Structured Moderate Exercise and Biomarkers of Kidney Health in Sedentary Older Adults: The Lifestyle Interventions and Independence for Elders Randomized Clinical Trial

Autor: Anoop Sheshadri, Mason Lai, Fang-Chi Hsu, Scott R. Bauer, Shyh-Huei Chen, Warren Tse, Vasantha Jotwani, Gregory J. Tranah, Jennifer C. Lai, Stein Hallan, Roger A. Fielding, Christine Liu, Joachim H. Ix, Steven G. Coca, Michael G. Shlipak

Publikováno v: Kidney Medicine, Vol 5, Iss 11, Pp 100721- (2023)

Rationale & Objective: In the Lifestyle Interventions and Independence for Elders (LIFE) trial, a structured exercise intervention slowed kidney function decline in sedentary older adults. Biomarkers of kidney health could distinguish potential mecha

Externí odkaz: https://doaj.org/article/7689ea230d60456abbb9651bd79e38cd

Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals

Autor: Kira J. Stanzick, Yong Li, Pascal Schlosser, Mathias Gorski, Matthias Wuttke, Laurent F. Thomas, Humaira Rasheed, Bryce X. Rowan, Sarah E. Graham, Brett R. Vanderweff, Snehal B. Patil, VA Million Veteran Program, Cassiane Robinson-Cohen, John M. Gaziano, Christopher J. O’Donnell, Cristen J. Willer, Stein Hallan, Bjørn Olav Åsvold, Andre Gessner, Adriana M. Hung, Cristian Pattaro, Anna Köttgen, Klaus J. Stark, Iris M. Heid, Thomas W. Winkler

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Identifying causal variants and genes in genome-wide association studies remains a challenge, an issue that is ameliorated with larger sample sizes. Here the authors meta-analyze kidney function genome-wide association studies to identify new loci an

Externí odkaz: https://doaj.org/article/f9a7445b1e5c4729b2f89352fcb65ca1

Metabolomics and Gene Expression Analysis Reveal Down-regulation of the Citric Acid (TCA) Cycle in Non-diabetic CKD Patients

Autor: Stein Hallan, Maryam Afkarian, Leila R. Zelnick, Bryan Kestenbaum, Shoba Sharma, Rintaro Saito, Manjula Darshi, Gregory Barding, Daniel Raftery, Wenjun Ju, Matthias Kretzler, Kumar Sharma, Ian H. de Boer

Publikováno v: EBioMedicine, Vol 26, Iss C, Pp 68-77 (2017)

Chronic kidney disease (CKD) is a public health problem with very high prevalence and mortality. Yet, there is a paucity of effective treatment options, partly due to insufficient knowledge of underlying pathophysiology. We combined metabolomics (GCM

Externí odkaz: https://doaj.org/article/a4d0f131e2714adf87397a4be51fc2bb

Direction- and Angle-Assisted Buttonhole Cannulation of Arteriovenous Fistula in Hemodialysis Patients: A Multicenter Randomized Controlled Trial

Autor: Maria Hultstrøm, Marit I. Rønning, Pim Benschop, Stein Hallan, Marius Altern Øvrehus

Publikováno v: Kidney Medicine

Rationale & objective: Arteriovenous fistula cannulation with the buttonhole technique is often preferred by patients but has been associated with an increased infection risk. Guidelines disagree on whether it should be abandoned, thus we assessed a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2241027e57bcd6c386617a69ce09976c
https://pubmed.ncbi.nlm.nih.gov/35243305

Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease

Autor: Hong Zhang, Humaira Rasheed, Yukinori Okada, Iona Y Millwood, Zhengming Chen, Tom R. Gaunt, George Davey Smith, Yoichiro Kamatani, Venexia M Walker, Philip C Haycock, Andrew P. Morris, Jie Zheng, Cristian Pattaro, Robyn E Wootton, Yuka Sugawara, Amy E Howell, Masato Akiyama, Koichi Matsuda, Sean J. Barbour, Nora Franceschini, Masahiro Kanai, Matthias Wuttke, Si Fang, Masayuki Yamamoto, Jiachen Li, Naoki Kashihara, Ben Michael Brumpton, Laurent F. Thomas, Maria Carolina Borges, Rebecca Carnegie, Jamie Robinson, Yue-miao Zhang, Stein Hallan, Canqing Yu, Benjamin Elsworth, Stephen Burgess, Yue Leng, Kristian Hveem, Robin G Walters, Yoonsu Cho, Anna Köttgen, Bjørn Olav Åsvold, Qian Yang

Publikováno v: Zheng, J, Zhang, Y, Rasheed, H, Walker, V M, Sugawara, Y, Li, J, Leng, Y, Elsworth, B L, Wootton, R E, Fang, S, Yang, Q, Burgess, S, Haycock, P C, Borges, M C, Cho, Y, Carnegie, R, Howell, A E, Robinson, J W, Thomas, L, Brumpton, B M, Hveem, K, Hallan, S, Franceschini, N, Morris, A, Köttgen, A, Pattaro, C, Wuttke, M, Yamamoto, M, Kashihara, N, Akiyama, M, Kanai, M, Matsuda, K, Kamatani, Y, Okada, Y, Walters, R, Millwood, I, Chen, Z, Davey Smith, G, Barbour, S, Yu, C, Åsvold, B O, Zhang, H & Gaunt, T R 2021, ' Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease ', International Journal of Epidemiology, vol. 50, no. 6, pp. 1995-2010 . https://doi.org/10.1093/ije/dyab203
International Journal of Epidemiology

Funder: Government Department of Business
Funder: Energy and Industrial Strategy (BEIS)
Funder: Vice-Chancellor Fellowship from the University of Bristol
Funder: Shanghai Thousand Talents Program
Funder: Academy of Medical Science

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ad61d2f9c0bf562a39300875218aa6
https://research-information.bris.ac.uk/ws/files/312545151/dyab203.pdf