Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Stella M. Bernardo"'
Autor:
Hallie S. Rane, Summer R. Hayek, Jillian E. Frye, Esteban L. Abeyta, Stella M. Bernardo, Karlett J. Parra, Samuel A. Lee
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Candida albicans occupies diverse ecological niches within the host and must tolerate a wide range of environmental pH. The plasma membrane H+-ATPase Pma1p is the major regulator of cytosolic pH in fungi. Pma1p extrudes protons from the cytosol to ma
Externí odkaz:
https://doaj.org/article/ecb06677c7e44e08a67747cfe50235dc
Publikováno v:
Current Fungal Infection Reports. 11:220-228
In this review, we will assess what is currently known about Candida biofilms, its epidemiology and impact on clinical practice, and the biology underlying biofilm-related antifungal drug resistance. We also review potential antifungal lock therapies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ebf18666f60174f58443382e8873b4b
https://doi.org/10.1007/s12281-017-0302-9
https://doi.org/10.1007/s12281-017-0302-9
Autor:
Jillian E. Frye, Karlett J. Parra, Samuel A. Lee, Summer R. Hayek, Esteban Abeyta, Hallie S. Rane, Stella M. Bernardo
Publikováno v:
Frontiers in Microbiology
Frontiers in Microbiology, Vol 10 (2019)
Frontiers in Microbiology, Vol 10 (2019)
Candida albicans occupies diverse ecological niches within the host and must tolerate a wide range of environmental pH. The plasma membrane H+-ATPase Pma1p is the major regulator of cytosolic pH in fungi. Pma1p extrudes protons from the cytosol to ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a155460bb828141f4574f6ea7a5f761
https://doi.org/10.3389/fmicb.2019.01012
https://doi.org/10.3389/fmicb.2019.01012
Publikováno v:
Current Genetics. 62:343-346
The exocyst is an octameric complex that orchestrates the docking and tethering of vesicles to the plasma membrane during exocytosis and is fundamental for key biological processes including growth and establishment of cell polarity. Although compone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2edc69329325e61237b4c05c8719eed8
https://doi.org/10.1007/s00294-015-0553-3
https://doi.org/10.1007/s00294-015-0553-3
Publikováno v:
Eukaryotic Cell. 14:1228-1239
In prior studies of exocyst-mediated late secretion in Candida albicans , we have determined that Sec6 contributes to cell wall integrity, secretion, and filamentation. A conditional mutant lacking SEC6 expression exhibits markedly reduced lateral hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d0828141c086875f802b294853aed73
https://doi.org/10.1128/ec.00147-15
https://doi.org/10.1128/ec.00147-15
Autor:
Faye D. Schilkey, Hallie S. Rane, Stella M. Bernardo, Thiruvarangan Ramaraj, Johnny Sena, Anitha Sundararajan, Samuel A. Lee, Amy B. Howell
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0201969 (2018)
PLoS ONE
PLoS ONE
Candida albicans is one of the most common causes of hospital-acquired urinary tract infections (UTIs). However, azoles are poorly active against biofilms, echinocandins do not achieve clinically useful urinary concentrations, and amphotericin B exhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bccf995f27032eccc8c4e28e0c3835c
http://europepmc.org/articles/PMC6082538?pdf=render
http://europepmc.org/articles/PMC6082538?pdf=render
Autor:
Maximillian Jahng, Samuel A. Lee, Karlett J. Parra, Stella M. Bernardo, Vibhati Kulkarny, Alba Chavez-Dozal, Hallie S. Rane
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:7501-7509
Candida albicans is a common cause of catheter-related bloodstream infections (CR-BSI), in part due to its strong propensity to form biofilms. Drug repurposing is an approach that might identify agents that are able to overcome antifungal drug resist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5c4f14caafc83e02bf087e4ba68e1bd
https://doi.org/10.1128/aac.03083-14
https://doi.org/10.1128/aac.03083-14
Publikováno v:
FEMS Yeast Research. 14:762-775
To study the role of late secretion in Candida albicans pathogenesis, we created conditional mutant C. albicans strains in which the t-SNARE-encoding genes SSO2 or SEC9 were placed under the control of a tetracycline-regulated promoter. In repressing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576a86e7b32a181d1e021b918248371b
https://doi.org/10.1111/1567-1364.12165
https://doi.org/10.1111/1567-1364.12165
Autor:
Samuel A. Lee, Alba Chavez-Dozal, Maximillian Jahng, Vibhati Kulkarny, Hallie S. Rane, Stella M. Bernardo, Kingsley A. Asare
Publikováno v:
International Journal of Antimicrobial Agents. 43:86-91
In a recent high-throughput screen against specific Candida albicans drug targets, several compounds that exhibited non-specific antifungal activity were identified, including the non-steroidal anti-inflammatory drug flufenamic acid (FFA). This study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96486000be162cdd91702cdb2fcdcd69
https://doi.org/10.1016/j.ijantimicag.2013.08.018
https://doi.org/10.1016/j.ijantimicag.2013.08.018
Autor:
Samuel A. Lee, Summer M. Raines, Stella M. Bernardo, Karlett J. Parra, Hallie S. Rane, Jessica L. Binder
Publikováno v:
Journal of Biological Chemistry. 288:6190-6201
Vacuolar proton-translocating ATPase (V-ATPase) is a central regulator of cellular pH homeostasis, and inactivation of all V-ATPase function has been shown to prevent infectivity in Candida albicans. V-ATPase subunit a of the Vo domain (Voa) is prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee650668e0cb76d859784f37c77678f5
https://doi.org/10.1074/jbc.m112.426197
https://doi.org/10.1074/jbc.m112.426197