Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Stefano Stifani"'
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract The fatal motor neuron (MN) disease Amyotrophic Lateral Sclerosis (ALS) is characterized by progressive MN degeneration. Phrenic MNs (phMNs) controlling the activity of the diaphragm are prone to degeneration in ALS, leading to death by resp
Externí odkaz:
https://doaj.org/article/078cfe787e3142ed94591df421abc24d
Spinal cord extracts of amyotrophic lateral sclerosis spread TDP-43 pathology in cerebral organoids.
Autor:
Yoshitaka Tamaki, