Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Steffen Pabel"'
Autor:
Rebecca Schönmehl, Daniel H. Mendelsohn, Lina Winter, Steffen Pabel, Tanja Niedermair, Katja Evert, Wing-Hoi Cheung, Ronald Man Yeung Wong, Volker H. Schmitt, Karsten Keller, Friedrich Barsch, Alexander Dietl, Jan F. Gummert, René Schramm, Samuel Sossalla, Christoph Brochhausen
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7644 (2024)
Background: Mitochondria play a crucial role in adapting to fluctuating energy demands, particularly in various heart diseases. This study investigates mitochondrial morphology near intercalated discs in left ventricular (LV) heart tissues, comparing
Externí odkaz:
https://doaj.org/article/03b26e33f7474ec7b0672325fe2460dc
Autor:
Philipp Bengel, Nataliya Dybkova, Petros Tirilomis, Shakil Ahmad, Nico Hartmann, Belal A. Mohamed, Miriam Celine Krekeler, Wiebke Maurer, Steffen Pabel, Maximilian Trum, Julian Mustroph, Jan Gummert, Hendrik Milting, Stefan Wagner, Senka Ljubojevic-Holzer, Karl Toischer, Lars S. Maier, Gerd Hasenfuss, Katrin Streckfuss-Bömeke, Samuel Sossalla
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
In heart failure, increased CaMKII activity is decisively involved in arrhythmia formation. Here, the authors introduce the neuronal sodium channel NaV1.8 as a CaMKII downstream target as its specific knock-out reduces arrhythmias and improves surviv
Externí odkaz:
https://doaj.org/article/ba56cc69ae1140aebe506e2a3f9b30eb
Autor:
Maximilian Trum, Johannes Riechel, Simon Lebek, Steffen Pabel, Samuel T. Sossalla, Stephan Hirt, Michael Arzt, Lars S. Maier, Stefan Wagner
Publikováno v:
ESC Heart Failure, Vol 7, Iss 6, Pp 4429-4437 (2020)
Abstract Aims Recent clinical trials have proven gliflozins to be cardioprotective in diabetic and non‐diabetic patients. However, the underlying mechanisms are incompletely understood. A potential inhibition of cardiac Na+/H+ exchanger 1 (NHE1) ha
Externí odkaz:
https://doaj.org/article/e817028f741049389f92939fa5c6a33a
Autor:
Julian Mustroph, Marzena Drzymalski, Maria Baier, Steffen Pabel, Alexander Biedermann, Bernadette Memmel, Melanie Durczok, Stefan Neef, Can Martin Sag, Bernhard Floerchinger, Leopold Rupprecht, Christof Schmid, York Zausig, Guillaume Bégis, Veronique Briand, Marie‐Laure Ozoux, Dorothee Tamarelle, Veronique Ballet, Philip Janiak, Philippe Beauverger, Lars S. Maier, Stefan Wagner
Publikováno v:
ESC Heart Failure, Vol 7, Iss 5, Pp 2871-2883 (2020)
Abstract Aims Excessive activation of Ca/calmodulin‐dependent kinase II (CaMKII) is of critical importance in heart failure (HF) and atrial fibrillation. Unfortunately, lack of selectivity, specificity, and bioavailability have slowed down developm
Externí odkaz:
https://doaj.org/article/57dc9a1530ee492497a97ff40956bd3e
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Heart failure with preserved ejection fraction (HFpEF) is an unsolved and growing concern in cardiovascular medicine. While no treatment options that improve prognosis in HFpEF patients has been established so far, SGLT2 inhibitors (SGLT2i) are curre
Externí odkaz:
https://doaj.org/article/31eba08da8b04904b15c4c805768ab11
Autor:
M. M. Towhidul Islam, Daniel Tarnowski, Min Zhang, Maximilian Trum, Simon Lebek, Julian Mustroph, Henriette Daniel, Johanna Moellencamp, Steffen Pabel, Samuel Sossalla, Ali El‐Armouche, Viacheslav O. Nikolaev, Ajay M. Shah, Philip Eaton, Lars S. Maier, Can Martin Sag, Stefan Wagner
