Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Steffen Durinck"'
Autor:
Kamakoti P. Bhat, Jinchu Vijay, Caroline K. Vilas, Jyoti Asundi, Jun Zou, Ted Lau, Xiaoyu Cai, Musaddeque Ahmed, Michal Kabza, Julie Weng, Jean-Philippe Fortin, Aaron Lun, Steffen Durinck, Marc Hafner, Michael R. Costa, Xin Ye
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114345- (2024)
Summary: Ferroptosis is an iron-dependent cell death mechanism characterized by the accumulation of toxic lipid peroxides and cell membrane rupture. GPX4 (glutathione peroxidase 4) prevents ferroptosis by reducing these lipid peroxides into lipid alc
Externí odkaz:
https://doaj.org/article/132ddd191a8d4ca78ef8a173dc07ec78
Autor:
Honglin Chen, Steffen Durinck, Hetal Patel, Oded Foreman, Kathryn Mesh, Jeffrey Eastham, Roger Caothien, Robert J. Newman, Merone Roose-Girma, Spyros Darmanis, Soren Warming, Annalisa Lattanzi, Yuxin Liang, Benjamin Haley
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 431-449 (2022)
With the aim of expediting drug target discovery and validation for respiratory diseases, we developed an optimized method for in situ somatic gene disruption in murine lung epithelial cells via AAV6-mediated CRISPR-Cas9 delivery. Efficient gene edit
Externí odkaz:
https://doaj.org/article/113e78dbbb674feba29efc5e54161173
Autor:
Kangsan Kim, Qinbo Zhou, Alana Christie, Christina Stevens, Yuanqing Ma, Oreoluwa Onabolu, Suneetha Chintalapati, Tiffani Mckenzie, Vanina Toffessi Tcheuyap, Layton Woolford, He Zhang, Nirmish Singla, Pravat Kumar Parida, Mauricio Marquez-Palencia, Ivan Pedrosa, Vitaly Margulis, Arthur Sagalowsky, Zhiqun Xie, Tao Wang, Steffen Durinck, Zora Modrusan, Somasekar Seshagiri, Payal Kapur, James Brugarolas, Srinivas Malladi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Tumour thrombi (TT) are intravascular extensions of renal cell carcinomas (RCC) which often lead to distant metastases. Here the authors examine the determinants of vascular invasion and metastasis in a unique cohort of RCC patients with TT using mul
Externí odkaz:
https://doaj.org/article/3266527d43244260bdb0306af8f05a4d
Integrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate
Autor:
Akhilesh Pandey, Eric W. Stawiski, Steffen Durinck, Harsha Gowda, Leonard D. Goldstein, Mustafa A. Barbhuiya, Markus S. Schröder, Sreelakshmi K. Sreenivasamurthy, Sun-Whe Kim, Sameer Phalke, Kushal Suryamohan, Kayla Lee, Papia Chakraborty, Vasumathi Kode, Xiaoshan Shi, Aditi Chatterjee, Keshava Datta, Aafaque A. Khan, Tejaswini Subbannayya, Jing Wang, Subhra Chaudhuri, Sanjiv Gupta, Braj Raj Shrivastav, Bijay S. Jaiswal, Satish S. Poojary, Shushruta Bhunia, Patricia Garcia, Carolina Bizama, Lorena Rosa, Wooil Kwon, Hongbeom Kim, Youngmin Han, Thakur Deen Yadav, Vedam L. Ramprasad, Amitabha Chaudhuri, Zora Modrusan, Juan Carlos Roa, Pramod Kumar Tiwari, Jin-Young Jang, Somasekar Seshagiri
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Gallbladder cancer incidence shows characteristic geographic patterns. Here the authors perform a genomic analysis of gallbladder cancers in patients from countries with high incidence (South Korea, India and Chile) and identify ELF3 and other signif
Externí odkaz:
https://doaj.org/article/4947118a87984a6abb9c9a6e884df1b9
Autor:
