Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Stelian S, Maier"'
Autor:
Denisse-Iulia Bostiog, Natalia Simionescu, Adina Coroaba, Ioana C. Marinas, Mariana C. Chifiriuc, Gratiela Gradisteanu Pircalabioru, Stelian S. Maier, Mariana Pinteala
Publikováno v:
Drug Delivery, Vol 31, Iss 1 (2024)
Methotrexate (MTX) is a folic acid antagonist routinely used in cancer treatment, characterized by poor water solubility and low skin permeability. These issues could be mitigated by using drug delivery systems, such as functionalized gold nanopartic
Externí odkaz:
https://doaj.org/article/b7855c1900d84980854cbc373f538aa5
Autor:
Andrea Angeli, Mariana Pinteala, Stelian S. Maier, Sonia Del Prete, Clemente Capasso, Bogdan C. Simionescu, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 244-249 (2019)
A series of benzenesulfonamides incorporating selenazoles with diverse substitution patterns were investigated as inhibitors of six bacterial carbonic anhydrases (CAs, EC 4.2.1.1) from bacterial pathogens, such as Helicobacter pylori (hpCAα was the
Externí odkaz:
https://doaj.org/article/c2724a019533404f899abec29e79991d
Autor:
Andrea Angeli, Mariana Pinteala, Stelian S. Maier, Sonia Del Prete, Clemente Capasso, Bogdan C. Simionescu, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 644-650 (2019)
Famotidine, an antiulcer drug belonging to the H2 antagonists class of pharmacological agents, was recently shown to potently inhibit human (h) and bacterial carbonic anhydrases (CAs, EC 4.2.1.1). We investigated the inhibitory effects of famotidine
Externí odkaz:
https://doaj.org/article/13ab96d95ffd44b996c6e824a9234e1d
Autor:
Andrea Angeli, Sonia Del Prete, Mariana Pinteala, Stelian S. Maier, William A. Donald, Bogdan C. Simionescu, Clemente Capasso, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1178-1185 (2019)
The activation of the β-class carbonic anhydrases (CAs, EC 4.2.1.1) from the bacteria Brucella suis and Francisella tularensis with amine and amino acids was investigated. BsuCA 1 was sensitive to activation with amino acids and amines, whereas FtuC
Externí odkaz:
https://doaj.org/article/92b028b5e8624bb4b1b21a5f57a08e7d
Autor:
Anca-Roxana Petrovici, Mihaela Silion, Natalia Simionescu, Rami Kallala, Mariana Pinteala, Stelian S. Maier
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 11, p 5944 (2022)
Zoledronic acid (ZA) is used in the treatment of various bone pathologies, but it forms complexes with calcium ions present in body fluids, decreasing ZA bioavailability. Thereby, the study first describes the identification of ZA-calcium complexes t
Externí odkaz:
https://doaj.org/article/75f836bbc1ee47fcbf9a43a2fb1e3f38
Autor:
Adina Coroaba, Anca E. Chiriac, Liviu Sacarescu, Tudor Pinteala, Bogdan Minea, Sorin-Alexandru Ibanescu, Mihaela Pertea, Aurelian Moraru, Irina Esanu, Stelian S. Maier, Anca Chiriac, Mariana Pinteala
Publikováno v:
PeerJ, Vol 8, p e8376 (2020)
Background Alopecia areata (AA) is a T-cell-mediated autoimmune disease and affects up to 2% of the population. There is a need for a more profound and rigorous understanding of the structure and composition of human hair affected by AA in order to m
Externí odkaz:
https://doaj.org/article/efa7a6e8b3b64a1f92315d016b16bae3
Autor:
Andrea Angeli, Marta Ferraroni, Mariana Pinteala, Stelian S. Maier, Bogdan C. Simionescu, Fabrizio Carta, Sonia Del Prete, Clemente Capasso, Claudiu T. Supuran
Publikováno v:
Molecules, Vol 25, Iss 10, p 2269 (2020)
Carbonic anhydrase (CA) is a zinc enzyme that catalyzes the reversible conversion of carbon dioxide to bicarbonate and proton. Currently, CA inhibitors are widely used as antiglaucoma, anticancer, and anti-obesity drugs and for the treatment of neuro
Externí odkaz:
https://doaj.org/article/aabff169ff27464ab1a1317a06a74ed3
Autor:
Andrea Angeli, Mariana Pinteala, Stelian S. Maier, Bogdan C. Simionescu, Akram A. Da’dara, Patrick J. Skelly, Claudiu T. Supuran
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1842 (2020)
Schistosomiasis is a debilitating infection provoked by parasitic flatworms called schistosomes. The species Schistosoma mansoni is endemic in Africa, where it causes intestinal schistosomiasis. Recently, an α-carbonic anhydrase (CA, EC 4.2.1.1) was
Externí odkaz:
https://doaj.org/article/e1ba47ed44974de0947fa405109a0683
Autor:
Andrea Angeli, Mariana Pinteala, Stelian S. Maier, Bogdan C. Simionescu, Andrea Milaneschi, Ghulam Abbas, Sonia del Prete, Clemente Capasso, Antonella Capperucci, Damiano Tanini, Fabrizio Carta, Claudiu T. Supuran
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 2, p 598 (2020)
A series of 2-thio- and 2-seleno-acetamides bearing the benzenesulfonamide moiety were evaluated as Carbonic Anhydrase (CA, EC 4.2.1.1) inhibitors against different pathogenic bacteria such as the Vibrio cholerae (VchCA-α and VchCA-β), Burkholderia
Externí odkaz:
https://doaj.org/article/606f97b9163f41f6a5832a0dcffd2a02
Autor:
Dragos Lucian Isac, Tudor Vasiliu, Andrei Neamtu, Aatto Laaksonen, Stelian S. Maier, Bogdan Florin Craciun, Francesca Mocci, Mariana Pinteala, Lilia Clima
Publikováno v:
Biomaterials Science. 9:6623-6640
Biocompatible hydrophilic polyethylene glycol (PEG) is widely used in biomedical applications, such as drug or gene delivery, tissue engineering or as an antifouling component in biomedical devices. Experimental studies have shown that the size of PE