FGF2 Induces Migration of Human Bone Marrow Stromal Cells by Increasing Core Fucosylations on N-Glycans of Integrins

Autor: Baarkullah Awan, David Turkov, Cameron Schumacher, Antonio Jacobo, Amber McEnerney, Ashley Ramsey, Gege Xu, Dayoung Park, Stefanos Kalomoiris, Wei Yao, Li-En Jao, Miguel L. Allende, Carlito B. Lebrilla, Fernando A. Fierro

Publikováno v: Stem Cell Reports, Vol 11, Iss 2, Pp 325-333 (2018)

Summary: Since hundreds of clinical trials are investigating the use of multipotent stromal cells (MSCs) for therapeutic purposes, effective delivery of the cells to target tissues is critical. We have found an unexplored mechanism, by which basic fi

Externí odkaz: https://doaj.org/article/ce444aabfa97499b803810207be599ce

Preclinical evaluation of mesenchymal stem cells overexpressing VEGF to treat critical limb ischemia

Autor: Julie R Beegle, Nataly Lessa Magner, Stefanos Kalomoiris, Aja Harding, Ping Zhou, Catherine Nacey, Jeannine Logan White, Karen Pepper, William Gruenloh, Geralyn Annett, Jan A Nolta, Fernando A Fierro

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)

Numerous clinical trials are utilizing mesenchymal stem cells (MSC) to treat critical limb ischemia, primarily for their ability to secrete signals that promote revascularization. These cells have demonstrated clinical safety, but their efficacy has

Externí odkaz: https://doaj.org/article/f5d2146d36424c12ac8287fae4099f7b

Mesenchymal Stem Cells Respond to Hypoxia by Increasing Diacylglycerols

Autor: Kinga Lakatos, Stefanos Kalomoiris, Jan A. Nolta, Fernando A. Fierro, Béla Merkely

Publikováno v: Journal of Cellular Biochemistry. 117:300-307

Mesenchymal stem cells (MSC) are currently being tested clinically for a plethora of conditions, with most approaches relying on the secretion of paracrine signals by MSC to modulate the immune system, promote wound healing, and induce angiogenesis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::486ecf9db2a8934eee857e3f2d59662e
https://doi.org/10.1002/jcb.25292

Allele-Specific Reduction of the Mutant Huntingtin Allele Using Transcription Activator-Like Effectors in Human Huntington's Disease Fibroblasts

Autor: Kyle D. Fink, Joseph S. Anderson, Anvita Komarla, Johnathon D. Anderson, Audrey Torrest, David J. Segal, Peter Deng, Stefanos Kalomoiris, Vicki L. Wheelock, Alexandra Duffy, Josh Gutierrez, Teresa Tempkin, Jan A. Nolta, William Gruenloh, Geralyn Annett, Whitney Cary

Publikováno v: Cell transplantation, vol 25, iss 4
Cell Transplantation, Vol 25 (2016)
Fink, KD; Deng, P; Gutierrez, J; Anderson, JS; Torrest, A; Komarla, A; et al.(2016). Allele-specific reduction of the mutant huntingtin allele using transcription activator-like effectors in human huntington’s disease fibroblasts. Cell Transplantation, 25(4), 677-686. doi: 10.3727/096368916X690863. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/93x8z46g

© 2016 Cognizant, LLC. Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by an abnormal expansion of CAG repeats. Although pathogenesis has been attributed to this polyglutamine expansion, the underlying mechanis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46bfd6e38b90b92ff0b5eaacc1c782a0
https://escholarship.org/uc/item/93x8z46g

Mesenchymal stem cells for the sustained in vivo delivery of bioactive factors

Autor: Scott D. Olson, Suzanne Pontow, Yunjoon Jung, Todd E. Meyerrose, Jan A. Nolta, Geralyn Annett, Gerhard Bauer, Stefanos Kalomoiris

Publikováno v: Advanced Drug Delivery Reviews. 62:1167-1174

Mesenchymal stem cells (MSC) are a promising tool for cell therapy, either through direct contribution to the repair of bone, tendon and cartilage or as an adjunct therapy through protein production and immune mediation. They are an attractive vehicl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed3510413293b8e8c1dae4ddb3c6e757
https://doi.org/10.1016/j.addr.2010.09.013