Compartmentalization of GABA synthesis by GAD67 differs between pancreatic beta cells and neurons.

Autor: Jamil Kanaani, Chiara Cianciaruso, Edward A Phelps, Miriella Pasquier, Estelle Brioudes, Nils Billestrup, Steinunn Baekkeskov

Publikováno v: PLoS ONE, Vol 10, Iss 2, p e0117130 (2015)

The inhibitory neurotransmitter GABA is synthesized by the enzyme glutamic acid decarboxylase (GAD) in neurons and in pancreatic β-cells in islets of Langerhans where it functions as a paracrine and autocrine signaling molecule regulating the functi

Externí odkaz: https://doaj.org/article/54cfc48a6fce459f8a64f05cd627b1de

Correction: Corrigendum: Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation

Autor: Edward A. Phelps, Chiara Cianciaruso, Jaime Santo-Domingo, Miriella Pasquier, Gabriele Galliverti, Lorenzo Piemonti, Ekaterine Berishvili, Olivier Burri, Andreas Wiederkehr, Jeffrey A. Hubbell, Steinunn Baekkeskov

Publikováno v: Scientific Reports

A robust and reproducible method for culturing monolayers of adherent and well-spread primary islet cells on glass coverslips is required for detailed imaging studies by super-resolution and live-cell microscopy. Guided by an observation that dispers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e9f01a640b1b282bd336282eba67dc
https://doi.org/10.1038/srep46801

Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation

Autor: Jaime Santo-Domingo, Andreas Wiederkehr, Gabriele Galliverti, Jeffrey A. Hubbell, Olivier Burri, Steinunn Baekkeskov, Lorenzo Piemonti, Chiara Cianciaruso, Edward A. Phelps, Ekaterine Berishvili, Miriella Pasquier

Publikováno v: Scientific reports, vol 7, iss 1
Scientific Reports, Vol. 7 (2017) P. 45961

A robust and reproducible method for culturing monolayers of adherent and well-spread primary islet cells on glass coverslips is required for detailed imaging studies by super-resolution and live-cell microscopy. Guided by an observation that dispers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb1f6f98ef2efea098cabd28c53a29d
https://escholarship.org/uc/item/629576cw

Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity

Autor: Mohamed Alibashe Ahmed, Miriella Pasquier, Jeffrey A. Hubbell, Chiara Cianciaruso, Steinunn Baekkeskov, Edward A. Phelps, Romain Hamelin, Melody A. Swartz, Michele De Palma, Davide Demurtas, Lorenzo Piemonti, Sachiko Hirosue

Publikováno v: Diabetes. 66(2)

The target autoantigens in several organ-specific autoimmune diseases, including type 1 diabetes (T1D), are intracellularmembrane proteins, whose initial encounter with the immune system is poorly understood. Here we propose a new model for how these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8730d243546def0b83bc67fbc216a6be
https://pubmed.ncbi.nlm.nih.gov/27872147

Compartmentalization of GABA Synthesis by GAD67 Differs between Pancreatic Beta Cells and Neurons

Autor: Miriella Pasquier, Steinunn Baekkeskov, Edward A. Phelps, Chiara Cianciaruso, Estelle Brioudes, Nils Billestrup, Jamil Kanaani

Publikováno v: PLOS ONE, Vol. 10, No 2 (2015) P. e0117130
Baekkeskov, Steinunn; Kanaani, J; Cianciaruso, C; Phelps, EA; Pasquier, M; Brioudes, E; et al.(2015). Compartmentalization of GABA synthesis by GAD67 differs between pancreatic beta cells and neurons. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/45t7z94w
PLoS ONE, Vol 10, Iss 2, p e0117130 (2015)
PLoS ONE

The inhibitory neurotransmitter GABA is synthesized by the enzyme glutamic acid decarboxylase (GAD) in neurons and in pancreatic β-cells in islets of Langerhans where it functions as a paracrine and autocrine signaling molecule regulating the functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::993d4527872fea205b2f6f9ff0580581
https://archive-ouverte.unige.ch/unige:90598