Semisynthetic guanidino lipoglycopeptides with potent in vitro and in vivo antibacterial activity.

Autor: van Groesen E; Biological Chemistry Group, Institute of Biology Leiden, Leiden University, 2300 RA Leiden, Netherlands., Mons E; Biological Chemistry Group, Institute of Biology Leiden, Leiden University, 2300 RA Leiden, Netherlands., Kotsogianni I; Biological Chemistry Group, Institute of Biology Leiden, Leiden University, 2300 RA Leiden, Netherlands., Arts M; Institute for Pharmaceutical Microbiology, University Hospital Bonn, University of Bonn, 53113 Bonn, Germany., Tehrani KHME; Biological Chemistry Group, Institute of Biology Leiden, Leiden University, 2300 RA Leiden, Netherlands., Wade N; Biological Chemistry Group, Institute of Biology Leiden, Leiden University, 2300 RA Leiden, Netherlands., Lysenko V; Biological Chemistry Group, Institute of Biology Leiden, Leiden University, 2300 RA Leiden, Netherlands., Stel FM; Biological Chemistry Group, Institute of Biology Leiden, Leiden University, 2300 RA Leiden, Netherlands., Zwerus JT; Biological Chemistry Group, Institute of Biology Leiden, Leiden University, 2300 RA Leiden, Netherlands., De Benedetti S; Institute for Pharmaceutical Microbiology, University Hospital Bonn, University of Bonn, 53113 Bonn, Germany., Bakker A; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, 2300 RA Leiden, Netherlands., Chakraborty P; Department of Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9700 AB Groningen, Netherlands., van der Stelt M; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, 2300 RA Leiden, Netherlands., Scheffers DJ; Department of Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9700 AB Groningen, Netherlands., Gooskens J; Department of Medical Microbiology, Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, 2333 ZA Leiden, Netherlands., Smits WK; Experimental Bacteriology, Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, 2333 ZA Leiden, Netherlands., Holden K; Evotec (U.K.) Ltd., Alderley Park, Macclesfield, Cheshire, SK10 4TG UK., Gilmour PS; The Drug Development Team, 2321 DK Leiden, Netherlands., Willemse J; Institute of Biology Leiden, Leiden University, 2300 RA Leiden, Netherlands., Hitchcock CA; 6 Carnoustie Close, Molehill Road, Chestfield, Whitstable, Kent CT5 3PW, UK., van Hasselt JGC; Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, 2300 RA Leiden, Netherlands., Schneider T; Institute for Pharmaceutical Microbiology, University Hospital Bonn, University of Bonn, 53113 Bonn, Germany., Martin NI; Biological Chemistry Group, Institute of Biology Leiden, Leiden University, 2300 RA Leiden, Netherlands.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Aug 07; Vol. 16 (759), pp. eabo4736. Date of Electronic Publication: 2024 Aug 07.