Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Steffen Hvidt"'
Autor:
Harriet Dige-Petersen, Steffen Hvidt
Publikováno v:
Acta Medica Scandinavica. 181:219-222
Publikováno v:
Acta Medica Scandinavica. 207:291-295
The pharmacokinetics of digoxin was studied in 11 subjects before and during quinidine treatment. Renal clearances of digoxin and creatinine were calculated from plasma concentrations and urinary excretions of digoxin and creatinine in subjects on lo
Autor:
Knud Erik Pedersen, G. Sanchez, Karen Kjær, Steffen Hvidt, N. H. Berndtz, C. Midtskov, O. Koldkjær
Publikováno v:
Acta Medica Scandinavica. 213:357-362
Plasma digoxin measurements have proved unserviceable as a means of differentiating between toxic and non-toxic patients. In order to assess the value of a biological effect of digoxin in this discrimination, intraerythrocytic sodium and potassium co
Publikováno v:
Acta Medica Scandinavica. 172:567-571
Autor:
Folmer Nielsen-Kudsk, Steffen Hvidt, Niels Anders Klitgaard, Knud Erik Pedersen, Karen Kjær, Anton Dorph-Pedersen
Publikováno v:
Clinical Pharmacology and Therapeutics. 32:562-565
Verapamil has been shown to reduce total-body digoxin clearance by 35% due to impairments of both renal and extrarenal clearances. Our study was undertaken to evaluate the influence of the related calcium antagonist nifedipine on single-dose digoxin
Autor:
Steffen Hvidt, Niels Anders Klitgaard, Anton Dorph-Pedersen, Folmer Nielsen-Kudsk, Knud Erik Pedersen
Publikováno v:
Clinical Pharmacology and Therapeutics. 30:311-316
To explore a possible interaction between digoxin and verapamil, a single-dose kinetic study of digoxin was performed and then repeated after 10 days of verapamil treatment in eight healthy subjects. Verapamil diminished the apparent central distribu
Autor:
Steffen Hvidt, Niels Anders Klitgaard, K K Pedersen, Knud Erik Pedersen, Anton Dorph-Pedersen
Publikováno v:
European journal of clinical pharmacology. 22(2)
Single-dose investigations in healthy subjects have demonstrated substantial impairment of renal and extrarenal clearance of digoxin during coadministration of verapamil. A longitudinal study has been performed to assess the changes in digoxin dispos
Publikováno v:
Acta medica Scandinavica. 218(2)
In order to explore the digoxin-quinine interaction, digoxin steady state pharmacokinetics was studied before and during quinine coadministration in seven healthy subjects. Quinine (250 mg/day) increased mean plasma digoxin concentration from 0.64 +/
Publikováno v:
Clinical pharmacology and therapeutics. 34(3)
Plasma digoxin concentration and renal digoxin clearance were determined during 2 hr of normal physical activity and during 2 hr of complete immobilization in eight healthy subjects on steady-state digoxin dosing. Mean plasma digoxin concentration ro
Autor:
Knud Erik Pedersen, N. H. Berndtz, C. Midtskov, Steffen Hvidt, Karen Kjær, G. Sanche, O. Koldkjær
Publikováno v:
Acta medica Scandinavica. 211(5)
To assess the cellular effects of digoxin, intraerythrocytic sodium and potassium concentrations were measured in 17 patients during the early phase of digitalization, in 45 patients on long-term therapy and in 64 non-digitalized control patients. Ac