Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Steffanie, Sabbaj"'
Duration of post–COVID-19 symptoms is associated with sustained SARS-CoV-2–specific immune responses
Autor:
Jacob K. Files, Sanghita Sarkar, Tim R. Fram, Sushma Boppana, Sarah Sterrett, Kai Qin, Anju Bansal, Dustin M. Long, Steffanie Sabbaj, James J. Kobie, Paul A. Goepfert, Nathan Erdmann
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
A subset of COVID-19 patients exhibit post-acute sequelae of COVID-19 (PASC), but little is known about the immune signatures associated with these syndromes. We investigated longitudinal peripheral blood samples in 50 individuals with previously con
Externí odkaz:
https://doaj.org/article/f646bc9bc0794fd78c4a08d2e516920f
Autor:
Eric Carlin, Braxton Greer, Kelsey Lowman, Alexandra Duverger, Frederic Wagner, David Moylan, Alexander Dalecki, Shekwonya Samuel, Mildred Perez, Steffanie Sabbaj, Olaf Kutsch
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1008748 (2021)
The biomolecular mechanisms controlling latent HIV-1 infection, despite their importance for the development of a cure for HIV-1 infection, are only partially understood. For example, ex vivo studies have recently shown that T cell activation only tr
Externí odkaz:
https://doaj.org/article/ad4ecc2c0cd44cc490fae2f38c691585
Autor:
Skye, Opsteen, David, Moylan, Babafemi O, Taiwo, Kevin R, Robertson, E Turner, Overton, Gary R, Cutter, Steffanie, Sabbaj, Sonya L, Heath, John J, Shacka
Publikováno v:
JAIDS Journal of Acquired Immune Deficiency Syndromes. 91:485-489
With advances in HIV treatment, people with HIV (PWH) are living longer but experience aging-related comorbidities, including cognitive deficits, at higher rates than the general population. Previous studies have shown alterations in lysosomal protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a76759d689e6fc928dc17d04425d75d8
https://doi.org/10.1097/qai.0000000000003086
https://doi.org/10.1097/qai.0000000000003086
Autor:
David C. Moylan, Paul A. Goepfert, Mirjam-Colette Kempf, Michael S. Saag, Holly E. Richter, Jiri Mestecky, Steffanie Sabbaj
Publikováno v:
Pathogens and Immunity, Vol 1, Iss 2, Pp 371-389 (2017)
Background:Tissue resident memory T cells (TrM) provide an enhanced response against infection at mucosal surfaces, yet their function has not been extensively studied in humans, including the female genital tract (FGT). Methods: Using polychromatic
Externí odkaz:
https://doaj.org/article/1380b56cadd54ea185106b344ec7bcd8
Autor:
Qiana L. Matthews, Anitra L. Farrow, Girish Rachakonda, Linlin Gu, Pius Nde, Alexandre Krendelchtchikov, Siddarth Pratap, Shruti S. Sakhare, Steffanie Sabbaj, Maria F. Lima, Fernando Villalta
Publikováno v:
Pathogens and Immunity, Vol 1, Iss 2, Pp 214-233 (2016)
Background: Previously we reported that a hexon-modified adenovirus (Ad) vector containing the invasive neutralizing epitope of Trypanosoma cruzi (T. cruzi) trypomastigote gp83 (Ad5-gp83) provided immunoprotection against T. cruzi infection. The purp
Externí odkaz:
https://doaj.org/article/bd0d3cb000fb4d4c80ce6a4ba23b0968
Autor:
Steffanie Sabbaj, Jiri Mestecky
Publikováno v:
Curr Immunol Rev
The mucosal immune systems of the genital and intestinal tracts are considered as the most frequent sites of HIV-1 entry, displaying remarkable immunological differences in the systemic immune compartment which must be considered in the evaluation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14239c6292faf66979a583623605e7a7
https://doi.org/10.2174/1573395514666180621152303
https://doi.org/10.2174/1573395514666180621152303
Duration of post-COVID-19 symptoms is associated with sustained SARS-CoV-2-specific immune responses
Autor:
Timothy R Fram, Kai Qin, Paul A. Goepfert, James J. Kobie, Nathan Erdmann, Anju Bansal, Steffanie Sabbaj, Sarah Sterrett, Jacob K Files, Sanghita Sarkar, Dustin M. Long, Sushma Boppana
Publikováno v:
JCI Insight
A subset of COVID-19 patients exhibit post-acute sequelae of COVID-19 (PASC), but little is known about the immune signatures associated with these syndromes. We investigated longitudinal peripheral blood samples in 50 individuals with previously con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3322ad30bb70407f0d2e9d7504615e18
https://pubmed.ncbi.nlm.nih.gov/34143754
https://pubmed.ncbi.nlm.nih.gov/34143754
Autor:
Christopher M. Tidwell, Mildred Perez, Mingce Zhang, Alexandra Duverger, Frederic Wagner, Randy Q Cron, Steffanie Sabbaj, Olaf Kutsch
Publikováno v:
The Journal of Immunology. 208:182.17-182.17
We have demonstrated that the tetraspanin CD151 marks a hyperactivated, pro-inflammatory human CD4+ T cell population. Expansion of this population in HIV patients on ART may explain the associated risk of inflammation-related co-morbidities. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c185171b0acb229ea7af98128d6ff402
https://doi.org/10.4049/jimmunol.208.supp.182.17
https://doi.org/10.4049/jimmunol.208.supp.182.17
Autor:
Mildred Perez, Kelsey Lowman, David C. Moylan, Christopher M. Tidwell, Andrew Schroeder, Alexandra Duverger, Frederic H. Wagner, Nathan Erdmann, Paul Goepfert, Hui Hu, Steffanie Sabbaj, Olaf Kutsch
Publikováno v:
The Journal of Immunology. 208:160.10-160.10
We recently reported that in humans the tetraspanin CD151 marks phenotypically distinct T cell subsets. The frequency of CD151+ T cells differs between T cell lineages and in between memory T cell populations. CD151+ T cells are hyper-proliferative a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fecc3c97edb2741d7b71620227b846e
https://doi.org/10.4049/jimmunol.208.supp.160.10
https://doi.org/10.4049/jimmunol.208.supp.160.10
Autor:
Nathan Erdmann, Chander Raman, Steffanie Sabbaj, Alexandra Duverger, Jayme E. Locke, Hui Hu, Eric Carlin, Vishal Sharma, Kelsey E. Lowman, David C. Moylan, Shekwonya Samuel, Mildred D. Perez, Olaf Kutsch, Frederic Wagner, Christopher Tidwell, Brandon J. Pope, Lillian Seu
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Scientific Reports
Tetraspanins are a family of proteins with an array of functions that are well studied in cancer biology, but their importance in immunology is underappreciated. Here we establish the tetraspanin CD151 as a unique marker of T-cell activation and, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a9dec973c87abd707433b7b95bc6c7
https://doi.org/10.1038/s41598-020-72719-8
https://doi.org/10.1038/s41598-020-72719-8