Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Stelios T Andreadis"'
Autor:
Kihoon Nam, Christina L Maruyama, Ching-Shuen Wang, Bryan G Trump, Pedro Lei, Stelios T Andreadis, Olga J Baker
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187069 (2017)
Hyposalivation reduces the patient quality of life, as saliva is important for maintaining oral health. Current treatments for hyposalivation are limited to medications such as the muscarinic receptor agonists, pilocarpine and cevimeline. However, th
Externí odkaz:
https://doaj.org/article/2043e9fb5fa6498e9bc39dd5a5ddce6a
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141365 (2015)
Stem cell differentiation involves multiple cascades of transcriptional regulation that govern the cell fate. To study the real-time dynamics of this complex process, quantitative and high throughput live cell assays are required. Herein, we develope
Externí odkaz:
https://doaj.org/article/232458ff2daa4fb0b07877348edbf8d4
Autor:
Samantha E. Cassel, Breanna M. Huntington, Wilfred Chen, Pedro Lei, Stelios T. Andreadis, April M. Kloxin
Publikováno v:
APL Bioengineering, Vol 8, Iss 2, Pp 026127-026127-17 (2024)
Activation of fibroblasts is pivotal for wound healing; however, persistent activation leads to maladaptive processes and is a hallmark of fibrosis, where disease mechanisms are only partially understood. Human in vitro model systems complement in vi
Externí odkaz:
https://doaj.org/article/cb5866edd5e14cf7bca82c5be176521e
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79265 (2013)
Although cellular signaling pathways that affect lentivirus infection have been investigated, the role of cell-cell interactions in lentiviral gene delivery remains elusive. In the course of our studies we observed that lentiviral gene transfer was a
Externí odkaz:
https://doaj.org/article/9cf214d06b034112a1a9538a6fe3b23f
Autor:
Yayu Liu, Pedro Lei, Ronel Z. Samuel, Anagha M. Kashyap, Theodore Groth, Wiam Bshara, Sriram Neelamegham, Stelios T. Andreadis
Publikováno v:
Molecular Oncology, Vol 17, Iss 10, Pp 2056-2073 (2023)
During epithelial–mesenchymal transition (EMT) in cancer progression, tumor cells switch cadherin profile from E‐cadherin to cadherin‐11 (CDH11), which is accompanied by increased invasiveness and metastatic activity. However, the mechanism thr
Externí odkaz:
https://doaj.org/article/61a8c0a37da6437793ec0e2602e16bc1
Autor:
Debanik Choudhury, Na Rong, Hamsa Vardini Senthil Kumar, Sydney Swedick, Ronel Z. Samuel, Pihu Mehrotra, John Toftegaard, Nika Rajabian, Ramkumar Thiyagarajan, Ashis K. Podder, Yulun Wu, Shahryar Shahini, Kenneth L. Seldeen, Bruce Troen, Pedro Lei, Stelios T. Andreadis
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113738- (2024)
Summary: Mitochondrial dysfunction is a hallmark of cellular senescence, with the loss of mitochondrial function identified as a potential causal factor contributing to senescence-associated decline in cellular functions. Our recent findings revealed
Externí odkaz:
https://doaj.org/article/7e0989fdc4cd4210b9b77af2703db105
Autor:
Nika Rajabian, Izuagie Ikhapoh, Shahryar Shahini, Debanik Choudhury, Ramkumar Thiyagarajan, Aref Shahini, Joseph Kulczyk, Kendall Breed, Shilpashree Saha, Mohamed Alaa Mohamed, Susan B. Udin, Aimee Stablewski, Kenneth Seldeen, Bruce R. Troen, Kirkwood Personius, Stelios T. Andreadis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Aged myoblasts suffer from impaired glycolysis and insulin resistance, but increase methionine catabolism, possibly to meet energetic demands. Here, authors show that inhibiting methionine metabolism via NANOG reprogramming or MAT2A inhibition restor
Externí odkaz:
https://doaj.org/article/20d14dcf72624910a7c1176a420cedc0
Downregulation of YAP Activity Restricts P53 Hyperactivation to Promote Cell Survival in Confinement
Autor:
Farnaz Hemmati, Ayuba Akinpelu, Jiyeon Song, Farshad Amiri, Anya McDaniel, Collins McMurray, Alexandros Afthinos, Stelios T. Andreadis, Andrew V. Aitken, Vinicia C. Biancardi, Sharon Gerecht, Panagiotis Mistriotis
Publikováno v:
Advanced Science, Vol 10, Iss 23, Pp n/a-n/a (2023)
Abstract Cell migration through confining three dimensional (3D) topographies can lead to loss of nuclear envelope integrity, DNA damage, and genomic instability. Despite these detrimental phenomena, cells transiently exposed to confinement do not us
Externí odkaz:
https://doaj.org/article/0ffb15d0004f4eed9ae794c90274936d
Autor:
Mohamed Alaa Mohamed, Lingyue Yan, Aref Shahini, Nika Rajabian, Amin Jafari, Stelios T. Andreadis, Yun Wu, Chong Cheng
Publikováno v:
ACS Applied Bio Materials. 5:4779-4792
The worldwide steady increase in the number of cancer patients motivates the development of innovative drug delivery systems for combination therapy as an effective clinical modality for cancer treatment. Here, we explored a design concept based on p
Autor:
Nika Rajabian, Debanik Choudhury, Izuagie Ikhapoh, Shilpashree Saha, Aishwarya S. Kalyankar, Pihu Mehrotra, Aref Shahini, Kendall Breed, Stelios T. Andreadis
Publikováno v:
Aging Cell. 22