L-Kynurenine participates in cancer immune evasion by downregulating hypoxic signaling in T lymphocytes

Autor: Stephanie Schlichtner, Inna M. Yasinska, Elena Klenova, Maryam Abooali, Gurprit S. Lall, Steffen M. Berger, Sabrina Ruggiero, Dietmar Cholewa, Milan Milošević, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev

Publikováno v: OncoImmunology, Vol 12, Iss 1 (2023)

ABSTRACTMalignant tumors often escape anticancer immune surveillance by suppressing the cytotoxic functions of T lymphocytes. While many of these immune evasion networks include checkpoint proteins, small molecular weight compounds, such as the amino

Externí odkaz: https://doaj.org/article/af8e958bbeec46739a4b45819fd24cbb

Expression of the Immune Checkpoint Protein VISTA Is Differentially Regulated by the TGF-β1 – Smad3 Signaling Pathway in Rapidly Proliferating Human Cells and T Lymphocytes

Autor: Stephanie Schlichtner, Inna M. Yasinska, Sabrina Ruggiero, Steffen M. Berger, Nijas Aliu, Mateja Prunk, Janko Kos, N. Helge Meyer, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev

Publikováno v: Frontiers in Medicine, Vol 9 (2022)

Immune checkpoint proteins play crucial roles in human embryonic development but are also used by cancer cells to escape immune surveillance. These proteins and biochemical pathways associated with them form a complex machinery capable of blocking th

Externí odkaz: https://doaj.org/article/df9cbb22cd0c4b25850127b6e31a3396

Ligand-Receptor Interactions of Galectin-9 and VISTA Suppress Human T Lymphocyte Cytotoxic Activity

Autor: Inna M. Yasinska, N. Helge Meyer, Stephanie Schlichtner, Rohanah Hussain, Giuliano Siligardi, Maxwell Casely-Hayford, Walter Fiedler, Jasmin Wellbrock, Cloe Desmet, Luigi Calzolai, Luca Varani, Steffen M. Berger, Ulrike Raap, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Acute myeloid leukemia (AML), a blood/bone marrow cancer, is a severe and often fatal malignancy. AML cells are capable of impairing the anti-cancer activities of cytotoxic lymphoid cells. This includes the inactivation of natural killer (NK) cells a

Externí odkaz: https://doaj.org/article/fde3b7a88f6a40a58578f302b9d89082

Chromosomal Heterogeneity of the G-401 Rhabdoid Tumor Cell Line: Unusual Partial 7p Trisomy

Autor: Elizaveta Fasler-Kan, Nijas Aliu, Frank-Martin Haecker, Natalia Maltsev, Sabrina Ruggiero, Dietmar Cholewa, Andreas Bartenstein, Milan Milošević, Steffen M. Berger

Publikováno v: Frontiers in Medicine, Vol 6 (2019)

Rhabdoid tumor is a very aggressive and hardly curable pediatric malignancy. It commonly starts in the kidneys but also can occur in the brain, liver, and other organs. The treatment of this tumor usually involves a combination of surgery, radiation,

Externí odkaz: https://doaj.org/article/40b7232bc3ef453b92198f5819937236

T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint proteins

Autor: Stephanie Schlichtner, Inna M Yasinska, Gurprit S Lall, Steffen M Berger, Sabrina Ruggiero, Dietmar Cholewa, Nijas Aliu, Bernhard F Gibbs, Elizaveta Fasler-Kan, Vadim V Sumbayev

Publikováno v: Schlichtner, Stephanie; Yasinska, Inna M; Lall, Gurprit S; Berger, Steffen M; Ruggiero, Sabrina; Cholewa, Dietmar; Aliu, Nijas; Gibbs, Bernhard F; Fasler-Kan, Elizaveta; Sumbayev, Vadim V (2023). T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint proteins. Journal for immunotherapy of cancer, 11(1) BioMed Central 10.1136/jitc-2022-005714

BackgroundGalectin-9 is a member of the family of lectin proteins and crucially regulates human immune responses, particularly because of its ability to suppress the anticancer activities of T lymphocytes and natural killer cells. Recent evidence dem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff44acfe45543995042b9ce01edc1d6
https://pubmed.ncbi.nlm.nih.gov/36599470