
The application of gene expression profiling technology to examine multiple genes and signaling pathways simultaneously promises a significant advance in understanding toxic mechanisms to ultimately aid in protection of public health. Public and priv
Autor:
Richard S. Paules, Michael L. Cunningham, Raymond E. Stoll, Brian Knight, Stella O. Sieber, Raymond W. Tennant, Supriya Jayadev, Hisham K. Hamadeh, Kerry T. Blanchard, Pierre R. Bushel, Cynthia A. Afshari, Rupesh P. Amin, Astrid C. Haugen
Publikováno v:
Toxicologic Pathology. 30:470-482
Methapyrilene (MP) exposure of animals can result in an array of adverse pathological responses including hepatotoxicity. This study investigates gene expression and histopathological alterations in response to MP treatment in order to 1) utilize com
Publikováno v:
Reproductive toxicology (Elmsford, N.Y.). 28(3)
We hypothesize that TCDD-induced developmental neurotoxicity is modulated through an AhR-dependent interaction with key regulatory neuronal differentiation pathways during telencephalon development. To test this hypothesis we examined global gene exp
Autor:
Michael L. Cunningham, Paul Nettesheim, Rickie D. Fannin, Gary A. Boorman, Alexandra N. Heinloth, Richard D. Irwin, Charles J. Tucker, Raymond W. Tennant, Stella O. Sieber, Leping Li, Gordon Vansant, Pamela E. Blackshear, Richard S. Paules, Gregory S. Travlos, Michael L. Snell
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 80(1)
This study tested the hypothesis that gene expression profiling can reveal indicators of subtle injury to the liver induced by a low dose of a substance that does not cause overt toxicity as defined by conventional criteria of toxicology (e.g., abnor