Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Steff De Graef"'
Autor:
Madeline Loffredo, Hector Lucero, Da-Yuan Chen, Aoife O’Connell, Simon Bergqvist, Ahmad Munawar, Asanga Bandara, Steff De Graef, Stephen D. Weeks, Florian Douam, Mohsan Saeed, Ali H. Munawar
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract The lack of coronavirus-specific antiviral drugs has instigated multiple drug repurposing studies to redirect previously approved medicines for the treatment of SARS-CoV-2, the coronavirus behind the ongoing COVID-19 pandemic. A recent, larg
Externí odkaz:
https://doaj.org/article/e07d8710ce004328ab2ec83a48a74f35
Autor:
Baole Zhang, Luping Pang, Manesh Nautiyal, Steff De Graef, Bharat Gadakh, Eveline Lescrinier, Jef Rozenski, Sergei V. Strelkov, Stephen D. Weeks, Arthur Van Aerschot
Publikováno v:
Molecules, Vol 25, Iss 20, p 4751 (2020)
Aminoacyl-tRNA synthetases (aaRSs) have become viable targets for the development of antimicrobial agents due to their crucial role in protein translation. A series of six amino acids were coupled to the purine-like 7-amino-5-hydroxymethylbenzimidazo
Externí odkaz:
https://doaj.org/article/1539736222b44698a5e71c211dda45c2
Autor:
Manesh Nautiyal, Bharat Gadakh, Steff De Graef, Luping Pang, Masroor Khan, Yi Xun, Jef Rozenski, Arthur Van Aerschot
Publikováno v:
Antibiotics, Vol 8, Iss 4, p 180 (2019)
Emerging antibiotic resistance in pathogenic bacteria and reduction of compounds in the existing antibiotics discovery pipeline is the most critical concern for healthcare professionals. A potential solution aims to explore new or existing targets/co
Externí odkaz:
https://doaj.org/article/ad75fea30d8442fb823e1cc75a1150a8
Autor:
Arthur Van Aerschot, Steff De Graef, Sergei V. Strelkov, Manesh Nautiyal, Jef Rozenski, Stephen D. Weeks, L. Pang, Wim M. De Borggraeve, Dries De Ruysscher
Publikováno v:
European Journal of Medicinal Chemistry. 174:252-264
The superfamily of adenylate-forming enzymes all share a common chemistry. They activate a carboxylate group, on a specific substrate, by catalyzing the formation of a high energy mixed phosphoanhydride-linked nucleoside intermediate. Members of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813f06cb5f8df483d30f678a84e36d3b
https://doi.org/10.1016/j.ejmech.2019.04.045
https://doi.org/10.1016/j.ejmech.2019.04.045
Autor:
Florian Douam, Simon Bergqvist, Ali H Munawar, Aoife O'Connell, Mohsan Saeed, Ahmad Munawar, Hector Lucero, Asanga Bandara, Steff De Graef, Da-Yuan Chen, Madeline Loffredo, Stephen D. Weeks
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific Reports
Scientific Reports
The lack of coronavirus-specific antiviral drugs has instigated multiple drug repurposing studies to redirect previously approved medicines for the treatment of SARS-CoV-2, the coronavirus behind the ongoing COVID-19 pandemic. A recent, large-scale,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a660accc31502a688ace1bb125a5eaae
https://doi.org/10.1038/s41598-021-84782-w
https://doi.org/10.1038/s41598-021-84782-w
Autor:
Bao-Le Zhang, Stephen D. Weeks, Arthur Van Aerschot, Manesh Nautiyal, Steff De Graef, Sergei V. Strelkov, L. Pang, Eveline Lescrinier, Jef Rozenski, Bharat Gadakh
Publikováno v:
Molecules, Vol 25, Iss 4751, p 4751 (2020)
Molecules
Volume 25
Issue 20
'Molecules ', vol: 25, pages: 4751-1-4751-24 (2020)
Molecules
Volume 25
Issue 20
'Molecules ', vol: 25, pages: 4751-1-4751-24 (2020)
Aminoacyl-tRNA synthetases (aaRSs) have become viable targets for the development of antimicrobial agents due to their crucial role in protein translation. A series of six amino acids were coupled to the purine-like 7-amino-5-hydroxymethylbenzimidazo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fddd7749abe64e3120aeb6bdb0194a3
https://www.mdpi.com/1420-3049/25/20/4751
https://www.mdpi.com/1420-3049/25/20/4751
Autor:
Madeline Loffredo, Hector Lucero, Da-Yuan Chen, Aoife O’Connell, Simon Bergqvist, Ahmad Munawar, Asanga Bandara, Steff De Graef, Stephen D. Weeks, Florian Douam, Mohsan Saeed, Ali H. Munawar
The lack of coronavirus-specific antiviral drugs has instigated multiple drug repurposing studies to redirect previously approved medicines for the treatment of SARS-CoV-2, the coronavirus behind the ongoing COVID-19 pandemic. A recent, large-scale,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57c3b383e228b190e9242782feea483a
https://doi.org/10.1101/2020.07.15.203059
https://doi.org/10.1101/2020.07.15.203059
Autor:
Eveline Lescrinier, Dries De Ruysscher, Jef Rozenski, Charles-Alexandre Mattelaer, Sergei V. Strelkov, Arthur Van Aerschot, Stephen D. Weeks, Manesh Nautiyal, Steff De Graef, L. Pang
Publikováno v:
Bioorganicmedicinal chemistry. 28(15)
Antimicrobial resistance is considered as one of the major threats for the near future as the lack of effective treatments for various infections would cause more deaths than cancer by 2050. The development of new antibacterial drugs is considered as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a437580e7e380f3754a2b2ab4f86ba4
https://pubmed.ncbi.nlm.nih.gov/32631562
https://pubmed.ncbi.nlm.nih.gov/32631562
Autor:
Luping Pang, Manesh Nautiyal, Steff De Graef, Bharat Gadakh, Valentina Zorzini, Anastassios Economou, Sergei V. Strelkov, Arthur Van Aerschot, Stephen D. Weeks
Publikováno v:
ACS chemical biology. 15(2)
The pyrimidine-containing Trojan horse antibiotics albomycin and a recently discovered cytidine-containing microcin C analog target the class II seryl- and aspartyl-tRNA synthetases (serRS and aspRS), respectively. The active components of these comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b352969edef6bb86343c25556f068bec
https://pubmed.ncbi.nlm.nih.gov/31869198
https://pubmed.ncbi.nlm.nih.gov/31869198
Autor:
Yi Xun, Jef Rozenski, Arthur Van Aerschot, Bharat Gadakh, Manesh Nautiyal, L. Pang, Masroor Khan, Steff De Graef
Publikováno v:
Antibiotics, Vol 8, Iss 4, p 180 (2019)
Antibiotics
Volume 8
Issue 4
Antibiotics
Volume 8
Issue 4
Emerging antibiotic resistance in pathogenic bacteria and reduction of compounds in the existing antibiotics discovery pipeline is the most critical concern for healthcare professionals. A potential solution aims to explore new or existing targets/co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d66d7fa721a9393ac321620b96e00e
https://www.mdpi.com/2079-6382/8/4/180
https://www.mdpi.com/2079-6382/8/4/180