Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Steffen C, Hinz"'
Autor:
Adrian Elter, Tina Bock, Dieter Spiehl, Giulio Russo, Steffen C. Hinz, Sebastian Bitsch, Eva Baum, Markus Langhans, Tobias Meckel, Edgar Dörsam, Harald Kolmar, Gerhard Schwall
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Since the pandemic outbreak of Covid-19 in December 2019, several lateral flow assay (LFA) devices were developed to enable the constant monitoring of regional and global infection processes. Additionally, innumerable lateral flow test devic
Externí odkaz:
https://doaj.org/article/46cba929f3f3461aa0a629fdd305a1ef
Autor:
Steffen C. Hinz, Adrian Elter, Oliver Rammo, Achim Schwämmle, Ataurehman Ali, Stefan Zielonka, Thomas Herget, Harald Kolmar
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Affinity chromatography provides an excellent platform for protein purification, which is a key step in the large scale downstream processing of therapeutic monoclonal antibodies (Mabs). Protein A chromatography constitutes the gold standard for Mab
Externí odkaz:
https://doaj.org/article/d9f77b27f59a460fa48f4fde4750675b
Autor:
Lukas Pekar, Michael Busch, Bernhard Valldorf, Steffen C. Hinz, Lars Toleikis, Simon Krah, Stefan Zielonka
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Here, we report the characterization of a VHH-derived IgG-like bi- and trispecific antibody platform that essentially relies on the replacement of the VH and VL regions of a conventional antibody by two independently functioning VHH domains. Conseque
Externí odkaz:
https://doaj.org/article/8401a02b7d7d4bcf96189b469880f51b
Autor:
Jan P. Bogen, Steffen C. Hinz, Julius Grzeschik, Aileen Ebenig, Simon Krah, Stefan Zielonka, Harald Kolmar
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Shedding of membrane-bound cell surface proteins, where the extracellular domain is released and found in the circulation is a common phenomenon. A prominent example is CEACAM5 (CEA, CD66e), where the shed domain plays a pivotal role in tumor progres
Externí odkaz:
https://doaj.org/article/ba9e1d5ff49340b0a93de1a3cf3e2c24
Autor:
Bernhard Valldorf, Steffen C. Hinz, Lukas Pekar, Michael Hust, Simon Krah, Achim Doerner, Janina Klemm, Stefan Zielonka, Laura Mohr, Giulio Russo
Publikováno v:
Biological Chemistry. 403:455-477
Antibody display technologies enable the successful isolation of antigen-specific antibodies with therapeutic potential. The key feature that facilitates the selection of an antibody with prescribed properties is the coupling of the protein variant t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac81381ccbce27897abd82a9eceb78b3
https://doi.org/10.1515/hsz-2020-0377
https://doi.org/10.1515/hsz-2020-0377
Autor:
Claudia Oliviero, Steffen C. Hinz, Jan P. Bogen, Henri Kornmann, Björn Hock, Harald Kolmar, Gerrit Hagens
Publikováno v:
Biotechnology progress. 38(4)
In recent years, targeted gene integration (TI) has been introduced as a strategy for the generation of recombinant mammalian cell lines for the production of biotherapeutics. Besides reducing the immense heterogeneity within a pool of recombinant tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac10c217b65a93648bfa014944fd33b
https://pubmed.ncbi.nlm.nih.gov/35396920
https://pubmed.ncbi.nlm.nih.gov/35396920
Autor:
Adrian Elter, Tina Bock, Dieter Spiehl, Giulio Russo, Steffen C. Hinz, Sebastian Bitsch, Eva Baum, Markus Langhans, Tobias Meckel, Edgar Dörsam, Harald Kolmar, Gerhard Schwall
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Since the pandemic outbreak of Covid-19 in December 2019, several lateral flow assay (LFA) devices were developed to enable the constant monitoring of regional and global infection processes. Additionally, innumerable lateral flow test devices are fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::363c27bc28c47650362c8669d3a0f65d
https://pubmed.ncbi.nlm.nih.gov/33846482
https://pubmed.ncbi.nlm.nih.gov/33846482
Autor:
Adrian Elter, Steffen C. Hinz, David Fiebig, Harald Kolmar, Jan P. Bogen, Björn Hock, Arturo Macarrón Palacios, Julius Grzeschik
Publikováno v:
Biotechnology journal. 16(3)
Generation of high-affinity monoclonal antibodies by immunization of chickens is a valuable strategy, particularly for obtaining antibodies directed against epitopes that are conserved in mammals. A generic procedure is established for the humanizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b676a768785895d3f1e8dd913f2635e
https://pubmed.ncbi.nlm.nih.gov/33078896
https://pubmed.ncbi.nlm.nih.gov/33078896
Autor:
Bernhard Valldorf, Simon Krah, Michael Busch, Lukas Pekar, Stefan Zielonka, Lars Toleikis, Steffen C. Hinz
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Here, we report the characterization of a VHH-derived IgG-like bi- and trispecific antibody platform that essentially relies on the replacement of the VH and VL regions of a conventional antibody by two independently functioning VHH domains. Conseque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c030f7dbebf25cf895120841d07124b3
https://doi.org/10.1080/19420862.2020.1812210
https://doi.org/10.1080/19420862.2020.1812210
Autor:
Doreen Könning, Martin Empting, Julius Grzeschik, Steffen C. Hinz, Stefan Zielonka, Harald Kolmar, Simon Krah
Publikováno v:
BIOspektrum. 24:142-145
The adaptive immune system of sharks comprises a very interesting antibody isotype named immunoglobulin new antigen receptor (IgNAR). In contrast to classical antibodies, the antigen binding site of the heavy chain only immunoglobulin is formed by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::095e64103ac295ffe97fbed351b48bac
https://doi.org/10.1007/s12268-018-0902-0
https://doi.org/10.1007/s12268-018-0902-0