A Structural Mechanism for Noncanonical GPCR Signal Transduction in the Hedgehog Pathway.

Autor: Steiner WP; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA., Iverson N; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA., Venkatakrishnan V; Department of Chemistry, Pennsylvania State University, University Park, PA, USA., Wu J; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA., Stepniewski TM; Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM) - Pompeu Fabra University (UPF), Dr Aiguader 88, Barcelona, Spain.; InterAx Biotech AG, Villigen, Switzerland., Michaelson Z; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA., Bröckel JW; Institute for Biology, Department of Biochemistry, University of Kassel, Kassel, Germany., Zhu JF; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA., Bruystens J; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA., Lee A; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA., Nelson I; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA., Bertinetti D; Institute for Biology, Department of Biochemistry, University of Kassel, Kassel, Germany., Arveseth CD; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA., Tan G; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA., Spaltenstein P; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Xu J; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA., Hüttenhain R; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Kay M; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Herberg FW; Institute for Biology, Department of Biochemistry, University of Kassel, Kassel, Germany., Selent J; Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM) - Pompeu Fabra University (UPF), Dr Aiguader 88, Barcelona, Spain., Anand GS; Department of Chemistry, Pennsylvania State University, University Park, PA, USA.; The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA., Dunbrack RL Jr; Institute for Cancer Research. Fox Chase Cancer Center. Philadelphia PA, USA., Taylor SS; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA., Myers BR; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Nov 01. Date of Electronic Publication: 2024 Nov 01.