Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Steffen Bak"'
Publikováno v:
Zhao, X, Bak, S, Pedersen, A J T, Jensen, O N & Højlund, K 2014, ' Insulin increases phosphorylation of mitochondrial proteins in human skeletal muscle in vivo ', Journal of Proteome Research, vol. 13, no. 5, pp. 2359-2369 . https://doi.org/10.1021/pr401163t
There is increasing evidence that multiple proteins involved in key regulatory processes in mitochondria are phosphorylated in mammalian tissues. Insulin regulates glucose metabolism by phosphorylation-dependent signaling and has been shown to stimul
Publikováno v:
Bak, S, León, I R, Jensen, O N & Højlund, K 2013, ' Tissue specific phosphorylation of mitochondrial proteins isolated from rat liver, heart muscle, and skeletal muscle ', Journal of Proteome Research, vol. 12, no. 10, pp. 4327-4339 . https://doi.org/10.1021/pr400281r
Phosphorylation of mitochondrial proteins in a variety of biological processes is increasingly being recognized and may contribute to the differences in function and energy demands observed in mitochondria from different tissues such as liver, heart,
Autor:
Trine Christensen, Ove Wiborg, Steffen Bak, Ole N. Jensen, Christina F. Bisgaard, Jan J. Enghild
Publikováno v:
Bisgaard, C F, Bak, S, Christensen, T, Jensen, O N, Enghild, J J & Wiborg, O 2012, ' Vesicular signalling and immune modulation as hedonic fingerprints : proteomic profiling in the chronic mild stress depression model ', Journal of Psychopharmacology, vol. 26, no. 12, pp. 1569-1583 . https://doi.org/10.1177/0269881112460110
Bisgaard, C F, Bak, S, Christensen, T, Jensen, O N, Enghild, J J & Wiborg, O 2012, ' Vesicular signalling and immune modulation as hedonic fingerprints : proteomic profiling in the chronic mild stress depression model ', Journal of Psychopharmacology, vol. 26, no. 12, pp. 1569-83 . https://doi.org/10.1177/0269881112460110
Bisgaard, C F, Bak, S, Christensen, T, Jensen, O N, Enghild, J J & Wiborg, O 2012, ' Vesicular signalling and immune modulation as hedonic fingerprints : proteomic profiling in the chronic mild stress depression model ', Journal of Psychopharmacology, vol. 26, no. 12, pp. 1569-83 . https://doi.org/10.1177/0269881112460110
Extensive preclinical research has focused at unravelling the underlying molecular mechanisms leading to depression and recovery. In this study, we investigated the quantitative changes in protein abundance in the ventral hippocampal granular cell la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f5c0d7922886022e502784a33122b2
https://pure.au.dk/portal/da/publications/vesicular-signalling-and-immune-modulation-as-hedonic-fingerprints(26f80ed4-f237-4aae-9a75-651c529fb1a1).html
https://pure.au.dk/portal/da/publications/vesicular-signalling-and-immune-modulation-as-hedonic-fingerprints(26f80ed4-f237-4aae-9a75-651c529fb1a1).html
Publikováno v:
Nielsen, P F, Bak, S & Vandahl, B 2012, ' Characterization of tyrosine sulphation in rFVIII (turoctocog alfa) expressed in CHO and HEK-293 cells ', Haemophilia, vol. 18, no. 5, pp. e397-8 . https://doi.org/10.1111/j.1365-2516.2012.02881.x
Autor:
Ole N. Jensen, Clifford Young, Vladimiros Thoma, Carla Ferreri, Peter Højrup, Ida B. Thøgersen, Jan J. Enghild, Steffen Bak, Lone Nielsen, Toke P. Krogager
Publikováno v:
Journal of proteomics
75 (2012): 2685–2696. doi:10.1016/j.jprot.2012.03.023
info:cnr-pdr/source/autori:Krogager, Toke Peter; Nielsen, Lone Vendel; Bak, Steffen; Young, Clifford; Ferreri, Carla; Jensen, Ole Norregaard; Hojrup, Peter; Thoma, Vladimiros; Thogersen, Ida B.; Enghild, Jan J./titolo:Identification of a potential biomarker panel for the intake of the common dietary trans fat elaidic acid (trans Delta 9-C18:1)/doi:10.1016%2Fj.jprot.2012.03.023/rivista:Journal of proteomics (Print)/anno:2012/pagina_da:2685/pagina_a:2696/intervallo_pagine:2685–2696/volume:75
Kroager, T P, Nielsen, L V, Bak, S, Young, C, Ferreri, C, Jensen, O N, Højrup, P, Thoma, V, Thøgersen, I B & Enghild, J J 2012, ' Identification of a potential biomarker panel for the intake of the common dietary trans fat elaidic acid (trans∆9-C18:1) ', Journal of Proteomics, vol. 75, no. 9, pp. 2685-2696 . https://doi.org/10.1016/j.jprot.2012.03.023
