Zobrazeno 1 - 10
of 884
pro vyhledávání: '"Stege, P."'
Quantum computing has the potential to surpass the capabilities of current classical computers when solving complex problems. Combinatorial optimization has emerged as one of the key target areas for quantum computers as problems found in this field
Externí odkaz:
http://arxiv.org/abs/2307.14308
Autor:
Philipp Licht, Nazzareno Dominelli, Johannes Kleemann, Stefan Pastore, Elena-Sophia Müller, Maximilian Haist, Kim Sophie Hartmann, Henner Stege, Matthias Bros, Markus Meissner, Stephan Grabbe, Ralf Heermann, Volker Mailänder
Publikováno v:
npj Biofilms and Microbiomes, Vol 10, Iss 1, Pp 1-17 (2024)
Abstract Mycosis fungoides (MF) is the most common entity of Cutaneous T cell lymphomas (CTCL) and is characterized by the presence of clonal malignant T cells in the skin. The role of the skin microbiome for MF development and progression are curren
Externí odkaz:
https://doaj.org/article/ac23a0518b51423d9ef037eec3ac22ce
Autor:
Zaborniak, Tristan, Stege, Ulrike
Many computational problems involve optimization over discrete variables with quadratic interactions. Known as discrete quadratic models (DQMs), these problems in general are NP-hard. Accordingly, there is increasing interest in encoding DQMs as quad
Externí odkaz:
http://arxiv.org/abs/2305.00568
Autor:
Nathalie Beaufort, Linda Ingendahl, Melisa Merdanovic, Andree Schmidt, David Podlesainski, Tim Richter, Thorben Neumann, Michael Kuszner, Ingrid R. Vetter, Patricia Stege, Steven G. Burston, Anto Filipovic, Yasser B. Ruiz-Blanco, Kenny Bravo-Rodriguez, Joel Mieres-Perez, Christine Beuck, Stephan Uebel, Monika Zobawa, Jasmin Schillinger, Rainer Malik, Katalin Todorov-Völgyi, Juliana Rey, Annabell Roberti, Birte Hagemeier, Benedikt Wefers, Stephan A. Müller, Wolfgang Wurst, Elsa Sanchez-Garcia, Alexander Zimmermann, Xiao-Yu Hu, Tim Clausen, Robert Huber, Stefan F. Lichtenthaler, Carsten Schmuck, Michael Giese, Markus Kaiser, Michael Ehrmann, Martin Dichgans
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Loss-of-function mutations in the homotrimeric serine protease HTRA1 cause cerebral vasculopathy. Here, we establish independent approaches to achieve the functional correction of trimer assembly defects. Focusing on the prototypical R274Q m
Externí odkaz:
https://doaj.org/article/ecefd6f18eff4edf90c7e557870791d5
Autor:
Juliane Hannemann, Anne Zink, Yoana Mileva, Paul Balfanz, Edgar Dahl, Sonja Volland, Thomas Illig, Edzard Schwedhelm, Florian Kurth, Alexandra Stege, Martin Aepfelbacher, Armin Hoffmann, Rainer Böger
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Mortality of patients hospitalized with COVID-19 has remained high during the consecutive SARS-CoV-2 pandemic waves. Early discrimination of patients at high mortality risk is crucial for optimal patient care. Symmetric (SDMA) and asymmetric
Externí odkaz:
https://doaj.org/article/fd19c5f66dfd4915bcc8f54205a52bc6
Autor:
Paul B. Stege, Dirkjan Schokker, Frank Harders, Soumya K. Kar, Norbert Stockhofe, Vera Perricone, Johanna M. J. Rebel, Ingrid C. de Jong, Alex Bossers
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract Modern broiler breeds allow for high feed efficiency and rapid growth, which come at a cost of increased susceptibility to pathogens and disease. Broiler growth rate, feed efficiency, and health are affected by the composition of the gut mic
Externí odkaz:
https://doaj.org/article/8cbddbb66af1493b9c2392b3f8c520a3
RNAs self-interact through hydrogen-bond base-pairing between nucleotides and fold into specific, stable structures that substantially govern their biochemical behaviour. Experimental characterization of these structures remains difficult, hence the
Externí odkaz:
http://arxiv.org/abs/2208.04367
Autor:
Kazimierz Groen, Febe Smits, Kazem Nasserinejad, Mark‐David Levin, Josien C. Regelink, Gert‐Jan Timmers, Esther G. M. deWaal, Matthijs Westerman, Gerjo A. Velders, Koen deHeer, Rineke B. L. Leys, Roel J. W. vanKampen, Claudia A. M. Stege, Maarten R. Seefat, Inger S. Nijhof, Ellen van derSpek, Saskia K. Klein, Niels W. C. J. van deDonk, Paula F. Ypma, Sonja Zweegman
Publikováno v:
HemaSphere, Vol 8, Iss 7, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/35ff82dc826f4e589fe20f0d84490eb9
Autor:
Ying Wang, Carolin Ertl, Christina Schmitt, Linda Hammann, Rafaela Kramer, Ulrich Grabmaier, Florian Schöberl, David Anz, Ignazio Piseddu, Giulia Pesch, Julio Vera, Waltraud Froehlich, Ludwig Weckbach, Dirk Tomsitz, Carmen Loquai, Lisa Zimmer, Johanna Mangana, Reinhard Dummer, Ralf Gutzmer, Kai-Christian Klespe, Henner Stege, Frank Meiss, Kai-Martin Thoms, Patrick Terheyden, Paul J. Bröckelmann, Douglas B. Johnson, Lars E. French, Lucie Heinzerling
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
BackgroundImmune checkpoint inhibitor (ICI)-induced myocarditis is a rare immune-related adverse event (irAE) with a fatality rate of 40%–46%. However, irMyocarditis can be asymptomatic. Thus, improved monitoring, detection and therapy are needed.
Externí odkaz:
https://doaj.org/article/0d24ababd2e842d890215bef5ee1389e
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 5, p e1011787 (2024)
Understanding and targeting functional RNA structures towards treatment of coronavirus infection can help us to prepare for novel variants of SARS-CoV-2 (the virus causing COVID-19), and any other coronaviruses that could emerge via human-to-human tr
Externí odkaz:
https://doaj.org/article/ac2e740f7558420cbf1a78460fb08641