Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Steffen Bugge"'
Autor:
Voin Petrovic, Camilla Olaisen, Animesh Sharma, Anala Nepal, Steffen Bugge, Eirik Sundby, Bård Helge Hoff, Geir Slupphaug, Marit Otterlei
Publikováno v:
Data in Brief, Vol 12, Iss C, Pp 18-21 (2017)
Cell extracts from A549, H460, and U2OS human cancer cell lines treated with cisplatin and docetaxel were analyzed by mass spectrometry (MS) proteomic analysis. The extracts were enriched for cellular signaling proteins using a mix of three different
Externí odkaz:
https://doaj.org/article/64abe6d744964038853dbcc10cadf598
Autor:
Animesh Sharma, Voin Petrovic, Anala Nepal, Bård Helge Hoff, Steffen Bugge, Eirik Sundby, Marit Otterlei, Geir Slupphaug, Camilla Olaisen
Publikováno v:
Analytical Biochemistry. 523:10-16
The Multiplexed Inhibitor Bead (MIB) assay is a previously published quantitative proteomic MS-based approach to study cellular kinomes. A rather extensive procedure, need for multiple custom-made kinase inhibitors and an inability to re-use the MIB-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b895e42568220b90b1b90daf4e07fd3
Autor:
Steffen Bugge, Marit Otterlei, Eirik Sundby, Voin Petrovic, Animesh Sharma, Camilla Olaisen, Bård Helge Hoff, Anala Nepal, Geir Slupphaug
Publikováno v:
Data in Brief
Data in Brief, Vol 12, Iss C, Pp 18-21 (2017)
Data in Brief, Vol 12, Iss C, Pp 18-21 (2017)
Cell extracts from A549, H460, and U2OS human cancer cell lines treated with cisplatin and docetaxel were analyzed by mass spectrometry (MS) proteomic analysis. The extracts were enriched for cellular signaling proteins using a mix of three different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::536f9ab1fee8b122c954dc021ccc726b
http://europepmc.org/articles/PMC5362150
http://europepmc.org/articles/PMC5362150
Publikováno v:
18569-18577
RSC Advances
RSC Advances
With the aim of identifying new lead structures for EGFR inhibition, a study of palladium catalysed Heck coupling between (R)-6-bromo-N-(1-phenylethyl)thieno[2,3-d]pyrimidin-4-amine and various acrylates was performed. The Heck coupling was highly de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d473c3d1194cfd47119afacadfae6a8
https://hdl.handle.net/11250/2444444
https://hdl.handle.net/11250/2444444
Publikováno v:
Chemistry of Heterocyclic Compounds. 50:1177-1187
A practical, robust and scalable synthesis of 6-bromo-4-chlorothieno[2,3-d]pyrimidine starting from cheap bulk chemicals has been developed. The method involves four synthetic steps: Gewald reaction, pyrimidone formation, bromination, and chlorinatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c4e41bf7f50b3dcc7df0a90d26dd7a1
https://doi.org/10.1007/s10593-014-1579-z
https://doi.org/10.1007/s10593-014-1579-z
Autor:
Eli Kjøbli, Eirik Sundby, Svein Jacob Kaspersen, Geir Bjørkøy, Line Rydså, Steffen Bugge, Jin Han, Bård Helge Hoff, Kristin G. Nørsett
Publikováno v:
European Journal of Pharmaceutical Sciences. 59:69-82
The epidermal growth factor receptor is an important target in molecular cancer therapy. Herein, the enzymatic inhibition potential of a series of chiral and non chiral pyrrolopyrimidine based derivatives have been investigated and optimised. Overall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeba3f7c0964eaed544adc926510e6b6
https://doi.org/10.1016/j.ejps.2014.04.011
https://doi.org/10.1016/j.ejps.2014.04.011
Publikováno v:
Tetrahedron. 68:9226-9233
Three different routes have been investigated for the preparation of 6-aryl- N -(1-arylethyl)thienopyrimidin-4-amines. First the possibilities of selective Suzuki reactions on 6-bromo-4-chlorothienopyrimidine were investigated. The preference for mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe6f237e59cd2b3794d9e1a03ede04af
https://doi.org/10.1016/j.tet.2012.08.090
https://doi.org/10.1016/j.tet.2012.08.090
Publikováno v:
ChemInform. 46
The title compound (VII), a useful precursor for the synthesis of a library of thienopyrimidine-based kinase inhibitors, is obtained starting from cheap bulk chemicals in four steps.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f28ce6da472176387cb17978cdd513c
https://doi.org/10.1002/chin.201516255
https://doi.org/10.1002/chin.201516255
Publikováno v:
European journal of medicinal chemistry. 94
An approach for optimization of epidermal growth factor receptor tyrosine kinase (EGFR-TK) inhibitors using truncated thienopyrimidine structures combined with enzymatic assay has been evaluated. This was done by synthesis and EGFR activity measureme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da781867991cd3c09d954f90888555d
https://pubmed.ncbi.nlm.nih.gov/25768701
https://pubmed.ncbi.nlm.nih.gov/25768701
Autor:
Eirik Sundby, Synne Larsen, Unni Nonstad, Bård Helge Hoff, Geir Bjørkøy, Steffen Bugge, Svein Jacob Kaspersen
Publikováno v:
European journal of medicinal chemistry. 75
Based on the thieno[2,3-d]pyrimidine scaffold, a series of new 4-amino-6-aryl thienopyrimidines have been prepared and evaluated as EGFR tyrosine kinase inhibitors. The in vitro activity was found to depend strongly on the substitution pattern in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076e87fc8ead7a1f45de3cc07f6b5422
https://pubmed.ncbi.nlm.nih.gov/24556149
https://pubmed.ncbi.nlm.nih.gov/24556149