Krogager, T P, Nielsen, L V, Bak, S, Young, C, Ferreri, C, Jensen, O N, Højrup, P, Thoma, V, Thøgersen, I & Enghild, J J 2012, ' Identification of a potential biomarker panel for the intake of the common dietary trans fat elaidic acid (trans∆9-C18:1) ', Journal of Proteomics, vol. 75, no. 9, pp. 2685-96 . https://doi.org/10.1016/j.jprot.2012.03.023
75 (2012): 2685–2696. doi:10.1016/j.jprot.2012.03.023
info:cnr-pdr/source/autori:Krogager, Toke Peter; Nielsen, Lone Vendel; Bak, Steffen; Young, Clifford; Ferreri, Carla; Jensen, Ole Norregaard; Hojrup, Peter; Thoma, Vladimiros; Thogersen, Ida B.; Enghild, Jan J./titolo:Identification of a potential biomarker panel for the intake of the common dietary trans fat elaidic acid (trans Delta 9-C18:1)/doi:10.1016%2Fj.jprot.2012.03.023/rivista:Journal of proteomics (Print)/anno:2012/pagina_da:2685/pagina_a:2696/intervallo_pagine:2685–2696/volume:75
Kroager, T P, Nielsen, L V, Bak, S, Young, C, Ferreri, C, Jensen, O N, Højrup, P, Thoma, V, Thøgersen, I B & Enghild, J J 2012, ' Identification of a potential biomarker panel for the intake of the common dietary trans fat elaidic acid (trans∆9-C18:1) ', Journal of Proteomics, vol. 75, no. 9, pp. 2685-2696 . https://doi.org/10.1016/j.jprot.2012.03.023
Krogager, T P, Nielsen, L V, Bak, S, Young, C, Ferreri, C, Jensen, O N, Højrup, P, Thoma, V, Thøgersen, I & Enghild, J J 2012, ' Identification of a potential biomarker panel for the intake of the common dietary trans fat elaidic acid (trans∆9-C18:1) ', Journal of Proteomics, vol. 75, no. 9, pp. 2685-96 . https://doi.org/10.1016/j.jprot.2012.03.023
Trans fatty acid intake has been correlated to an unfavorable plasma lipoprotein profile and an increased cardiovascular disease risk. The present study aimed to identify a plasma protein biomarker panel related to human intake of elaidic acid. The h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::916f770c75540713ebba4eea828a8959
http://www.cnr.it/prodotto/i/314679
http://www.cnr.it/prodotto/i/314679
Publikováno v:
Thingholm, T E, Bak, S, Beck-Nielsen, H, Jensen, O N & Gaster, M 2011, ' Characterization of human myotubes from type 2 diabetic and non-diabetic subjects using complementary quantitative mass spectrometric methods ', Molecular and Cellular Proteomics, vol. 10, no. 9, pp. M110.006650 . https://doi.org/10.1074/mcp.M110.006650
Skeletal muscle is a key tissue site of insulin resistance in type 2 diabetes. Human myotubes are primary skeletal muscle cells displaying both morphological and biochemical characteristics of mature skeletal muscle and the diabetic phenotype is cons
Autor:
Ole N. Jensen, Ida B. Thøgersen, Camilla Lund Nikolajsen, Carsten Scavenius, Peter Højrup, Steffen Bak, Kristian W. Sanggaard, Jan J. Enghild, Zuzana Valnickova
Publikováno v:
Sonne-Schmidt, C S, Sanggaard, K W, Nikolajsen, C L, Bak, S, Valnickova, Z, Thøgersen, I B, Jensen, O N, Højrup, P & Enghild, J J 2011, ' Human inter-α-inhibitor is a substrate for factor XIIIa and tissue transglutaminase ', BBA General Subjects, vol. 1814, no. 12, pp. 1624-30 . https://doi.org/10.1016/j.bbapap.2011.08.017
Sonne-Schmidt, C S, Sanggaard, K W, Nikolajsen, C L, Bak, S, Valnickova, Z, Thøgersen, I, Jensen, O N, Højrup, P & Enghild, J J 2011, ' Human inter-α-inhibitor is a substrate for factor XIIIa and tissue transglutaminase ', BBA General Subjects, vol. 1814, no. 12, pp. 1624-1630 . https://doi.org/10.1016/j.bbapap.2011.08.017
Sonne-Schmidt, C S, Sanggaard, K W, Nikolajsen, C L, Bak, S, Valnickova, Z, Thøgersen, I, Jensen, O N, Højrup, P & Enghild, J J 2011, ' Human inter-α-inhibitor is a substrate for factor XIIIa and tissue transglutaminase ', BBA General Subjects, vol. 1814, no. 12, pp. 1624-1630 . https://doi.org/10.1016/j.bbapap.2011.08.017
In this study, we show that inter-α-inhibitor is a substrate for both factor XIIIa and tissue transglutaminase. These enzymes catalyze the incorporation of dansylcadaverine and biotin-pentylamine, revealing that inter-α-inhibitor contains reactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7725819c747b20188e4b32a0715701c
https://pure.au.dk/portal/da/publications/human-interinhibitor-is-a-substrate-for-factor-xiiia-and-tissue-transglutaminase(486e1eb4-900f-4f1d-8949-8cfee71a61ca).html
