Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Steffen M. Bernard"'
Autor:
Tanya R. McKitrick, Steffen M. Bernard, Alexander J. Noll, Bernard C. Collins, Christoffer K. Goth, Alyssa M. McQuillan, Jamie Heimburg-Molinaro, Brantley R. Herrin, Ian A. Wilson, Max D. Cooper, Richard D. Cummings
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
McKitrick et al engineer and characterize a novel lamprey antibody that recognizes terminal sulfated galactose epitopes on mammalian glycoproteins. This provides a new tool for the exploration of glycoprotein sulfation in mammalian cells, which could
Externí odkaz:
https://doaj.org/article/fc44f226d9cf4dce8756ecf26052d69b
Autor:
Brantley R. Herrin, Alyssa M McQuillan, Max D. Cooper, Ian A. Wilson, Richard D. Cummings, Tanya R. McKitrick, Alexander J. Noll, Jamie Heimburg-Molinaro, Christoffer K. Goth, Steffen M. Bernard, B.C. Collins
Publikováno v:
McKitrick, T R, Bernard, S M, Noll, A J, Collins, B C, Goth, C K, McQuillan, A M, Heimburg-Molinaro, J, Herrin, B R, Wilson, I A, Cooper, M D & Cummings, R D 2021, ' Novel lamprey antibody recognizes terminal sulfated galactose epitopes on mammalian glycoproteins ', Communications Biology, vol. 4, no. 1, 674 . https://doi.org/10.1038/s42003-021-02199-7
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology
The terminal galactose residues of N- and O-glycans in animal glycoproteins are often sialylated and/or fucosylated, but sulfation, such as 3-O-sulfated galactose (3-O-SGal), represents an additional, but poorly understood modification. To this end,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d3428a69bbe1ad8ceb25911955bf383
https://curis.ku.dk/ws/files/281709150/Novel_lamprey_antibody_recognizes_terminal.pdf
https://curis.ku.dk/ws/files/281709150/Novel_lamprey_antibody_recognizes_terminal.pdf
Autor:
Devin Sok, Sven Kratochvil, Jon M. Steichen, Laura Toy, Nicole Phelps, Eleonora Melzi, Jordan R. Willis, Oleksandr Kalyuzhniy, Ying-Cing Lin, Amanda M Robinson, Shane Crotty, Facundo D. Batista, Steffen M. Bernard, Erik Georgeson, Simone Pecetta, Xiaozhen Hu, Sebastian Raemisch, William R. Schief, Jonathan L. Torres, Bryan Briney, Jeffrey C. Umotoy, Daniel W. Kulp, Alessia Liguori, Gabriel Ozorowski, Colin Havenar-Daughton, Yumiko Adachi, Dennis R. Burton, Ian A. Wilson, Elise Landais, Andrew B. Ward, Michael Kubitz
Publikováno v:
Science
Science, 366(6470):eaax4380. American Association for the Advancement of Science
Science, 366(6470):eaax4380. American Association for the Advancement of Science
Engineering better bnAbs A highly effective HIV vaccine has been the goal of vaccinologists for nearly 35 years. A successful vaccine would need to induce broadly neutralizing antibodies (bnAbs) that are capable of neutralizing multiple HIV strains (
Autor:
Merika Treants Koday, Christopher D. Bahl, Aaron Chevalier, Lu Zhang, Lauren Carter, James T. Fuller, Deborah H. Fuller, Gabriel J. Rocklin, Inna Goreshnik, Min Dong, Kwok-Ho Lam, Shin-Ichiro Miyashita, David Baker, Steffen M. Bernard, Tom Colvin, Rongsheng Jin, Cassie M. Bryan, Guorui Yao, Xuhui Huang, Renan Vergara, Ian A. Wilson, Derrick R. Hicks, Lance Stewart, Cody M. Jenkins, D. Alejandro Fernández-Velasco, Daniel-Adriano Silva, Patience Murapa, Alan J. Bohn
Publikováno v:
Nature, vol 550, iss 7674
De novo protein design holds promise for creating small stable proteins with shapes customized to bind therapeutic targets. We describe a massively parallel approach for designing, manufacturing and screening mini-protein binders, integrating large-s
