Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Steffany A L Bennett"'
Autor:
Peyman Ghorbani, Sang Yong Kim, Tyler K T Smith, Lucía Minarrieta, Victoria Robert-Gostlin, Marisa K Kilgour, Maja Ilijevska, Irina Alecu, Shayne A Snider, Kaitlyn D Margison, Julia R C Nunes, Daniel Woo, Ciara Pember, Conor O'Dwyer, Julie Ouellette, Pavel Kotchetkov, Julie St-Pierre, Steffany A L Bennett, Baptiste Lacoste, Alexandre Blais, Meera G Nair, Morgan D Fullerton
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011658 (2023)
Type 2 cytokines like IL-4 are hallmarks of helminth infection and activate macrophages to limit immunopathology and mediate helminth clearance. In addition to cytokines, nutrients and metabolites critically influence macrophage polarization. Choline
Externí odkaz:
https://doaj.org/article/90d98c83331e4ab19bdf970a30da6155
Autor:
Federico Torta, Nils Hoffmann, Bo Burla, Irina Alecu, Makoto Arita, Takeshi Bamba, Steffany A. L. Bennett, Justine Bertrand-Michel, Britta Brügger, Mónica P. Cala, Dolores Camacho-Muñoz, Antonio Checa, Michael Chen, Michaela Chocholoušková, Michelle Cinel, Emeline Chu-Van, Benoit Colsch, Cristina Coman, Lisa Connell, Bebiana C. Sousa, Alex M. Dickens, Maria Fedorova, Finnur Freyr Eiríksson, Hector Gallart-Ayala, Mohan Ghorasaini, Martin Giera, Xue Li Guan, Mark Haid, Thomas Hankemeier, Amy Harms, Marcus Höring, Michal Holčapek, Thorsten Hornemann, Chunxiu Hu, Andreas J. Hülsmeier, Kevin Huynh, Christina M. Jones, Julijana Ivanisevic, Yoshihiro Izumi, Harald C. Köfeler, Sin Man Lam, Mike Lange, Jong Cheol Lee, Gerhard Liebisch, Katrice Lippa, Andrea F. Lopez-Clavijo, Malena Manzi, Manuela R. Martinefski, Raviswamy G. H. Math, Satyajit Mayor, Peter J. Meikle, María Eugenia Monge, Myeong Hee Moon, Sneha Muralidharan, Anna Nicolaou, Thao Nguyen-Tran, Valerie B. O’Donnell, Matej Orešič, Arvind Ramanathan, Fabien Riols, Daisuke Saigusa, Tracey B. Schock, Heidi Schwartz-Zimmermann, Guanghou Shui, Madhulika Singh, Masatomo Takahashi, Margrét Thorsteinsdóttir, Noriyuki Tomiyasu, Anthony Tournadre, Hiroshi Tsugawa, Victoria J. Tyrrell, Grace van der Gugten, Michael O. Wakelam, Craig E. Wheelock, Denise Wolrab, Guowang Xu, Tianrun Xu, John A. Bowden, Kim Ekroos, Robert Ahrends, Markus R. Wenk
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract In this community effort, we compare measurements between 34 laboratories from 19 countries, utilizing mixtures of labelled authentic synthetic standards, to quantify by mass spectrometry four clinically used ceramide species in the NIST (Na
Externí odkaz:
https://doaj.org/article/e8653562ef70466097f27cb7fad363e8
Autor:
Michael A Kennedy, Kenneth Gable, Karolina Niewola-Staszkowska, Susana Abreu, Anne Johnston, Linda J Harris, Fulvio Reggiori, Robbie Loewith, Teresa Dunn, Steffany A L Bennett, Kristin Baetz
Publikováno v:
PLoS Genetics, Vol 10, Iss 1, p e1004010 (2014)
Unbiased lipidomic approaches have identified impairments in glycerophosphocholine second messenger metabolism in patients with Alzheimer's disease. Specifically, we have shown that amyloid-β42 signals the intraneuronal accumulation of PC(O-16:0/2:0
Externí odkaz:
https://doaj.org/article/c7e06b2f45804822aea12b8b20a5a089
Autor:
Steffany A L Bennett, Nicolas eValenzuela, Hongbin eXu, Bettina eFranko, Stephen eFai, Daniel eFigeys
Publikováno v:
Frontiers in Physiology, Vol 4 (2013)
Not all of the mysteries of life lie in our genetic code. Some can be found buried in our membranes. These shells of fat, sculpted in the central nervous system into the cellular (and subcellular) boundaries of neurons and glia, are themselves comple
Externí odkaz:
https://doaj.org/article/2d2e0b3d66614870bbb28a1363e833aa
