Výsledky vyhledávání

Syntheses of novel modified acyclic purine and pyrimidine nucleosides as potential substrates of herpes simplex virus type-1 thymidine kinase for monitoring gene expression

Autor: Bernd Johannsen, Michaela Grote, Bernhard Noll, Werner Kraus, Steffi Noll

Publikováno v: Canadian Journal of Chemistry. 82:513-523

Suicide gene therapy with the herpes simplex virus type-1 thymidine kinase gene (HSV-1 tk) is considered to be a promising approach to the treatment of cancer. Making use of the lower specificity of the viral enzyme compared to human thymidine kinase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b0e6a3f7b7c6aa84efb654b65c3689f
https://doi.org/10.1139/v04-005

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Technetium and rhenium complexes of mercaptoacetyl glycine ligands 2. Formation and molecular structure of Re(V) complexes with mercaptoacetyl glycine and mercaptoacetyl glycine ethylester

Autor: Bernd Johannsen, Peter Leibnitz, Hartmut Spies, Paul E. Schulze, Bernhard Noll, Wolfhard Semmler, Steffi Noll

Publikováno v: Inorganica Chimica Acta 255 (1997) 399-403

Reaction of [ReOCl 4 ] − with mercaptoacetyl glycine (MAG 1 ) in a 1:1 ratio gives [ReO(MAG 1 )Cl] − . Using an excess of the ligand in ethanol, a neutral oxorhenium(V) complex [ReO(MAGEt 1 ) 2 ] is formed where the metal is coordinated by S and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa71996fcfa2083ada806b7ecee6d810
https://doi.org/10.1016/s0020-1693(96)05389-3

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Technetium and rhenium complexes of mercapto-containing peptides 1. Tc(V) and Re(V) complexes with mercaptoacetyl diglycine (MAG2) and X-ray structure of AsPh4[TcO(MAG2)]·C2H5OH

Autor: Peter Leibnitz, Bernhard Noll, Steffi Noll, Bernd Johannsen, Günter Reck, Hartmut Spies

Publikováno v: Inorganica Chimica Acta. 210:209-214

The reaction of mercaptoacetyl diglycine (MAG 2 ) with technetium(V) gluconate in aqueous solution produced [TcO(MAG 2 )] − . A single X-ray structure determination was carried out for the tetraphenylarsonium salt. The dark brown crystals are monoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27fb72d33b9e626abd4e5662a148f023
https://doi.org/10.1016/s0020-1693(00)83329-0

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A novel tetrabranched neurotensin(8-13) cyclam derivative: synthesis, 64Cu-labeling and biological evaluation

Autor: Ralf Bergmann, Jens Pietzsch, Steffi Noll, Jörg Steinbach, Holger Stephan, Anne Kretzschmann, Anika Röhrich

Publikováno v: Journal of Inorganic Biochemistry 105(2011), 821-832

New macrocyclic 1,4,8,11-tetraazacyclotetradecane (cyclam) derivatives with 1, 2 and 4 neurotensin(8-13) units 4, 5 and 7 have been synthesized. Compounds 4 and 5 were prepared by the reaction of non-stabilized neurotensin(8-13) and cyclam tetrapropi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd0ac716baebc79de27868a68fb7a2ea
https://pubmed.ncbi.nlm.nih.gov/21497581

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Two mononuclear Tc complexes: [2,2'-(3-phenylpropylimino)- and [2,2'-(propylimino)bis(ethanethiolato)](4-methoxybenzenethiolato)oxidotechnate(V)

Autor: Franziska Emmerling, Hans-Jürgen Pietzsch, Werner Kraus, Bernhard Noll, Steffi Noll

Publikováno v: Acta crystallographica. Section C, Crystal structure communications. 63(Pt 12)

The molecular structures of the two mononuclear title complexes, namely (4-methoxybenzenethiolato-kappaS)oxido[2,2'-(3-phenylpropylimino)bis(ethanethiolato)-kappa(3)S,N,S']technetium(V), [Tc(C14H21NS2)(C7H7OS)O], (I), and (4-methoxybenzenethiolato-ka

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb52516bac3fad84afeb642c86c5b39b
https://pubmed.ncbi.nlm.nih.gov/18057600

