Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Steffen Renner"'
Autor:
Chaoyang Ye, Daniel J. Ho, Marilisa Neri, Chian Yang, Tripti Kulkarni, Ranjit Randhawa, Martin Henault, Nadezda Mostacci, Pierre Farmer, Steffen Renner, Robert Ihry, Leandra Mansur, Caroline Gubser Keller, Gregory McAllister, Marc Hild, Jeremy Jenkins, Ajamete Kaykas
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
RNA-seq is a powerful tool to investigate how drugs affect the transcriptome but library construction can be costly. Here the authors introduce DRUG-seq, an automated platform for high-throughput transcriptome profiling.
Externí odkaz:
https://doaj.org/article/7b7edf1cccfe4d95aaa258f27cffc83f
Autor:
Keene L. Abbott, Ahmed Ali, Dominick Casalena, Brian T. Do, Raphael Ferreira, Jaime H. Cheah, Christian K. Soule, Amy Deik, Tenzin Kunchok, Daniel R. Schmidt, Steffen Renner, Sophie E. Honeder, Michelle Wu, Sze Ham Chan, Tenzin Tseyang, Daniel Greaves, Peggy P. Hsu, Christopher W. Ng, Chelsea J. Zhang, Ali Farsidjani, Iva Monique T. Gramatikov, Nicholas J. Matheson, Caroline A. Lewis, Clary B. Clish, Matthew G. Rees, Jennifer A. Roth, Lesley Mathews Griner, Alexander Muir, Douglas S. Auld, Matthew G. Vander Heiden
SUMMARYA challenge for screening new candidate drugs to treat cancer is that efficacy in cell culture models is not always predictive of efficacy in patients. One limitation of standard cell culture is a reliance on non-physiological nutrient levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::121795f51a2d3bf410bf9d8120ac9c3b
https://doi.org/10.1101/2023.02.25.529972
https://doi.org/10.1101/2023.02.25.529972
Autor:
Emilia Neuwirt, Giovanni Magnani, Tamara Ćiković, Svenja Wöhrle, Larissa Fischer, Anna Kostina, Stephan Flemming, Nora J. Fischenich, Benedikt S. Saller, Oliver Gorka, Steffen Renner, Claudia Agarinis, Christian N. Parker, Andreas Boettcher, Christopher J. Farady, Rebecca Kesselring, Christopher Berlin, Rolf Backofen, Marta Rodriguez-Franco, Clemens Kreutz, Marco Prinz, Martina Tholen, Thomas Reinheckel, Thomas Ott, Christina J. Groß, Philipp J. Jost, Olaf Groß
Publikováno v:
Science Signaling. 16
Inflammasomes are intracellular protein complexes that promote an inflammatory host defense in response to pathogens and damaged or neoplastic tissues and are implicated in inflammatory disorders and therapeutic-induced toxicity. We investigated the
Autor:
Jingyao Li, Daniel J. Ho, Martin Henault, Chian Yang, Marilisa Neri, Robin Ge, Steffen Renner, Leandra Mansur, Alicia Lindeman, Brian Kelly, Tayfun Tumkaya, Xiaoling Ke, Gilberto Soler-Llavina, Gopi Shanker, Carsten Russ, Marc Hild, Caroline Gubser Keller, Jeremy L. Jenkins, Kathleen A. Worringer, Frederic D. Sigoillot, Robert J. Ihry
Publikováno v:
ACS chemical biology. 17(6)
Unbiased transcriptomic RNA-seq data has provided deep insights into biological processes. However, its impact in drug discovery has been narrow given high costs and low throughput. Proof-of-concept studies with Digital RNA with pertUrbation of Genes
Autor:
Emilia Neuwirt, Giovanni Magnani, Tamara Ćiković, Anna Kostina, Svenja Wöhrle, Stephan Flemming, Larissa Fischer, Nora J. Fischenich, Benedikt S. Saller, Oliver Gorka, Steffen Renner, Claudia Agarinis, Christian Parker, Andreas Boettcher, Christopher J. Farady, Rolf Backofen, Marta Rodriguez-Franco, Martina Tholen, Thomas Reinheckel, Thomas Ott, Christina J. Groß, Philipp J. Jost, Olaf Groß
Inflammasomes are intracellular protein complexes that control proteolytic maturation and secretion of inflammatory interleukin-1 (IL-1) family cytokines and are thus important in host defense. While some inflammasomes are activated simply by binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91918a639a74468417a76d5d58c4b680
https://doi.org/10.1101/2022.02.19.480941
