Výsledky vyhledávání - "Stella, Markosyan"

Characterization and comparison of rat monosodium iodoacetate and medial meniscal tear models of osteoarthritic pain

Autor: Arthur L. Nikkel, Stella Markosyan, Michael F. Jarvis, Katharine L. Chu, Jill-Desiree Brederson, Robert S. Bitner, Rebecca M. Edelmayer, Steve McGaraughty, Jun Xu

Publikováno v: Journal of Orthopaedic Research®. 36:2109-2117

Osteoarthritis (OA) is a degenerative form of arthritis that can result in loss of joint function and chronic pain. The pathological pain state that develops with OA disease involves plastic changes in the peripheral and central nervous systems, howe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5aa2f03d418732f3471116d24283369f
https://doi.org/10.1002/jor.23869

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Characterization and comparison of rat monosodium iodoacetate and medial meniscal tear models of osteoarthritic pain

Autor: Jill-Desiree, Brederson, Katharine L, Chu, Jun, Xu, Arthur L, Nikkel, Stella, Markosyan, Michael F, Jarvis, Rebecca, Edelmayer, Robert S, Bitner, Steve, McGaraughty

Publikováno v: Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e55f166f60cea88af7c2f2891f67382b
https://pubmed.ncbi.nlm.nih.gov/29430715

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In Vivo Pharmacological Characterization of a Novel Selective α7 Neuronal Nicotinic Acetylcholine Receptor Agonist ABT-107: Preclinical Considerations in Alzheimer's Disease

Autor: Stella Markosyan, Kennan C. Marsh, R. Scott Bitner, Rich Radek, Karla Drescher, Jerry J. Buccafusco, Arthur L. Nikkel, William H. Bunnelle, Murali Gopalakrishnan, David J. Anderson, Michael W. Decker, Kaitlin E. Browman, Kathy L. Kohlhaas

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 334:875-886

We previously reported that alpha7 nicotinic acetylcholine receptor (nAChR) agonism produces efficacy in preclinical cognition models correlating with activation of cognitive and neuroprotective signaling pathways associated with Alzheimer's disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e2cd617b71f518e00f6178f2e34ea1
https://doi.org/10.1124/jpet.110.167213

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Mice expressing the Swedish APP mutation on a 129 genetic background demonstrate consistent behavioral deficits and pathological markers of Alzheimer's disease

Autor: Teresa Ellis, Peter Curzon, Stella Markosyan, Lynne E. Rueter, Kaitlin E. Browman, Elizabeth A. Cronin, Robert S. Bitner, Jeffrey F. Waring, Michael W. Decker, Nathan R. Rustay

Publikováno v: Brain Research. 1311:136-147

Mutant Tg2576 mice which possess the human "Swedish" APP mutation have been shown to demonstrate both Abeta plaque pathology and memory deficits in behavioral tasks. These mice are routinely maintained on a mixed C57BL/6xSJL genetic background which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b53d9f0ca663260d245fb335e8ec17d
https://doi.org/10.1016/j.brainres.2009.11.040

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The novel calpain inhibitor A-705253 prevents stress-induced tau hyperphosphorylation in vitro and in vivo

Autor: Arthur L. Nikkel, Brenda Martino, Stella Markosyan, Robert S. Bitner, Rodrigo Medeiros, Achim Moeller, Jill-Desiree Brederson

Publikováno v: Neuropharmacology. 63(4)

Calcium-mediated pathologic activation of the cysteine protease calpain has been linked to neurodegenerative disorders such as Alzheimer's disease (AD) through the cleavage of proteolytic substrates that negatively affect neuronal function. Hyperphos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8581b10f0a526a4434b8663d00af201d
https://pubmed.ncbi.nlm.nih.gov/22613839

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Acute inhibition of 11beta-hydroxysteroid dehydrogenase type-1 improves memory in rodent models of cognition

Autor: Marina I. Strakhova, Peer B. Jacobson, Elizabeth A. Cronin, Wilfried Hornberger, Stella Markosyan, Michael E. Brune, Victoria A. Roderwald, Kaitlin E. Browman, Rohde Jeffrey J, Eric G. Mohler, Karla Drescher, Lynne E. Rueter, R. Scott Bitner

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(14)

Mounting evidence suggests excessive glucocorticoid activity may contribute to Alzheimer's disease (AD) and age-associated memory impairment. 11β-hydroxysteroid dehydrogenase type-1 (HSD1) regulates conversion of glucocorticoids from inactive to act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14cf3e33536455ff58d6a00bca96e5b7
https://pubmed.ncbi.nlm.nih.gov/21471376

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In-vivo histamine H3 receptor antagonism activates cellular signaling suggestive of symptomatic and disease modifying efficacy in Alzheimer's disease

Autor: Stella Markosyan, Jorge D. Brioni, R. Scott Bitner, Arthur L. Nikkel

Publikováno v: Neuropharmacology. 60(2-3)

Histamine H(3) receptor antagonists enhance cognition in preclinical models and have been proposed as novel therapeutics for cognitive disorders, in particular Alzheimer's disease (AD). Increased neurotransmitter (e.g. acetylcholine and histamine) re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f20ba5df8ffcacdba64fe2d4b6b4873
https://pubmed.ncbi.nlm.nih.gov/21044639

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