Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Stelios T. Tzannis"'
Autor:
Katherine H. Schreiber, Sebastian I. Arriola Apelo, Deyang Yu, Jacqueline A. Brinkman, Michael C. Velarde, Faizan A. Syed, Chen-Yu Liao, Emma L. Baar, Kathryn A. Carbajal, Dawn S. Sherman, Denise Ortiz, Regina Brunauer, Shany E. Yang, Stelios T. Tzannis, Brian K. Kennedy, Dudley W. Lamming
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Rapamycin extends lifespan in model organisms by targeting mTORC1, but exerts off-target side effects via inhibition of mTORC2. Here, the authors report the identification of a selective mTORC1 inhibitor, and show that it inhibits mTORC1 activity bot
Externí odkaz:
https://doaj.org/article/62fe1b728b0148059e306c8857df6c69
Autor:
Jennifer M. Lobo, Andrew Reginald Clark, Helena Schiavone, Stelios T. Tzannis, Srinivas Palakodaty, Peter York
Publikováno v:
Journal of Pharmaceutical Sciences. 94:2276-2288
The objective of this study was to develop SEDS-engineered budesonide particles suitable for dry powder inhalation delivery and to evaluate their aerosol performance across a range of passive dry powder inhalers (DPI). SEDS budesonide powders were ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ad61bf1d570d0380cc7073e587d6ac
https://doi.org/10.1002/jps.20305
https://doi.org/10.1002/jps.20305
Publikováno v:
Journal of Pharmaceutical Sciences. 88:360-370
The preparation of stable solid protein formulations presents significant challenges. Ultimately, the interactions between incorporated excipients and the pharmaceutical protein determine the formulation stability. In this study, moisture was utilize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64df1fe37e2d56ceb686677dc071ea86
https://doi.org/10.1021/js9800127
https://doi.org/10.1021/js9800127
Publikováno v:
Journal of Pharmaceutical Sciences. 88:351-359
The preparation and processing of protein pharmaceuticals into powders may impose significant stresses that could perturb and ultimately denature them. In many cases their stabilization through added excipients is necessary to yield native and active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec8a2bea58a7932f4144acc70ea78da
https://doi.org/10.1021/js980011e
https://doi.org/10.1021/js980011e
Publikováno v:
Journal of Colloid and Interface Science. 189:216-228
The interactions between therapeutic proteins and delivery device surfaces may have a significant impact on the efficacy of a recombinant protein-based biological therapy program. Protein–surface interactions may induce conformational changes and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f373e918178aea660126331cf6fb1a0
https://doi.org/10.1006/jcis.1997.4841
https://doi.org/10.1006/jcis.1997.4841
Publikováno v:
Proceedings of the National Academy of Sciences. 93:5460-5465
The physical stability of pharmaceutical proteins in delivery environments is a critical determinant of biological potency and treatment efficacy, and yet it is often taken for granted. We studied both the bioactivity and physical stability of interl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b1e8815e842d142e4b651876f0856dc
https://doi.org/10.1073/pnas.93.11.5460
https://doi.org/10.1073/pnas.93.11.5460
High concentration formulation feasibility of human immunoglubulin G for subcutaneous administration
Publikováno v:
Journal of pharmaceutical sciences. 96(6)
The delivery of monoclonal antibodies (mAbs) as subcutaneous (sc) injections hinges on the high dose requirement of these usually low potency molecules. This necessitates their formulation as high concentration solutions or suspensions, which present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341c5ee9f3284d37e3274eb746dac3cd
https://pubmed.ncbi.nlm.nih.gov/17387698
https://pubmed.ncbi.nlm.nih.gov/17387698
Publikováno v:
International journal of pharmaceutics. 281(1-2)
The objective of this study was to assess the performance of SCF-engineered budesonide and albuterol sulfate powder blends in passive dry powder inhalers (DPI) relative to micronized drug blends. A number of lactose grades for inhalation were screene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c22ecf532a9efe2e1657de473e8cb789
https://pubmed.ncbi.nlm.nih.gov/15288343
https://pubmed.ncbi.nlm.nih.gov/15288343
Publikováno v:
Analytical biochemistry. 285(1)
We present an improved technique for estimating protein secondary structure content from amide I and amide III band infrared spectra. This technique combines the superposition of reference spectra of pure secondary structure elements with simultaneou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ff44ed06ceb9a889f074ea411b6f75
https://pubmed.ncbi.nlm.nih.gov/10998261
https://pubmed.ncbi.nlm.nih.gov/10998261
Publikováno v:
MRS Proceedings. 331
The interactions between a therapeutic protein and the surfaces of a delivery device may play a pivotal role in the efficacy of a recombinant protein-based biologic therapy program. Protein adsorption may induce conformational changes and aggregation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de67064dea5891882aa78815cb2da6e9
https://doi.org/10.1557/proc-331-227
https://doi.org/10.1557/proc-331-227