https://doi.org/10.1101/2022.02.19.480941
Autor:
Kathleen A. Worringer, Robert J. Ihry, Marc Hild, Carsten Russ, Marilisa Neri, Leandra Mansur, Alicia Lindeman, Frederic Sigoillot, Chian Yang, Robin Ge, Jeremy L. Jenkins, Daniel J. Ho, Caroline Gubser Keller, Tayfun Tumkaya, Jingyao Li, Steffen Renner, Martin Henault
Unbiased transcriptomic RNA-seq data has provided deep insights about biological processes. However, its impact in drug discovery has been narrow given high costs and low throughput. Proof-of-concept studies with Digital RNA with pertUrbation of Gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4d7c984cbca815756ba3415d0008b95
https://doi.org/10.1101/2021.06.07.447456
https://doi.org/10.1101/2021.06.07.447456
Autor:
Karen Kapur, Ansgar Schuffenhauer, Eugen Lounkine, Christian Bergsdorf, Valerie Techer-Etienne, Andrea Marco Amati, Hanspeter Gubler, Edward James Oakeley, Sebastian Hoersch, Ludivine Flotte, Rochdi Bouhelal, Steffen Renner, Nicole Reymann, Pierre Farmer, Magdalena Koziczak-Holbro
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
Multiplexed gene-signature-based phenotypic assays are increasingly used for the identification and profiling of small molecule-tool compounds and drugs. Here we introduce a method (provided as R-package) for the quantification of the dose-response p
Autor:
Pierre Farmer, Ansgar Schuffenhauer, Nicole Reymann, Magdalena Koziczak-Holbro, Sebastian Hoersch, Edward James Oakeley, Rochdi Bouhelal, Eugen Lounkine, Hanspeter Gubler, Karen Kapur, Ludivine Flotte, Steffen Renner, Christian Bergsdorf, Andrea Marco Amati, Valerie Techer-Etienne
Multiplexed gene-signature-based phenotypic assays are increasingly used for the identification and profiling of small molecule-tool compounds and drugs. Here we introduce a method (provided as R-package) for the quantification of the dose-response p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1832d12c995827a300af25a542bf6ba7
https://doi.org/10.1101/799106
https://doi.org/10.1101/799106
Autor:
Gabi Schutzius, Michael Faller, Aimee Reynolds, Ralph Tiedt, Julia Klopp, Florian Fuchs, Laure C. Bouchez, Federico Tortelli, Nelly Leroy, Jonathan J. Turner, Guglielmo Roma, Simona Cotesta, Armin Beyerbach, Peter Drueckes, Shola M Richards, Debora Bonenfant, Heinrich Rueeger, Heinz Ruffner, Jutta Blank, Rémi Terranova, Peter Tarsa, Frederic Grandjean, Florian Nigsch, Sebastian Bergling, Natalie Dales, Alexandra Aebi, Paul W. Manley, Markus Schirle, Christian Kolter, Tewis Bouwmeester, Rene Hemmig, Sukhdeep Sahambi, Lori L. Jennings, Walter Carbone, Felix Lohmann, Alfred Zimmerlin, Jun Li, Susan Kirkland, Steffen Renner, Mathias Frederiksen, Vickie Driver, Amy Berwick, Florence Zink, Jason R. Thomas, Andrea Vaupel, Chris Dimitri, Vito Guagnano, Viktoria Gruber, Malvina Louis, Caroline Gubser Keller, Adrian Salathe
Publikováno v:
Nature chemical biology. 17(3)
Although most acute skin wounds heal rapidly, non-healing skin ulcers represent an increasing and substantial unmet medical need that urgently requires effective therapeutics. Keratinocytes resurface wounds to re-establish the epidermal barrier by tr
Autor:
Robert J. Ihry, Nadezda Mostacci, Gregory McAllister, Martin Henault, Caroline Gubser Keller, Jeremy L. Jenkins, Steffen Renner, Daniel J. Ho, Chaoyang Ye, Ajamete Kaykas, Marilisa Neri, Chian Yang, Leandra Mansur, Marc Hild, Tripti Kulkarni, Pierre Farmer, Ranjit Randhawa
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Nature Communications
Nature Communications
Here we report Digital RNA with pertUrbation of Genes (DRUG-seq), a high-throughput platform for drug discovery. Pharmaceutical discovery relies on high-throughput screening, yet current platforms have limited readouts. RNA-seq is a powerful tool to