Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Steffen, Lippold"'
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Glycosylation affects the safety and efficacy of therapeutic proteins and is often considered a critical quality attribute (CQA). Therefore, it is important to identify and quantify glycans during drug development. Glycosylation is a highly complex p
Externí odkaz:
https://doaj.org/article/c50565fa46114d0ab1802b3e7a995331
Autor:
Christoph Gstöttner, Steffen Lippold, Michaela Hook, Feng Yang, Markus Haberger, Manfred Wuhrer, David Falck, Tilman Schlothauer, Elena Domínguez-Vega
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The antibody- FcγRIIIa interaction triggers key immunological responses such as antibody dependent cellular cytotoxicity (ADCC), making it highly important for therapeutic mAbs. Due to the direct glycan-glycan interaction with FcγRIIIa receptor, di
Externí odkaz:
https://doaj.org/article/17823215efd24dc59d0603caae56befe
Autor:
Steffen Lippold, Karishma Mistry, Sunidhi Lenka, Kevin Whang, Peilu Liu, Sebastian Pitschi, Felix Kuhne, Dietmar Reusch, Lance Cadang, Alexander Knaupp, Saeed Izadi, Alexis Dunkle, Feng Yang, Tilman Schlothauer
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Human Fc gamma receptor IIa (FcγRIIa) or CD32a has two major allotypes with a single amino acid difference at position 131 (histidine or arginine). Differences in FcγRIIa allotypes are known to impact immunological responses such as the clinical ou
Externí odkaz:
https://doaj.org/article/69a3b2655a744a0981d1ba12450c4881
Autor:
Steffen Lippold, Arnoud H. de Ru, Jan Nouta, Peter A. van Veelen, Magnus Palmblad, Manfred Wuhrer, Noortje de Haan
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 3038-3051 (2020)
Glycoproteomic data are often very complex, reflecting the high structural diversity of peptide and glycan portions. The use of glycopeptide-centered glycoproteomics by mass spectrometry is rapidly evolving in many research areas, leading to a demand
Externí odkaz:
https://doaj.org/article/e76b9a3ac08a4a6f96bb7d2e0295243b
Autor:
Steffen Lippold, Simone Nicolardi, Elena Domínguez-Vega, Anna-Katharina Heidenreich, Gestur Vidarsson, Dietmar Reusch, Markus Haberger, Manfred Wuhrer, David Falck
Publikováno v:
mAbs, Vol 11, Iss 7, Pp 1191-1196 (2019)
Determination of the impact of individual antibody glycoforms on FcɣRIIIa affinity, and consequently antibody-dependent cell-mediated cytotoxicity (ADCC) previously required high purity glycoengineering. We hyphenated FcɣRIIIa affinity chromatograp
Externí odkaz:
https://doaj.org/article/29cf8fc232b146ef88ded0217ad4cb13
Autor:
Steffen Lippold, Alexander Knaupp, Arnoud H. de Ru, Rayman T. N. Tjokrodirijo, Peter A. van Veelen, Erwin van Puijenbroek, Steven W. de Taeye, Dietmar Reusch, Gestur Vidarsson, Manfred Wuhrer, Tilman Schlothauer, David Falck
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
The crystallizable fragment (Fc) of immunoglobulin G (IgG) activates key immunological responses by interacting with Fc gamma receptors (FcɣR). FcɣRIIIb contributes to neutrophil activation and is involved in antibody-dependent cellular cytotoxicit
Externí odkaz:
https://doaj.org/article/304e5e39a8ea4ca9a3464086e8534f7a
Autor:
Steffen Lippold, Michaela Hook, Christian Spick, Alexander Knaupp, Kevin Whang, Fabian Ruperti, Lance Cadang, Nisana Andersen, Annette Vogt, Michael Grote, Dietmar Reusch, Markus Haberger, Feng Yang, Tilman Schlothauer
Publikováno v:
Analytical Chemistry. 95:2260-2268
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca4f53e3f3a5ec666eb586b8553e20c3
https://doi.org/10.1021/acs.analchem.2c03827
https://doi.org/10.1021/acs.analchem.2c03827
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
Fcɤ receptors (FcɤR) mediate key functions in immunological responses. For instance, FcɤRIIIa is involved in antibody-dependent cell-mediated cytotoxicity (ADCC). FcɤRIIIa interacts with the fragment crystallizable (Fc) of immunoglobulin G (IgG).
Externí odkaz:
https://doaj.org/article/53f91e25056a454980160b796d0e8814
Autor:
Markus Haberger, Michaela Hook, Matthew S F Choo, Alexander Büttner, Terry Nguyen-Khuong, Dietmar Reusch, Coen J. de Jong, Steffen Lippold, Manfred Wuhrer, Noortje de Haan
Publikováno v:
Analytical chemistry
Analytical Chemistry, 92(14), 9476-9481. AMER CHEMICAL SOC
Analytical Chemistry, 92(14), 9476-9481. AMER CHEMICAL SOC
Recombinant human erythropoietin (rhEPO) is an important biopharmaceutical for which glycosylation is a critical quality attribute. Therefore, robust analytical methods are needed for the in-depth characterization of rhEPO glycosylation. Currently, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800309a7d07a23061d9009ecbe96471a
https://doi.org/10.1021/acs.analchem.0c01794
https://doi.org/10.1021/acs.analchem.0c01794
Publikováno v:
Analytica Chimica Acta, 1185. ELSEVIER
Analytica chimica acta
Analytica chimica acta
Recombinant human erythropoietin (EPO) is a complex therapeutic glycoprotein with three N- and one O-glycosylation sites. Glycosylation of EPO influences its safety and efficacy and is defined as a critical quality attribute. Thus, analytical methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf9b7460ca39369da2efce5a4034a15
https://hdl.handle.net/1887/3246775
https://hdl.handle.net/1887/3246775
