Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Steffen Roßner"'
Autor:
Corinna Höfling, Luise Ulrich, Sina Burghardt, Philippa Donkersloot, Michael Opitz, Stefanie Geissler, Stephan Schilling, Holger Cynis, Dominik Michalski, Steffen Roßner
Publikováno v:
Cells, Vol 13, Iss 17, p 1412 (2024)
Glutaminyl cyclase (QC) and its isoenzyme (isoQC) catalyze the formation of N-terminal pyroglutamate (pGlu) from glutamine on a number of neuropeptides, peptide hormones and chemokines. Chemokines of the C-C ligand (CCL) motif family are known to con
Externí odkaz:
https://doaj.org/article/11689dccf9324a1ea32139ce64afeb8b
Autor:
Susan Barendrecht, An Schreurs, Stefanie Geissler, Victor Sabanov, Victoria Ilse, Vera Rieckmann, Rico Eichentopf, Anja Künemund, Benjamin Hietel, Sebastian Wussow, Katrin Hoffmann, Kerstin Körber-Ferl, Ravi Pandey, Gregory W. Carter, Hans-Ulrich Demuth, Max Holzer, Steffen Roßner, Stephan Schilling, Christoph Preuss, Detlef Balschun, Holger Cynis
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-23 (2023)
Abstract Background Hyperphosphorylation and intraneuronal aggregation of the microtubule-associated protein tau is a major pathological hallmark of Alzheimer’s disease (AD) brain. Of special interest is the effect of cerebral amyloid beta depositi
Externí odkaz:
https://doaj.org/article/a9c1be2cbfd647cb8dd039ae107ce4ee
Autor:
Corinna Höfling, Steffen Roßner, Bianca Flachmeyer, Martin Krueger, Wolfgang Härtig, Dominik Michalski
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 11893 (2023)
Along with initiatives to understand the pathophysiology of stroke in detail and to identify neuroprotective targets, cell-stabilizing elements have gained increasing attention. Although cell culture experiments have indicated that tricellulin, α-ca
Externí odkaz:
https://doaj.org/article/67c84c797ee34ca3842a0807906b3c87
Autor:
Benedikt Schwarze, Alexander Korn, Corinna Höfling, Ulrike Zeitschel, Martin Krueger, Steffen Roßner, Daniel Huster
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Fibril formation of amyloid β (Aβ) peptides is one of the key molecular events connected to Alzheimer’s disease. The pathway of formation and mechanism of action of Aβ aggregates in biological systems is still object of very active rese
Externí odkaz:
https://doaj.org/article/baa97eb7d29641b28269155211887f4e
Autor:
Kathrin Gnoth, Anke Piechotta, Martin Kleinschmidt, Sandra Konrath, Mathias Schenk, Nadine Taudte, Daniel Ramsbeck, Vera Rieckmann, Stefanie Geissler, Rico Eichentopf, Susan Barendrecht, Maike Hartlage-Rübsamen, Hans-Ulrich Demuth, Steffen Roßner, Holger Cynis, Jens-Ulrich Rahfeld, Stephan Schilling
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-20 (2020)
Abstract Background Amyloid β (Aβ)-directed immunotherapy has shown promising results in preclinical and early clinical Alzheimer’s disease (AD) trials, but successful translation to late clinics has failed so far. Compelling evidence suggests th
Externí odkaz:
https://doaj.org/article/2c961e761ce84b74a60f7925a3750699
Autor:
Alexandra Bluhm, Sarah Schrempel, Stephan Schilling, Stephan von Hörsten, Anja Schulze, Steffen Roßner, Maike Hartlage-Rübsamen
Publikováno v:
Biomolecules, Vol 12, Iss 7, p 1006 (2022)
The deposition of β-amyloid peptides and of α-synuclein proteins is a neuropathological hallmark in the brains of Alzheimer’s disease (AD) and Parkinson’s disease (PD) subjects, respectively. However, there is accumulative evidence that both pr
Externí odkaz:
https://doaj.org/article/2cf6a5bc4a9446cd8abe2fdaaaa8d090
Autor:
Victoria Ilse, Rebekka Scholz, Michael Wermann, Marcel Naumann, Martin S. Staege, Steffen Roßner, Holger Cynis
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8330 (2022)
The triggers for the development of multiple sclerosis (MS) have not been fully understood to date. One hypothesis proposes a viral etiology. Interestingly, viral proteins from human endogenous retroviruses (HERVs) may play a role in the pathogenesis
Externí odkaz:
https://doaj.org/article/8be835a470b24ec6aec7f7f733c1ad54
Autor:
Maike Hartlage-Rübsamen, Veronika Ratz, Ulrike Zeitschel, Lukas Finzel, Lisa Machner, Janett Köppen, Anja Schulze, Hans-Ulrich Demuth, Stephan von Hörsten, Corinna Höfling, Steffen Roßner
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-19 (2019)
Abstract Pathogenic variants of the huntingtin (HTT) protein and their aggregation have been investigated in great detail in brains of Huntington’s disease patients and HTT-transgenic animals. However, little is known about the physiological brain
Externí odkaz:
https://doaj.org/article/a1306f3f0a4543f58627dc1ea08af327
Publikováno v:
Biomolecules, Vol 12, Iss 5, p 694 (2022)
Neurodegenerative disorders including Parkinson’s disease (PD), Huntington’s disease (HD) and the most frequent, Alzheimer’s disease (AD), represent one of the most urgent medical needs worldwide. Despite a significantly developed understanding
Externí odkaz:
https://doaj.org/article/c73336f6e0cd4c6aa9d38bfaa2e305e0
Autor:
Claudia Berger, Henrike O. Heyne, Tina Heiland, Sebastian Dommel, Corinna Höfling, Esther Guiu-Jurado, Jana Lorenz, Steffen Roßner, Michael Dannemann, Janet Kelso, Peter Kovacs, Matthias Blüher, Nora Klöting
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100105- (2021)
The leptin receptor (Lepr) pathway is important for food intake regulation, energy expenditure, and body weight. Mutations in leptin and the Lepr have been shown to cause early-onset severe obesity in mice and humans. In studies with C57BL/6NCrl mice
Externí odkaz:
https://doaj.org/article/bac5f66a49d94390bd9f63b87d784bee