Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Steffi Harlfinger"'
Autor:
Kevin Beaumont, Andy Pike, Michael Davies, Adriana Savoca, Christina Vasalou, Steffi Harlfinger, Diane Ramsden, Douglas Ferguson, Niresh Hariparsad, Owen Jones, Dermot McGinnity
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems.
The therapeutic concept of antibody drug conjugates (ADCs) is to selectively target tumour cells with small molecule cytotoxic drugs to maximise cell kill benefit and minimise healthy tissue toxicity.An ADC generally consists of an antibody that targ
Autor:
Edgar Schömig, Adnan Kastrati, Andreas Lazar, Albert Schömig, Nicolas von Beckerath, Steffi Harlfinger, Dirk Taubert, Olga Gorchakova
Publikováno v:
Thrombosis and Haemostasis. 92:311-316
SummaryThe adenosine diphosphate (ADP) receptor P2Y12 blocking agent clopidogrel is clinically proven to be efficient in preventing thrombotic events. However, its therapeutic value is limited by an, as yet poorly explained, interindividual heterogen
Autor:
Reinhard Berkels, Dirk Taubert, Thomas Breitenbach, Petra Censarek, Wolfgang Klaus, Steffi Harlfinger, Renate Roesen, Andreas Lazar
Publikováno v:
Taubert, D, Breitenbach, T, Lazar, A, Censarek, P, Harlfinger, S, Berkels, R, Klaus, W & Roesen, R 2003, ' Reaction rate constants of superoxide scavenging by plant antioxidants ', Free Radical Biology and Medicine, vol. 35, no. 12, pp. 1599-1607 . https://doi.org/10.1016/j.freeradbiomed.2003.09.005
Plant phenols may exert protective effects by scavenging superoxide, which is implicated in tissue damage and accelerated inactivation of vasorelaxing nitric oxide. Preventing the interaction of superoxide with tissue biomolecules depends not only on
Effect of propiverine on cytochrome P450 enzymes: a cocktail interaction study in healthy volunteers
Autor:
Dirk Kasel, Uwe Fuhr, Alexander Jetter, Julia Kirchheiner, Tobias Klaassen, Martina Kinzig-Schippers, Doro Frank, Dorota Tomalik-Scharte, Manfred Brater, Steffi Harlfinger, Andreas Skott, Thomas Gramatté, Fritz Sörgel, Oxana Doroshyenko, Klaus Richter
Publikováno v:
Drug Metabolism and Disposition.
The present study was conducted to assess a possible in vivo effect of propiverine, an anticholinergic drug to treat urinary incontinence and related disorders, on the activity of intestinal CYP3A4 and of hepatic CYP3A4, CYP2C9, CYP2C19, and CYP1A2.
Autor:
Alexander Jetter, Carsten Müller, M. Theisohn, Oxana Doroshyenko, Fritz Hering, Steffi Harlfinger, Wolf Kremer, Bernhard Roth, Christoph Hünseler
Publikováno v:
European journal of pediatrics. 165(4)
Piritramide is indicated for treatment of postoperative pain and analgosedation in the intensive care unit (ICU) setting. In an open prospective study the pharmacokinetics of piritramide were investigated in four groups: newborns (NB, age: 1-28 days)
Publikováno v:
Rapid communications in mass spectrometry : RCM. 18(13)
A reliable and easy to use liquid chromatography/tandem mass spectrometry (LC/MS/MS) method was developed for the simultaneous quantification of urinary concentrations of cyclophosphamide (CP) and its main metabolites excreted in urine, i.e. N-dechlo
Publikováno v:
Journal of agricultural and food chemistry. 52(9)
Consistent evidence suggests that the probable human carcinogen acrylamide is formed in starch-rich foodstuffs through heat-induced interaction of asparagine and reducing sugars during Maillard browning. However, information regarding the influence o