Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Stefano Woltersdorf"'
Autor:
Xiaomin Ni, Apirat Chaikuad, Simone Schierle, Stefano Woltersdorf, Espen Schallmayer, Riccardo Ronchetti, Daniel Merk, Ewgenij Proschak, Beatrice Renelt, Felix F Lillich, Stefan Knapp
Publikováno v:
Journal of medicinal chemistry. 64(8)
The retinoid X receptors (RXR) are ligand-activated transcription factors involved in multiple regulatory networks as universal heterodimer partners for nuclear receptors. Despite their high therapeutic potential in many pathologies, targeting of RXR
Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain
Autor:
Stefano Woltersdorf, Thomas Duflot, Christophe Morisseau, Victor Hernandez-Olmos, Ewgenij Proschak, Apirat Chaikuad, Franca-M Klingler, Sandra K. Wittmann, Felix Knöll, Dieter Steinhilber, Jan S. Kramer, Felix F Lillich, Angelo Sala, Kerstin Hiesinger, Daniel Merk, Sylvain Fraineau, Jeremy Bellien, Bruce D. Hammock, Jan Heering, Steffen Brunst, Stefan Knapp, G. Enrico Rovati, Julie Rondeaux, Denys Pogoryelov, Carola Buccellati, Matthieu Leuillier
Publikováno v:
J Med Chem
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2019, 62 (18), pp.8443-8460. ⟨10.1021/acs.jmedchem.9b00445⟩
Journal of medicinal chemistry, vol 62, iss 18
Journal of Medicinal Chemistry, American Chemical Society, 2019, 62 (18), pp.8443-8460. ⟨10.1021/acs.jmedchem.9b00445⟩
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2019, 62 (18), pp.8443-8460. ⟨10.1021/acs.jmedchem.9b00445⟩
Journal of medicinal chemistry, vol 62, iss 18
Journal of Medicinal Chemistry, American Chemical Society, 2019, 62 (18), pp.8443-8460. ⟨10.1021/acs.jmedchem.9b00445⟩
International audience; The emerging pharmacological target soluble epoxide hydrolase (sEH) is a bifunctional enzyme exhibiting two different catalytic activities that are located in two distinct domains. Although the physiological role of the C-term
Autor:
Carlo Angioni, Bettina Hofmann, Felix F Lillich, Manfred Schubert-Zsilavecz, Jessica Roos, Stefano Woltersdorf, Holger Stark, Michael Rühl, Mario Wurglics, Ann-Kathrin Häfner, Dieter Steinhilber, Simon B.M. Kretschmer, Dominik Vogt, Michael Karas, Astrid Kaiser, Gerd Geisslinger, Isabelle V. Maucher
Publikováno v:
Biochemical Pharmacology. 123:52-62
5-Lipoxygenase (5-LO, EC1.13.11.34) has been implicated in the pathogenesis of inflammatory and immune diseases. Recently, aminothiazole comprising inhibitors have been discovered for this valuable target. Yet, the molecular mode of action of this cl
Autor:
Stefano Woltersdorf, Dominik Vogt, Holger Stark, Simon B.M. Kretschmer, Ann-Kathrin Häfner, Bettina Hofmann, Dieter Steinhilber, Carmen B. Rödl
Publikováno v:
Future Medicinal Chemistry. 8:149-164
Background: Leukotrienes are pivotal lipid mediators in various immune and inflammatory reactions. Herein, 5-LO is a validated target. 2-Aminothiazoles, as a privileged structure, implicate known 5-LO inhibitors like ST-1083 (IC50 [polymorphonuclear
Autor:
Jan S. Kramer, Ewgenij Proschak, Stefan Knapp, Stefano Woltersdorf, Franca Maria Klingler, Daniel Merk, Apirat Chaikuad, Denys Pogoryelov, G. Enrico Rovati, Jan Heering, Kerstin Hiesinger, Dieter Steinhilber, Sandra K. Wittmann
Publikováno v:
The FASEB Journal. 32
The soluble epoxide Hydrolase (sEH) is an emerging pharmacological target. The enzyme is an antiparallel homodimer, where each of the two subunits is composed of a C-terminal hydrolase domain conne...