Wenlin Yuan, Leonard D. Goldstein, Steffen Durinck, Ying-Jiun Chen, Thong T. Nguyen, Noelyn M. Kljavin, Ethan S. Sokol, Eric W. Stawiski, Benjamin Haley, James Ziai, Zora Modrusan, Somasekar Seshagiri
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-11 (2019)
Abstract Background PIK3CA mutations are frequent in human breast cancer. Pik3caH1047R mutant expression in mouse mammary gland promotes tumorigenesis. TP53 mutations co-occur with PIK3CA mutations in human breast cancers. We previously generated a c
Externí odkaz:
https://doaj.org/article/bac8665eabf64d8bb2b775dde6b82c72
Autor:
Saurabh Belsare, Michal Levy-Sakin, Yulia Mostovoy, Steffen Durinck, Subhra Chaudhuri, Ming Xiao, Andrew S. Peterson, Pui-Yan Kwok, Somasekar Seshagiri, Jeffrey D. Wall
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-14 (2019)
Abstract Background Data from the 1000 Genomes project is quite often used as a reference for human genomic analysis. However, its accuracy needs to be assessed to understand the quality of predictions made using this reference. We present here an as
Externí odkaz:
https://doaj.org/article/9abbe3b5ce5e42f0b6b7cf90456ce02d
Autor:
Kate Senger, Wenlin Yuan, Meredith Sagolla, Jonas Doerr, Brad Bolon, James Ziai, Kai‐Hui Sun, Soren Warming, Merone Roose‐Girma, Na Zhang, Lucinda Tam, Robert J. Newman, Subhra Chaudhuri, Aju Antony, Leonard D. Goldstein, Steffen Durinck, Bijay S. Jaiswal, Daniel Lafkas, Zora Modrusan, Somasekar Seshagiri
Publikováno v:
Advanced Genetics, Vol 2, Iss 1, Pp n/a-n/a (2021)
Abstract ERBB3 is a pseudokinase domain‐containing member of the ERBB family of receptor tyrosine kinases (RTKs). Following ligand binding, ERBB receptors homo‐ or hetero‐dimerize, leading to a head‐to‐tail arrangement of the intracellular
Externí odkaz:
https://doaj.org/article/e07cd0add97d47c6835d733394de07a7
Autor:
Derek K. Smith, Lance Kates, Steffen Durinck, Nisha Patel, Eric W. Stawiski, Noelyn Kljavin, Oded Foreman, Bence Sipos, Mark J. Solloway, Bernard B. Allan, Andrew S. Peterson
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 5, Pp 100058- (2020)
Summary: The cellular origin of sporadic pancreatic neuroendocrine tumors (PNETs) is obscure. Hormone expression suggests that these tumors arise from glucagon-producing alpha cells or insulin-producing β cells, but instability in hormone expression
Externí odkaz:
https://doaj.org/article/1c910c653f594e98a5df4c10a69d5fe9
Autor:
Elizabeth A Germino, Joseph P Miller, Lauri Diehl, Carter J Swanson, Steffen Durinck, Zora Modrusan, Jeffrey H Miner, Andrey S Shaw
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194998 (2018)
Given the frequency with which MAP kinase signaling is dysregulated in cancer, much effort has been focused on inhibiting RAS signaling for therapeutic benefit. KSR1, a pseudokinase that interacts with RAF, is a potential target; it was originally cl
Externí odkaz:
https://doaj.org/article/e95cebb71d8944dd9688b9c793cac23d
Autor:
Morito Kurata, Emiily Pope, Jingmin Shu, Wenlin Yuan, Wendy Hudson, Mark Sokolowski, Setareh Bagherzadeh, Zora Modrusan, Eric Stawiski, Steffen Durinck, Sekar Seshigiri, Aaron Sarver, Nuri Temiz, David Largaespada
Publikováno v:
Cancer Research. 83:P3-08
Human breast cancer (BRCA) shows tremendous genomic, gene expression, clinical, and phenotypic heterogeneity. Known driver gene alterations can only explain a portion of this heterogeneity, some of which likely arise from variation in the target cell