Autor:
Deborah H. Fuller, Rashmi Ravichandran, Peter Lee, Natalie K. Garcia, Kathryn A. Hooper, David Baker, Jorgen Nelson, David La, Ian A. Wilson, Caitlin E. Anderson, Andrew B. Ward, Eva-Maria Strauch, Steffen M. Bernard, Alan J. Bohn, William Sheffler, Jesse D. Bloom, Carly A. Holstein, Kelly K. Lee, Travis Nieusma, Paul Yager
Publikováno v:
Nature biotechnology
Many viral surface glycoproteins and cell surface receptors are homo-oligomers1-4, and hence can potentially be targeted by geometrically matched homo-oligomers that engage all subunits simultaneously to attain high avidity and/or lock subunits toget
Autor:
Peter Wipf, Steffen M. Bernard, Marissa M. Bivins, Sarang Kulkarni, David H. Sherman, Meredith A. Skiba, Janet L. Smith, John R. Schultz, William D. Fiers, Qingyun Dan, Courtney C. Aldrich, William H. Gerwick
Publikováno v:
ACS chemical biology, vol 13, iss 12
Modular type I polyketide synthases (PKSs) produce some of the most chemically complex metabolites in nature through a series of multienzyme modules. Each module contains a variety of catalytic domains to selectively tailor the growing molecule. PKS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3587cf5749e1f6c63c102647d9c9c31c
https://europepmc.org/articles/PMC6470024/
https://europepmc.org/articles/PMC6470024/
Autor:
Aparna Sapra, Erik R. P. Zuiderweg, Steffen M. Bernard, Janet L. Smith, Bruce A. Palfey, Frederick Stull
Publikováno v:
Biochemistry. 55:3261-3269
Many microorganisms use flavin-dependent thymidylate synthase (FDTS) to synthesize the essential nucleotide 2'-deoxythymidine 5'-monophosphate (dTMP) from 2'-deoxyuridine 5'-monophosphate (dUMP), 5,10-methylenetetrahydrofolate (CH2THF), and NADPH. FD
Autor:
Jamie R. Konwerski, Janet L. Smith, Steffen M. Bernard, Yojiro Anzai, Shengying Li, David H. Sherman, Sung Ryeol Park, Ashootosh Tripathi, David L. Akey, Fumio Kato
Publikováno v:
ACS Chemical Biology. 10:1340-1351
Sugar moieties in natural products are frequently modified by O-methylation. In the biosynthesis of the macrolide antibiotic mycinamicin, methylation of a 6′-deoxyallose substituent occurs in a stepwise manner first at the 2′- and then the 3′-h
Autor:
Mandy Jongeneelen, Maria P. Limberis, M. van der Neut Kolfschoten, A. van Eijgen, Ryan M. B. Hoffman, Nick S. Laursen, David Zuijdgeest, Steffen M. Bernard, Leo L.M. Poon, Ian A. Wilson, Jesper Pallesen, Hannah L. Turner, J. Luo, Sven Blokland, H. van Diepen, R. Straetemans, G. Obmolova, J.A. Kolkman, Jan Vermond, James M. Wilson, Travis Nieusma, Anna Tretiakova, Robert H. E. Friesen, Xueyong Zhu, Chan Tang, Ronald Vogels, Boerries Brandenburg, Andrew B. Ward
Publikováno v:
Science (New York, N.Y.). 362(6414)
Durable influenza protection Vaccines are indispensable for the control and prevention of influenza, but there are several challenges to efficacy. Some individuals respond poorly to vaccination, and virus variation makes targeting optimal antigens di
Autor:
Janet L. Smith, William D. Fiers, Robert A. Fecik, Yang Li, Steffen M. Bernard, Courtney C. Aldrich
Publikováno v:
ACS Chemical Biology
Among natural product families, polyketides have shown the most promise for combinatorial biosynthesis of natural product-like libraries. Though recent research in the area has provided many mechanistic revelations, a basic-level understanding of kin