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Carbohydration of 1,4,8,11-tetraazacyclotetradecane (cyclam): synthesis and binding properties toward concanavalin A

Autor: Holger Stephan, Ralf Kirchner, Anika Röhrich, Jörg Steinbach, Steffi Noll, Jürgen Seidel

Publikováno v: Tetrahedron Letters 48(2007), 8834-8838

Two novel glycocluster ligands with cyclam core bearing thiourea-linked d -glucose and 2-acetamido-2-deoxy- d -glucose at the periphery have been synthesized. The interaction with concanavalin A has been studied by isothermal titration microcalorimet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd10b0833205308c87ddd0911a151036
https://www.hzdr.de/publications/Publ-10412-1

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Synthesis and Molecular Structure of a Rhenium Complex Derived from 8a‐Amino‐6‐methyl‐ergoline

Autor: Paul E. Schulze, Steffi Noll, Bernhard Noll, Matthias Findeisen, Bernd Johannsen, Peter Leibnitz, Hartmut Spies

Publikováno v: Chemische Berichte. 130:839-841

Current research in radiopharmaceutical chemistry is aimed at the design of technetium-based receptor-binding radiotracers because of the excellent nuclide properties of the isotope 99mTc. Tc tracers and the corresponding complexes of rhenium, as the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71ceb48a62c0ece9cfc78ee981c46662
https://doi.org/10.1002/cber.19971300705

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PET of cardiac transgene expression: comparison of 2 approaches based on herpesviral thymidine kinase reporter gene

Autor: Masao, Miyagawa, Martina, Anton, Roland, Haubner, Marcus V, Simoes, Christian, Städele, Wolf, Erhardt, Sybille, Reder, Terry, Lehner, Bettina, Wagner, Steffi, Noll, Bernhard, Noll, Michaela, Grote, Sanjiv S, Gambhir, Bernd, Gansbacher, Markus, Schwaiger, Frank M, Bengel

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 45(11)

PET of reporter gene expression holds promise for noninvasive monitoring of gene therapy. Previously, 2 approaches based on the herpes simplex virus type 1 thymidine kinase gene (HSV1-tk) have been successfully applied to the heart. Wild-type HSV1-tk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::02a14d260b99c4a5ee9965dae7f72cd2
https://pubmed.ncbi.nlm.nih.gov/15534063

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Coexpression of herpesviral thymidine kinase reporter gene and VEGF gene for noninvasive monitoring of therapeutic gene transfer: an in vitro evaluation

Autor: Martina, Anton, Constanze, Wittermann, Roland, Haubner, Marcus, Simoes, Sybille, Reder, Bryan, Essien, Bettina, Wagner, Julia, Henke, Wolf, Erhardt, Steffi, Noll, Neil R, Hackett, Ronald G, Crystal, Markus, Schwaiger, Bernd, Gansbacher, Frank M, Bengel

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 45(10)

Coexpression of a reporter gene and a therapeutic gene may allow for noninvasive monitoring of cardiac gene therapy. We sought to evaluate the usefulness of an adenoviral vector expressing mutant herpesviral thymidine kinase reporter gene (HSV1-sr39t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fc9bc93e561108863a3c1e0be540c338
https://pubmed.ncbi.nlm.nih.gov/15471843

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Comparison of [18F]FHPG and [124/125I]FIAU for imaging herpes simplex virus type 1 thymidine kinase gene expression

Autor: Steffi Noll, Hans K. Schackert, Bernd Johannsen, Norbert Avril, Roland Haubner, Peter Brust, Anne Friedrich, Uwe Haberkorn, Martina Anton, Olga Niki Koufaki, Bernhard Noll, Matthias Scheunemann, Martin Hauses, Gabriele Schackert

Publikováno v: European journal of nuclear medicine. 28(6)

Various radiotracers based on uracil nucleosides (e.g. [124I]2'-fluoro-2'-deoxy-5-iodo-1-beta-D-arabinofuranosyluracil, [124I]FIAU) and acycloguanosine derivatives (e.g. [18F]9-[(3-fluoro-1-hydroxy-2-propoxy) methyl] guanine, [18F]FHPG) have been pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c317d549870014792ca48928648cd2
https://pubmed.ncbi.nlm.nih.gov/11440032

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