Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Steffi, Klier"'
Autor:
Catia Caetano, Oliver Limbo, Sarah Farmer, Steffi Klier, Claire Dovey, Paul Russell, Robertus Antonius Maria de Bruin
Publikováno v:
Cell Reports, Vol 9, Iss 6, Pp 2279-2289 (2014)
Expression of a G1/S regulon of genes that are required for DNA replication is a ubiquitous mechanism for controlling cell proliferation; moreover, the pathological deregulated expression of E2F-regulated G1/S genes is found in every type of cancer.
Externí odkaz:
https://doaj.org/article/2e06dcf3965e4590949425e03f73f6db
Autor:
Adi Hendler, Edgar M Medina, Anastasiya Kishkevich, Mehtap Abu-Qarn, Steffi Klier, Nicolas E Buchler, Robertus A M de Bruin, Amir Aharoni
Publikováno v:
PLoS Genetics, Vol 13, Iss 5, p e1006778 (2017)
Transcriptional regulatory networks play a central role in optimizing cell survival. How DNA binding domains and cis-regulatory DNA binding sequences have co-evolved to allow the expansion of transcriptional networks and how this contributes to cellu
Externí odkaz:
https://doaj.org/article/7913f6c4194c416e9e29f1c2686a086c
Autor:
Christian Schmidt, Jeremie Fizet, Francesca Properzi, Mark Batchelor, Malin K. Sandberg, Julie A. Edgeworth, Louise Afran, Sammy Ho, Anjna Badhan, Steffi Klier, Jacqueline M. Linehan, Sebastian Brandner, Laszlo L. P. Hosszu, M. Howard Tattum, Parmjit Jat, Anthony R. Clarke, Peter C. Klöhn, Jonathan D. F. Wadsworth, Graham S. Jackson, John Collinge
Publikováno v:
Open Biology, Vol 5, Iss 12 (2015)
According to the protein-only hypothesis, infectious mammalian prions, which exist as distinct strains with discrete biological properties, consist of multichain assemblies of misfolded cellular prion protein (PrP). A critical test would be to produc
Externí odkaz:
https://doaj.org/article/d9df89cc5c84457ea1d505bc18d78e06
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17211 (2011)
BACKGROUND:In fission yeast Schizosaccharomyces pombe G1/S cell-cycle regulated transcription depends upon MBF. A negative feedback loop involving Nrm1p and Yox1p bound to MBF leads to transcriptional repression as cells exit G1 phase. However, activ
Externí odkaz:
https://doaj.org/article/e5c6b5ea12224f809e66e4fc21a09b13
Autor:
Sofia Aligianni, Daniel H Lackner, Steffi Klier, Gabriella Rustici, Brian T Wilhelm, Samuel Marguerat, Sandra Codlin, Alvis Brazma, Robertus A M de Bruin, Jürg Bähler
Publikováno v:
PLoS Genetics, Vol 5, Iss 8, p e1000626 (2009)
The regulation of the G1- to S-phase transition is critical for cell-cycle progression. This transition is driven by a transient transcriptional wave regulated by transcription factor complexes termed MBF/SBF in yeast and E2F-DP in mammals. Here we a
Externí odkaz:
https://doaj.org/article/83ff74d0a26946c9a91540581ee6e8cd
Publikováno v:
Current Biology. 23:1629-1637
Summary Background In eukaryotic cells, detection of replication stress results in the activation of the DNA replication checkpoint, a signaling cascade whose central players are the kinases ATR and Chk1. The checkpoint response prevents the accumula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8c467bac77527969fa0eabe024d6d55
https://doi.org/10.1016/j.cub.2013.06.063
https://doi.org/10.1016/j.cub.2013.06.063
Autor:
Jonathan D. F. Wadsworth, Graham S. Jackson, Anthony R. Clarke, John Collinge, Christian Schmidt, Steffi Klier, Francesca Properzi, Anjna Badhan, Peter C. Klöhn
Publikováno v:
Prion
The mouse-adapted scrapie prion strain RML is one of the most widely used in prion research. The introduction of a cell culture-based assay of RML prions, the scrapie cell assay (SCA) allows more rapid and precise prion titration. A semi-automated ve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d997281b146361ca7fd450cae1fc68a8
https://pubmed.ncbi.nlm.nih.gov/27282252
https://pubmed.ncbi.nlm.nih.gov/27282252
Autor:
Edgar M. Medina, Amir Aharoni, Nicolas E. Buchler, Robertus A. M. de Bruin, Mehtap Abu-Qarn, Anastasiya Kishkevich, Steffi Klier, Adi Hendler
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 13, Iss 5, p e1006778 (2017)
PLoS Genetics, Vol 13, Iss 5, p e1006778 (2017)
Transcriptional regulatory networks play a central role in optimizing cell survival. How DNA binding domains and cis-regulatory DNA binding sequences have co-evolved to allow the expansion of transcriptional networks and how this contributes to cellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c6983a6415365721a90487cf529ab2
https://doi.org/10.1371/journal.pgen.1006778
https://doi.org/10.1371/journal.pgen.1006778
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1170
G1-S transcriptional control involves the coordination of the expression of a large set of co-regulated genes as a function of cell cycle progression (Bertoli et al., Nat Rev Mol Cell Biol 14:518-528, 2013). Confining transcription to the G1 phase of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9c0aa735358411e5e25a5f0fb698c951
https://pubmed.ncbi.nlm.nih.gov/24906330
https://pubmed.ncbi.nlm.nih.gov/24906330
Publikováno v:
Methods in Molecular Biology ISBN: 9781493908875
G1-S transcriptional control involves the coordination of the expression of a large set of co-regulated genes as a function of cell cycle progression (Bertoli et al., Nat Rev Mol Cell Biol 14:518-528, 2013). Confining transcription to the G1 phase of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bcfea9792e2ab2b4da50011f6d83716
https://doi.org/10.1007/978-1-4939-0888-2_25
https://doi.org/10.1007/978-1-4939-0888-2_25