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 19 (2021)
Background PKARIα (protein kinase A type I‐α regulatory subunit) is redox‐active independent of its physiologic agonist cAMP. However, it is unknown whether this alternative mechanism of PKARIα activation may be of relevance to cardiac excitat
Externí odkaz:
https://doaj.org/article/c41f9e0efc2e43b39a82934e6734a4e4
Autor:
Daniel H. Mendelsohn, Katja Schnabel, Andreas Mamilos, Samuel Sossalla, Steffen Pabel, Georg Daniel Duerr, Karsten Keller, Volker H. Schmitt, Friedrich Barsch, Nike Walter, Ronald Man Yeung Wong, Thaqif El Khassawna, Tanja Niedermair, Volker Alt, Markus Rupp, Christoph Brochhausen
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 4571 (2022)
Mitochondria play a crucial role in cell physiology and pathophysiology. In this context, mitochondrial dynamics and, subsequently, mitochondrial ultrastructure have increasingly become hot topics in modern research, with a focus on mitochondrial fis
Externí odkaz:
https://doaj.org/article/bd46b2a1b1574e1d9466c88730b94820
Autor:
Thomas, Körtl, Thea, Stehle, Dominic, Riedl, Johanna, Trausel, Sabine, Rebs, Steffen, Pabel, Michael, Paulus, Andreas, Holzamer, Nassir, Marrouche, Lars S, Maier, Christian, Sohns, Katrin, Streckfuss-Bömeke, Samuel, Sossalla
Publikováno v:
JACC: Clinical Electrophysiology. 8:1357-1366
Atrial fibrillation (AF) can either be a consequence or an underlying mechanism of left ventricular systolic dysfunction. Patients included in the CASTLE-AF (Catheter Ablation vs. Standard Conventional Treatment in Patients With LV Dysfunction and AF
Autor:
Fitzwilliam Seibertz, Henry Sutanto, Rebekka Dülk, Julius Ryan D. Pronto, Robin Springer, Markus Rapedius, Aiste Liutkute, Melanie Ritter, Philipp Jung, Lea Stelzer, Luisa M. Hüsgen, Marie Klopp, Tony Rubio, Funsho E. Fakuade, Fleur E. Mason, Nico Hartmann, Steffen Pabel, Katrin Streckfuss-Bömeke, Lukas Cyganek, Samuel Sossalla, Jordi Heijman, Niels Voigt
Publikováno v:
Basic Research in Cardiology, 118(1):14. Springer
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are increasingly used for personalised medicine and preclinical cardiotoxicity testing. Reports on hiPSC-CM commonly describe heterogenous functional readouts and underdeveloped o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::213c88ce07821e471c59148365138869
https://cris.maastrichtuniversity.nl/en/publications/c8a37e38-5352-4a54-93dd-2077ae9f4eab
https://cris.maastrichtuniversity.nl/en/publications/c8a37e38-5352-4a54-93dd-2077ae9f4eab
Autor:
Steffen Pabel, Maria Knierim, Thea Stehle, Felix Alebrand, Michael Paulus, Marcel Sieme, Melissa Herwig, Friedrich Barsch, Thomas Körtl, Arnold Pöppl, Brisca Wenner, Senka Ljubojevic-Holzer, Cristina E. Molina, Nataliya Dybkova, Daniele Camboni, Thomas H. Fischer, Simon Sedej, Daniel Scherr, Christof Schmid, Christoph Brochhausen, Gerd Hasenfuß, Lars S. Maier, Nazha Hamdani, Katrin Streckfuss-Bömeke, Samuel Sossalla
Publikováno v:
Circulation Research. 130:994-1010
Rationale: Atrial fibrillation (AF) and heart failure often coexist, but their interaction is poorly understood. Clinical data indicate that the arrhythmic component of AF may contribute to left ventricular (LV) dysfunction. Objective: This study inv