Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Stella Vincent"'
Autor:
Derun Li, David L. Sloman, Abdelghani Achab, Hua Zhou, Meredeth A. McGowan, Catherine White, Craig Gibeau, Hongjun Zhang, Qinglin Pu, Indu Bharathan, Brett Hopkins, Kun Liu, Heidi Ferguson, Xavier Fradera, Charles A. Lesburg, Theodore A. Martinot, Ji Qi, Zhiguo J. Song, Jingjun Yin, Huangguang Zhang, Licheng Song, Baoqiang Wan, Suzanne DAddio, Nicolas Solban, J. Richard Miller, Beata Zamlynny, Alan Bass, Elizabeth Freeland, Bridget Ykoruk, Catherine Hilliard, Jude Ferraro, Jin Zhai, Ian Knemeyer, Karin M. Otte, Stella Vincent, Nunzio Sciammetta, Alexander Pasternak, David Jonathan Bennett, Yongxin Han
Publikováno v:
Journal of medicinal chemistry. 65(8)
3,3-Disubstituted oxetanes have been utilized as bioisosteres for gem-dimethyl and cyclobutane functionalities. We report the discovery of a novel class of oxetane indole-amine 2,3-dioxygenase (IDO1) inhibitors suitable for Q3W (once every 3 weeks) o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65de888aa90fb7088ca022d5b5ddf12
https://pubmed.ncbi.nlm.nih.gov/35239336
https://pubmed.ncbi.nlm.nih.gov/35239336
Autor:
Linus S, Lin, Thomas, Lanza, James P, Jewell, Ping, Liu, Carrie, Jones, Gerard R, Kieczykowski, Kelly, Treonze, Qian, Si, Salony, Manior, Gloria, Koo, Xinchun, Tong, Junying, Wang, Anne, Schuelke, James, Pivnichny, Regina, Wang, Conrad, Raab, Stella, Vincent, Philip, Davies, Malcolm, Maccoss, Richard A, Mumford, William K, Hagmann
Publikováno v:
Journal of medicinal chemistry. 52(11)
Extremely potent very late antigen-4 (VLA-4) antagonists with picomolar, whole blood activity and slow dissociation rates were discovered by incorporating an amino substituent on the proline fragment of the initial lead structure. This level of poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e9a6bbef5a020db297b6f1e1be61f223
https://pubmed.ncbi.nlm.nih.gov/19441819
https://pubmed.ncbi.nlm.nih.gov/19441819
Autor:
Zhongzhou, Shen, Ray, Bakhtiar, Masakatsu, Komuro, Katsuya, Awano, Fukutaro, Taga, Adria, Colletti, Don, Hora, William, Feeney, Susan, Iliff, Ronald B, Franklin, Stella, Vincent
Publikováno v:
Rapid communications in mass spectrometry : RCM. 19(9)
MK-0767, (+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl)phenyl]methyl]benzamide, is a thiazolidinedione-containing dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist that has been studied as a pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::95d350b3dcb980743f79d9e6d56891fd
https://pubmed.ncbi.nlm.nih.gov/15799073
https://pubmed.ncbi.nlm.nih.gov/15799073
Autor:
Linda L, Chang, Quang, Truong, Richard A, Mumford, Linda A, Egger, Usha, Kidambi, Kathryn, Lyons, Ermengilda, McCauley, Gail, Van Riper, Stella, Vincent, John A, Schmidt, Malcolm, MacCoss, William K, Hagmann
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(2)
The alpha(4)beta(1) and alpha(4)beta(7) integrins are implicated in several inflammatory disease states. Systematic SAR studies of an alpha(4)beta(1)-specific arylsulfonyl-Pro-Tyr lead led to the identification of a new alpha(4)beta(7) binding site,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a8b293ec36f56d6f38c54267f241828e
https://pubmed.ncbi.nlm.nih.gov/11755344
https://pubmed.ncbi.nlm.nih.gov/11755344
Autor:
Gloria C. Koo, Joseph T. Blake, Kashmira Shah, Mary Jo Staruch, Francis Dumont, Denise Wunderler, Manuel Sanchez, Owen B. McManus, Anna Sirotina-Meisher, Paul Fischer, Robert C. Boltz, Michael A. Goetz, Robert Baker, Jianming Bao, Frank Kayser, Kathleen M. Rupprecht, William H. Parsons, Xin-Chun Tong, Ida E. Ita, Jim Pivnichny, Stella Vincent, Paul Cunningham, Don Hora, William Feeney, Gregory Kaczorowski, Martin S. Springer
Publikováno v:
Cellular immunology. 197(2)
The voltage-gated potassium channel, Kv1.3, is specifically expressed on human lymphocytes, where it controls membrane potential and calcium influx. Blockade of Kv1.3 channels by margatoxin was previously shown to prevent T cell activation and attenu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcda40f55f29f5859d20630c9ae7b308
https://pubmed.ncbi.nlm.nih.gov/10607427
https://pubmed.ncbi.nlm.nih.gov/10607427
Autor:
Linus S. Lin, Thomas Lanza, James P. Jewell, Ping Liu, Carrie Jones, Gerard R. Kieczykowski, Kelly Treonze, Qian Si, Salony Manior, Gloria Koo, Xinchun Tong, Junying Wang, Anne Schuelke, James Pivnichny, Regina Wang, Conrad Raab, Stella Vincent, Philip Davies, Malcolm MacCoss, Richard A. Mumford
Publikováno v:
Journal of Medicinal Chemistry; Jun2009, Vol. 52 Issue 11, p3449-3452, 4p