Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Steffen Schaper"'
Autor:
Kilian Merkelbach, Steffen Schaper, Christian Diedrich, Sebastian Johannes Fritsch, Andreas Schuppert
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-22 (2023)
Abstract Electronic health records (EHRs) are used in hospitals to store diagnoses, clinician notes, examinations, lab results, and interventions for each patient. Grouping patients into distinct subsets, for example, via clustering, may enable the d
Externí odkaz:
https://doaj.org/article/3550f0b03ca9446abf4a90082240f013
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 3, p e1004773 (2016)
Mutational neighbourhoods in genotype-phenotype (GP) maps are widely believed to be more likely to share characteristics than expected from random chance. Such genetic correlations should strongly influence evolutionary dynamics. We explore and quant
Externí odkaz:
https://doaj.org/article/685fab11b49747a1abcd8f6f6a778c81
Autor:
Steffen Schaper, Ard A Louis
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e86635 (2014)
Genotype-phenotype (GP) maps specify how the random mutations that change genotypes generate variation by altering phenotypes, which, in turn, can trigger selection. Many GP maps share the following general properties: 1) The total number of genotype
Externí odkaz:
https://doaj.org/article/aff4b671e3f44712a3ffa70eb4df6f5a
Autor:
Annika R. P. Schneider, Carolin V. Schneider, Kai Markus Schneider, Vanessa Baier, Steffen Schaper, Christian Diedrich, Katrin Coboeken, Hannah Mayer, Wenyi Gu, Jonel Trebicka, Lars M. Blank, Rolf Burghaus, Joerg Lippert, Daniel J. Rader, Christoph A. Thaiss, Jan‐Frederik Schlender, Christian Trautwein, Lars Kuepfer
Publikováno v:
Liver international 42(3), 640-650 (2022). doi:10.1111/liv.15161
Liver international 42(3), 640-650 (2022). doi:10.1111/liv.15161
Published by Wiley-Blackwell, Oxford
Published by Wiley-Blackwell, Oxford
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98a74bf26157c369ef3b5f0fdc1ea29f
https://pubmed.ncbi.nlm.nih.gov/35294103
https://pubmed.ncbi.nlm.nih.gov/35294103
Autor:
Stephan Menz, Steffen Schaper, Jessica Hey, Sebastian Schneckener, Sergio Grimbs, Alexander Hillisch, Maren Osmers, Andreas H. Göller
Publikováno v:
Journal of Chemical Information and Modeling. 59:4893-4905
Oral administration of drug products is a strict requirement in many medical indications. Therefore, bioavailability prediction models are of high importance for prioritization of compound candidates in the drug discovery process. However, oral expos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de1ae1e6371dc92e1f47f4f034e6f598
https://doi.org/10.1021/acs.jcim.9b00460
https://doi.org/10.1021/acs.jcim.9b00460
Publikováno v:
Processes 10 (8): 1531 (2022-08)
Processes; Volume 10; Issue 8; Pages: 1531
Processes; Volume 10; Issue 8; Pages: 1531
For the purpose of the intensification of an industrial-scale gas-liquid process, the implementation in an alternative reactor concept is investigated at Hamburg University of Technology (TUHH) in cooperation with Ehrfeld Mikrotechnik GmbH. Existing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be184ea1943d4afe3b47748692ac5018
https://doi.org/10.3390/pr10081531
https://doi.org/10.3390/pr10081531
Publikováno v:
Bioinformatics
Bioinformatics 34, 494-501 (2018)
Bioinformatics 34, 494-501 (2018)
Motivation Mathematical models have become standard tools for the investigation of cellular processes and the unraveling of signal processing mechanisms. The parameters of these models are usually derived from the available data using optimization an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f8ab8cbc35875747094113ab5b5438
Publikováno v:
Interface focus. 5(6)
The prevalence of neutral mutations implies that biological systems typically have many more genotypes than phenotypes. But, can the way that genotypes are distributed over phenotypes determine evolutionary outcomes? Answering such questions is diffi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8905aa75e7e1473ff44a13644b33100
https://pubmed.ncbi.nlm.nih.gov/26640651
https://pubmed.ncbi.nlm.nih.gov/26640651
Publikováno v:
Proceedings. Biological sciences. 279(1734)
In evolution, the effects of a single deleterious mutation can sometimes be compensated for by a second mutation which recovers the original phenotype. Such epistatic interactions have implications for the structure of genome space - namely, that net
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0aa1249e4adc115b7f809eb24bb466
https://pubmed.ncbi.nlm.nih.gov/22158953
https://pubmed.ncbi.nlm.nih.gov/22158953
Publikováno v:
Proceedings of the Royal Society B: Biological Sciences; 5/ 7/2012, Vol. 279 Issue 1734, p1777-1783, 7p