Tyr Phosphatase-Mediated P-ERK Inhibition Suppresses Senescence in EIA + v-raf Transformed Cells, Which, Paradoxically, Are Apoptosis-Protected in a MEK-Dependent Manner

Autor: Angela Lombardi, Stefania De Vitis, Corrado Garbi, Francesco Beguinot, Claudia Miele, Giuseppe Terrazzano, Antonella Sonia Treglia, Luca Ulianich, Stefano Turco, Bruno Di Jeso

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 2, Pp 120-130 (2011)
Neoplasia (N.Y.N.Y.) 13 (2011): 120–130.
info:cnr-pdr/source/autori:De Vitis S, Sonia Treglia A, Ulianich L, Turco S, Terrazzano G, Lombardi A, Miele C, Garbi C, Beguinot F, Di Jeso B. Source/titolo:Tyr phosphatase-mediated P-ERK inhibition suppresses senescence in EIA + v-raf transformed cells, which, paradoxically, are apoptosis-protected in a MEK-dependent manner./doi:/rivista:Neoplasia (N.Y.N.Y.)/anno:2011/pagina_da:120/pagina_a:130/intervallo_pagine:120–130/volume:13

Activation of the Ras-Raf–extracellular signal–regulated kinase (ERK) pathway causes not only proliferation and suppression of apoptosis but also the antioncogenic response of senescence. How these contrasting effects are reconciled to achieve ce

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http://www.sciencedirect.com/science/article/pii/S1476558611800515