Autor:
Michael A Kennedy, Nazir Kabbani, Jean-Philippe Lambert, Leigh Anne Swayne, Fida Ahmed, Daniel Figeys, Steffany A L Bennett, Jennnifer Bryan, Kristin Baetz
Publikováno v:
PLoS Genetics, Vol 7, Iss 2, p e1001299 (2011)
During Alzheimer's Disease, sustained exposure to amyloid-β₄₂ oligomers perturbs metabolism of ether-linked glycerophospholipids defined by a saturated 16 carbon chain at the sn-1 position. The intraneuronal accumulation of 1-O-hexadecyl-2-acety
Externí odkaz:
https://doaj.org/article/c740e768ae3545188d826512e6fe04b5
Autor:
Francesco Monti, David Stewart, Anuradha Surendra, Irina Alecu, Thao Nguyen-Tran, Steffany A L Bennett, Miroslava Čuperlović-Culf
Publikováno v:
Bioinformatics. 39
Motivation There is a need for easily accessible implementations that measure the strength of both linear and non-linear relationships between metabolites in biological systems as an approach for data-driven network development. While multiple tools
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2553
Computational cell metabolism models seek to provide metabolic explanations of cell behavior under different conditions or following genetic alterations, help in the optimization of in vitro cell growth environments, or predict cellular behavior in v
Autor:
Mijin Jung, Steffany A. L. Bennett, Miroslava Cuperlovic-Culf, Anuradha Surendra, Brian D. Green, Anthony Peter Passmore, David E. Beverland, Hossen Teimoorinia, Xiaobei Pan, Emma L. Cunningham, Bernadette McGuiness
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Cuperlovic-Culf, M, Cunningham, E L, Teimoorinia, H, Surendra, A, Pan, X, Bennett, S A L, Jung, M, McGuiness, B, Passmore, A P, Beverland, D & Green, B D 2021, ' Metabolomics and computational analysis of the role of monoamine oxidase activity in delirium and SARS-COV-2 infection ', Scientific Reports, vol. 11, no. 1, 10629, pp. 10629 . https://doi.org/10.1038/s41598-021-90243-1, https://doi.org/10.1038/s41598-021-90243-1
Scientific Reports
Cuperlovic-Culf, M, Cunningham, E L, Teimoorinia, H, Surendra, A, Pan, X, Bennett, S A L, Jung, M, McGuiness, B, Passmore, A P, Beverland, D & Green, B D 2021, ' Metabolomics and computational analysis of the role of monoamine oxidase activity in delirium and SARS-COV-2 infection ', Scientific Reports, vol. 11, no. 1, 10629, pp. 10629 . https://doi.org/10.1038/s41598-021-90243-1, https://doi.org/10.1038/s41598-021-90243-1
Delirium is an acute change in attention and cognition occurring in ~65% of severe SARS-CoV-2 cases. It is also common following surgery and an indicator of brain vulnerability and risk for the development of dementia. In this work we analyzed the un
Autor:
Kyle N. Cowan, Tommy Alain, Stephen Baird, Xiao Xiang, Stéphanie Langlois, Tyson E. Graber, Marie-Eve St-Pierre, Stephanie L. Fowler, Anna Blinder, Steffany A. L. Bennett, Philippe Charron
Publikováno v:
Oncogene
Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children, is an aggressive cancer with a poor prognosis. Despite current management, the 5-year survival rate for patients with metastatic RMS is ∼30%; underscoring the need to develop
Autor:
Emily Hashimoto-Roth, Anuradha Surendra, Mathieu Lavallée-Adam, Steffany A L Bennett, Miroslava Čuperlović-Culf
Motivation Class imbalance, or unequal sample sizes between classes, is an increasing concern in machine learning for metabolomic and lipidomic data mining, which can result in overfitting for the over-represented class. Numerous methods have been de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efdeee94c2796e43d7f97e2b956a3d0f
https://doi.org/10.1101/2022.04.21.489108
https://doi.org/10.1101/2022.04.21.489108