Decreased resistance to gemcitabine (2', 2'- difluorodeoxycytidine) of cytosine-arabinoside resistant myeloblastic murine and rat leukemia cell lines: role of altered activity and substrate specificity of deoxycytidne kinase

Autor: Herbert M. Pinedo, Godefridus J. Peters, Albert Leyva, Steffan Eriksson, Ans P. M. Jongsma, G. Veerman, Andries M. Bergman, Marjoleine Brouwer, Veronique W.T. Ruiz van Haperen

Publikováno v: Biochemical Pharmacology, 57, 397-406. Elsevier Inc.
Bergman, A M, Pinedo, H M, Jongsma, A P M, Brouwer, M, van Ruiz van Haperen, V W T, Veerman, G, Leyva, A, Eriksson, S & Peters, G J 1999, ' Decreased resistance to gemcitabine (2', 2'-difluorodeoxycytidine) of cytosine-arabinoside resistant myeloblastic murine and rat leukemia cell lines: role of altered activity and substrate specificity of deoxycytidne kinase ', Biochemical Pharmacology, vol. 57, pp. 397-406 . https://doi.org/10.1016/S0006-2952(98)00318-9

We determined the potential activity of 2',2'-difluorodeoxycytidine (gemcitabine, dFdC) in 1-beta-D-arabinofuranosylcytidine (ara-C)-sensitive and-resistant leukemia cell lines. Both drugs are phosphorylated by deoxycytidine kinase (dCK); the triphos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa72ebb365fc0f7b35448741b96022e
https://doi.org/10.1016/s0006-2952(98)00318-9