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Akademický článek
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Autor:
Nina Zablowsky, Lydia Farack, Sven Rofall, Jan Kramer, Hanna Meyer, Duy Nguyen, Alexander K. C. Ulrich, Benjamin Bader, Patrick Steigemann
Publikováno v:
Non-Coding RNA, Vol 9, Iss 1, p 2 (2023)
Traditionally, small molecule-based drug discovery has mainly focused on proteins as the drug target. Opening RNA as an additional target space for small molecules offers the possibility to therapeutically modulate disease-driving non-coding RNA targ
Externí odkaz:
https://doaj.org/article/e79d668e99ed488b92e56257b78722a6
Autor:
Clara Lemos, Luise Schulze, Joerg Weiske, Hanna Meyer, Nico Braeuer, Naomi Barak, Uwe Eberspächer, Nicolas Werbeck, Carlo Stresemann, Martin Lange, Ralf Lesche, Nina Zablowsky, Katrin Juenemann, Atanas Kamburov, Laura Martina Luh, Thomas Markus Leissing, Jeremie Mortier, Michael Steckel, Holger Steuber, Knut Eis, Ashley Eheim, Patrick Steigemann
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101517- (2020)
Summary: Structural mutants of p53 induce global p53 protein destabilization and misfolding, followed by p53 protein aggregation. First evidence indicates that p53 can be part of protein condensates and that p53 aggregation potentially transitions th
Externí odkaz:
https://doaj.org/article/a212af021eff409c84704cd1ec1f0308
Autor:
Anna Steigemann
Publikováno v:
Cosmopolitan Civil Societies: An Interdisciplinary Journal, Vol 12, Iss 1 (2020)
Based on an extensive ethnography of the economic and social life in Berlin-Neukölln, the paper asks how a changing demographic and social structure affects the social life but also the urban renewal on two iconic but contested streets - “the Arab
Externí odkaz:
https://doaj.org/article/48650072441c48fcbf5560d7849fd6d5
Publikováno v:
Urban Planning, Vol 3, Iss 4, Pp 64-78 (2018)
With the increase of refugee movements since 2014 in Europe and the Near East, the debate of how to plan appropriate shelters and emergency accommodation has gained a new momentum. Established techno-managerial approaches have been criticised as inap
Externí odkaz:
https://doaj.org/article/45679db1222b4ea0bca376dafecb9409
Publikováno v:
SoftwareX, Vol 7, Iss , Pp 1-5 (2018)
libxc is a library of exchange–correlation functionals for density-functional theory. We are concerned with semi-local functionals (or the semi-local part of hybrid functionals), namely local-density approximations, generalized-gradient approximati
Externí odkaz:
https://doaj.org/article/f46c84850eb84968ac20479cfe466298
Autor:
A. M. Steigemann
Publikováno v:
Geographica Helvetica, Vol 72, Iss 1, Pp 45-54 (2017)
The transformations of economic structures as well as of transportation and communication means have altered neighborhood-based interaction in the last decades. Therefore most urban studies argue that local neighborhoods have lost their function as p
Externí odkaz:
https://doaj.org/article/43baf2b61fd841a785354ff87db53d3e
Publikováno v:
Urban Planning, 3, 4, 64-78, European Cities Planning for Asylum
With the increase of refugee movements since 2014 in Europe and the Near East, the debate of how to plan appropriate shelters and emergency accommodation has gained a new momentum. Established techno-managerial approaches have been criticised as inap
Externí odkaz:
https://www.ssoar.info/ssoar/handle/document/60862
Autor:
Christian Gentili, Dennis Castor, Svenja Kaden, David Lauterbach, Mario Gysi, Patrick Steigemann, Daniel W Gerlich, Josef Jiricny, Stefano Ferrari
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133576 (2015)
RUVBL1 (RuvB-like1) and RUVBL2 (RuvB-like 2) are integral components of multisubunit protein complexes involved in processes ranging from cellular metabolism, transcription and chromatin remodeling to DNA repair. Here, we show that although RUVBL1 an
Externí odkaz:
https://doaj.org/article/f22ec71c23ea48f497742d4dbf7ebb68