The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling

Autor: Su, X., Floyd, D. H., Hughes, A., Xiang, J., Schneider, Jochen, Uluckan, O., Heller, E., Deng, H., Zou, W., Craft, C. S., Wu, K., Hirbe, A. C., Grabowska, D., Eagleton, M. C., Townsley, S., Collins, L., Piwnica-Worms, D., Steinberg, T. H., Novack, D. V., Conley, P. B., Hurchla, M. A., Rogers, M., Weilbaecher, K. N.

Publikováno v: Journal of Clinical Investigation, 122(10), 3579-3592. Ann Arbor, MI: American Society for Clinical Investigation (2012).

The adenosine diphosphate (ADP) receptor P2RY12 (purinergic receptor P2Y, G protein coupled, 12) plays a critical role in platelet aggregation, and P2RY12 inhibitors are used clinically to prevent cardiac and cerebral thrombotic events. Extracellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2658::d2eb654ae6acc6546104b173ae315734
http://orbilu.uni.lu/handle/10993/27289

The roles of RGS proteins in cardiometabolic disease.

Autor: McNeill SM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Zhao P; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-Electron Microscopy of Membrane Proteins (CCeMMP), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2024 Jul; Vol. 181 (14), pp. 2319-2337. Date of Electronic Publication: 2023 Apr 19.

Association with ZO-1 correlates with plasma membrane partitioning in truncated connexin45 mutants.

Autor: Laing, J G, Koval, M, Steinberg, T H

Publikováno v: Journal of Membrane Biology; Sep2005, Vol. 207 Issue 3, p45-53, 9p

Fura-2 secretion and sequestration in macrophages. A blocker of organic anion transport reveals that these processes occur via a membrane transport system for organic anions

Autor: Francesco Di Virgilio, Steinberg, T. H., Swanson, J. A., Silverstein, S. C.

Publikováno v: Scopus-Elsevier

Fura-2, loaded into J774.2 macrophages as the acetoxymethyl ester, is sequestered into intracellular vacuoles within 90 min after the beginning of the loading at 37 degrees C. The dye is also efficiently secreted from the cells. Sequestration and sec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e95df44272da43a9a3285e8546dc652c
https://doi.org/10.4049/jimmunol.140.3.915

Extracellular nucleotides mediate Ca2+ fluxes in J774 macrophages by two distinct mechanisms.

Autor: Greenberg, S, Di Virgilio, F, Steinberg, T H, Silverstein, S C

Publikováno v: Journal of Biological Chemistry; July 1988, Vol. 263 Issue: 21 p10337-10343, 7p