Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Stella Amanda"'
Autor:
Stella Amanda, Tze King Tan, Jolynn Zu Lin Ong, Madelaine Skolastika Theardy, Regina Wan Ju Wong, Xiao Zi Huang, Muhammad Zulfaqar Ali, Yan Li, Zhiyuan Gong, Hiroshi Inagaki, Ee Yong Foo, Brendan Pang, Soo Yong Tan, Shinsuke Iida, Takaomi Sanda
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
IRF4 is a regulator of immune function, and is overexpressed in lymphoid neoplasms. Here, the authors utilise single cell RNA-seq to show the abundance of double-negative T cells in IRF4 driven zebrafish tumour models, and identify sensitivity of the
Externí odkaz:
https://doaj.org/article/ff3debb04d284c5488577eed6625143c
Autor:
Chujing Zhang, Stella Amanda, Cheng Wang, Tze King Tan, Muhammad Zulfaqar Ali, Wei Zhong Leong, Ley Moy Ng, Shojiro Kitajima, Zhenhua Li, Allen Eng Juh Yeoh, Shi Hao Tan, Takaomi Sanda
Publikováno v:
Haematologica, Vol 106, Iss 6 (2020)
Aldehyde dehydrogenases (ALDHs) are overexpressed in various types of cancers. One of the ALDH family genes, ALDH1A2, is aberrantly expressed in more than 50% of T-cell acute lymphoblastic leukemia (T-ALL) cases. However, its molecular function and r
Externí odkaz:
https://doaj.org/article/877f839302c44916952c9e4beacd7d30
Autor:
Stella, Amanda1 (AUTHOR) as247226@pcom.edu, Tuluca, Alexandra1 (AUTHOR), Arce, Anastasia1 (AUTHOR), Samuels, Louis1 (AUTHOR)
Publikováno v:
Journal of Cardiothoracic Surgery. 10/1/2022, Vol. 17 Issue 1, p1-4. 4p.
Publikováno v:
Experimental Hematology. 114:9-17
Dysregulation of transcription factor genes represents a unique molecular etiology of hematological malignancies. A number of transcription factors that play a role in hematopoietic cell development, lymphocyte activation, or their maintenance have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebb39c7d7b9c257fd9f6f9d3e1c2dba0
https://doi.org/10.1016/j.exphem.2022.07.300
https://doi.org/10.1016/j.exphem.2022.07.300
Autor:
Ley Moy Ng, Takaomi Sanda, Chujing Zhang, Wei Zhong Leong, Shi Hao Tan, Tze King Tan, Cheng Wang, Allen Eng Juh Yeoh, Stella Amanda, Zhenhua Li, Muhammad Zulfaqar Ali, Shojiro Kitajima
Publikováno v:
Haematologica
Aldehyde dehydrogenases (ALDH) are overexpressed in various types of cancers. One of the ALDH family genes, ALDH1A2, is aberrantly expressed in more than 50% of cases of T-cell acute lymphoblastic leukemia (T-ALL). However, its molecular function and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11fea53b53ac629ec00c253c970e6448
https://doi.org/10.3324/haematol.2019.245639
https://doi.org/10.3324/haematol.2019.245639
Autor:
Stella Amanda, Tze King Tan, Jolynn Zu Lin Ong, Madelaine Skolastika Theardy, Regina Wan Ju Wong, Xiao Zi Huang, Muhammad Zulfaqar Ali, Li Yan, Zhiyuan Gong, Hiroshi Inagaki, Ee Yong Foo, Brendan Pang, Soo Yong Tan, Shinsuke Iida, Takaomi Sanda
Publikováno v:
Cancer Research. 82:LB018-LB018
IRF4 is a master regulator of immunity and is also frequently overexpressed in mature lymphoid neoplasms. Here, we demonstrate the stage-specific oncogenicity of IRF4 in vivo, its potential effects on T-cell development and clonal evolution using a z
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::881b3828dce989a3c4496621a9a5b055
https://doi.org/10.1158/1538-7445.am2022-lb018
https://doi.org/10.1158/1538-7445.am2022-lb018
Autor:
Wei Zhong Leong, Takaomi Sanda, Tze King Tan, Shi Hao Tan, Ryuzo Ueda, Regina Wan Ju Wong, Yurina Hibi, Takashi Okamoto, Shinsuke Iida, Kaori Asamitsu, Takashi Ishida, Phuong Cao Thi Ngoc, Stella Amanda
Publikováno v:
Blood. 135(12)
Adult T-cell leukemia/lymphoma (ATL) is a highly aggressive hematological malignancy derived from mature CD4+ T-lymphocytes. Here, we demonstrate the transcriptional regulatory network driven by 2 oncogenic transcription factors, IRF4 and NF-κB, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582dbd89fc3c2973fd28930d2a56f6ba
https://pubmed.ncbi.nlm.nih.gov/32191800
https://pubmed.ncbi.nlm.nih.gov/32191800
Autor:
Cheng Wang, Shi Hao Tan, Chujing Zhang, Stella Amanda, Allen Eng Juh Yeoh, Zulfaqar Ali Muhammad, Shojiro Kitajima, Wei Zhong Leong, Ley Moy Ng, Zhenhua Li, Takaomi Sanda, Tze King Tan
Publikováno v:
Cancer Research. 80:LB-301
Aldehyde dehydrogenases (ALDHs) have been implicated as a stem cell marker both in normal and malignant cells. Elevated ALDH activity is associated with the stemness capability as well as the drug resistance in various cancers. As a notable example,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9d6e7e8f30b0559580f4f04ff43e192
https://doi.org/10.1158/1538-7445.am2020-lb-301
https://doi.org/10.1158/1538-7445.am2020-lb-301
Autor:
Shi Hao Tan, Takaomi Sanda, Wei-Siang Liau, Lee N. Lawton, Zhiyuan Gong, Alice Wei Yee Yam, Stella Amanda, Phuong Cao Thi Ngoc, Wei Zhong Leong, Daniel G. Tenen
The oncogenic transcription factor TAL1/SCL induces an aberrant transcriptional program in T-cell acute lymphoblastic leukemia (T-ALL) cells. However, the critical factors that are directly activated by TAL1 and contribute to T-ALL pathogenesis are l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056fcbf9c821ca96a034b0132949f387
https://europepmc.org/articles/PMC5795782/
https://europepmc.org/articles/PMC5795782/
Autor:
Regina Wan Ju Wong, Yan Li, Zhi Yuan Gong, Tze King Tan, Muhammad Zulfaqar Ali, Shinsuke Iida, Takaomi Sanda, Stella Amanda
Publikováno v:
Blood. 134:1242-1242
Introduction The transcription factor IRF4, a member of Interferon Regulatory Factor (IRF) family, is a critical regulator for the production of functional B and T lymphocytes. The dysregulation of IRF4 expression has been frequently implicated in va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82baef6729806db7770a093701a42d4b
https://doi.org/10.1182/blood-2019-129714
https://doi.org/10.1182/blood-2019-129714