Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Steffen Zobel‐Roos"'
Publikováno v:
Antibodies, Vol 7, Iss 1, p 13 (2018)
Modern biopharmaceutical products strive for small-scale, low-cost production. Continuous chromatography has shown to be a promising technology because it assures high-capacity utilization, purity and yield increases, and lower facility footprint. Me
Externí odkaz:
https://doaj.org/article/7315743e415b46dea5761784d4600cc7
Publikováno v:
Antibodies, Vol 6, Iss 4, p 24 (2017)
Downstream of pharmaceutical proteins, such as monoclonal antibodies, is mainly done by chromatography, where concentration determination of coeluting components presents a major problem. Inline concentration measurements (ICM) by Ultraviolet/Visible
Externí odkaz:
https://doaj.org/article/427b7fb7776e49a797e7584c9277cea8
Autor:
Martin Kornecki, Fabian Mestmäcker, Steffen Zobel-Roos, Laura Heikaus de Figueiredo, Hartmut Schlüter, Jochen Strube
Publikováno v:
Antibodies, Vol 6, Iss 3, p 13 (2017)
Significant progress in the manufacturing of biopharmaceuticals has been made by increasing the overall titers in the USP (upstream processing) titers without raising the cost of the USP. In addition, the development of platform processes led to a hi
Externí odkaz:
https://doaj.org/article/de75e978e8c74039b586e4742cc088ca
Publikováno v:
Processes; Volume 11; Issue 6; Pages: 1634
The simulated moving bed (SMB) is a well-established, fully continuous process for chromatographic separation of difficult tasks with overlapping peaks, but it is relatively complex. The 1-SMB, which uses only one column but includes residence time z
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba7221b22be07e755ca71279f8ca947
Autor:
Steffen Zobel-Roos, Florian Vetter, Daniel Scheps, Marcus Pfeiffer, Matthias Gunne, Oliver Boscheinen, Jochen Strube
Publikováno v:
Processes; Volume 11; Issue 5; Pages: 1401
Optimizing or debottlenecking existing production plants is a challenging task. In this case study, an existing reversed phased chromatography polishing step for peptide purification was optimized with the help of a digital twin. The existing batch c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e23be876ef3226cb7a2103cb0f8759
Autor:
Axel Schmidt, Steffen Zobel‐Roos, Heribert Helgers, Lara Lohmann, Florian Vetter, Christoph Jensch, Alex Juckers, Jochen Strube
Publikováno v:
Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing. :265-350
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68bf7fc283f66ac9cf735002d5ae00c0
https://doi.org/10.1002/9783527827343.ch9
https://doi.org/10.1002/9783527827343.ch9
Autor:
Axel Schmidt, Heribert Helgers, Florian Lukas Vetter, Steffen Zobel-Roos, Alina Hengelbrock, Jochen Strube
Publikováno v:
Processes; Volume 10; Issue 9; Pages: 1783
Vaccine supply has a bottleneck in manufacturing capacity due to operation personnel and chemicals needed. Assessment of existing mRNA (messenger ribonucleic acid) vaccine processing show needs for continuous manufacturing processes. This is enabled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42bf428afbf0c6ea3f4e4bf0032da885
Autor:
Steffen Zobel-Roos, Florian Vetter, Daniel Scheps, Marcus Pfeiffer, Matthias Gunne, Oliver Boscheinen, Jochen Strube
Publikováno v:
Processes; Volume 11; Issue 5; Pages: 1480
Many fundamental decisions in the process design of a separation task are conducted in an early stage where, unfortunately, process simulation does not have the highest priority. Subsequently, during the setup of the digital twin, dedicated experimen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da3f213e3e0453f4aecbf31d891d0d30
https://doi.org/10.3390/pr11051480
https://doi.org/10.3390/pr11051480
Autor:
Axel Schmidt, Heribert Helgers, Lara Julia Lohmann, Florian Vetter, Alex Juckers, Mourad Mouellef, Steffen Zobel‐Roos, Jochen Strube
Over the last few years rapid progress has been made in adopting well-known process modeling techniques from chemicals to biologics manufacturing. The main challenge has been analytical methods as engineers need quantitative data for their workflow.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e71715e69a8d678ee116cb7c94cbc4
https://dokumente.ub.tu-clausthal.de/receive/clausthal_mods_00002179
https://dokumente.ub.tu-clausthal.de/receive/clausthal_mods_00002179
Publikováno v:
Processes; Volume 9; Issue 12; Pages: 2121
Preparative and process chromatography is a versatile unit operation for the capture, purification, and polishing of a broad variety of molecules, especially very similar and complex compounds such as sugars, isomers, enantiomers, diastereomers, plan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::f8443ca33d51ca1f710ebe5bfafe20e0