https://pure.au.dk/portal/da/publications/human-interinhibitor-is-a-substrate-for-factor-xiiia-and-tissue-transglutaminase(486e1eb4-900f-4f1d-8949-8cfee71a61ca).html
Autor:
Krzysztof Wrzesinski, Ole N. Jensen, Steffen Bak, Ileana R. León, Xiaolu Zhao, Kurt Højlund, Martin Mogensen
Publikováno v:
Zhao, X, Leon, I R, Bak, S, Hey-Mogensen, M, Wrzesinski, K, Højlund, K & Jensen, O N 2011, ' Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes ', Molecular and Cellular Proteomics, vol. 10, no. 1 . https://doi.org/10.1074/mcp.M110.000299
Mitochondria play a central role in energy metabolism and cellular survival, and consequently mitochondrial dysfunction is associated with a number of human pathologies. Reversible protein phosphorylation emerges as a central mechanism in the regulat
Autor:
Ole N. Jensen, Niels Gregersen, Kim Henningsen, Steffen Bak, Johan Palmfeldt, Ove Wiborg, Sofie Christiansen, Isabel Baiges
Publikováno v:
Scopus-Elsevier
Henningsen, K, Palmfeldt, J, Christiansen, S F, Baiges, I, Bak, S, Jensen, O N, Gregersen, N & Wiborg, O 2012, ' Candidate hippocampal biomarkers of susceptibility and resilience to stress in a rat model of depression ', Molecular and Cellular Proteomics, vol. 11, no. 7, pp. M111.016428 . https://doi.org/10.1074/mcp.M111.016428
Henningsen, K, Palmfeldt, J, Christiansen, S, Baiges, I, Bak, S, Jensen, O N, Gregersen, N & Wiborg, O 2012, ' Candidate hippocampal biomarkers of susceptibility and resilience to stress in a rat model of depression ', Molecular and Cellular Proteomics, vol. 11, no. 7 . https://doi.org/10.1074/mcp.M111.016428
Henningsen, K, Palmfeldt, J, Christiansen, S F, Baiges, I, Bak, S, Jensen, O N, Gregersen, N & Wiborg, O 2012, ' Candidate hippocampal biomarkers of susceptibility and resilience to stress in a rat model of depression ', Molecular and Cellular Proteomics, vol. 11, no. 7, pp. M111.016428 . https://doi.org/10.1074/mcp.M111.016428
Henningsen, K, Palmfeldt, J, Christiansen, S, Baiges, I, Bak, S, Jensen, O N, Gregersen, N & Wiborg, O 2012, ' Candidate hippocampal biomarkers of susceptibility and resilience to stress in a rat model of depression ', Molecular and Cellular Proteomics, vol. 11, no. 7 . https://doi.org/10.1074/mcp.M111.016428
Susceptibility to stress plays a crucial role in the development of psychiatric disorders such as unipolar depression and post-traumatic stress disorder. In the present study, the chronic mild stress (CMS) rat model of depression was used to reveal s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a51386025aa44bc0f19bb77720ef7d
http://www.scopus.com/inward/record.url?eid=2-s2.0-84873030039&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-84873030039&partnerID=MN8TOARS
Autor:
León, Ileana R., Veit Schwämmle, James Williamson, Giuseppe Palmisano, Steffen Bak, Sprenger, Richard R., Adelina Rogowska-Wrzesinska, Ole Nørregaard Jensen
Publikováno v:
University of Southern Denmark
León, I R, Schwämmle, V, Williamson, J, Palmisano, G, Bak, S, Sprenger, R R, Rogowska-Wrzesinska, A & Jensen, O N 2012, ' Diet-induced perturbation of the rat liver mitochondrial acetylome studied by quantitative (iTRAQ) LC-MS/MS ', 60th American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics, Vancouver, Canada, 19/05/2012-24/05/2012 .
León, I R, Schwämmle, V, Williamson, J, Palmisano, G, Bak, S, Sprenger, R R, Rogowska-Wrzesinska, A & Jensen, O N 2012, ' Diet-induced perturbation of the rat liver mitochondrial acetylome studied by quantitative (iTRAQ) LC-MS/MS ', 60th American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics, Vancouver, Canada, 19/05/2012-24/05/2012 .
Introduction Post-translational modifications (PTMs) regulate protein networks in the cell. -N-acetylation of lysine residues is a reversible and highly regulated PTM, which is controlled by networks of lysine-acetyl transferases (KATs) and lysine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::29bf1988e8e6ea1f6a953857fa6bf0f6
https://portal.findresearcher.sdu.dk/en/publications/455bd9b9-5148-45d0-b8a2-cce6cdf9397c
https://portal.findresearcher.sdu.dk/en/publications/455bd9b9-5148-45d0-b8a2-cce6cdf9397c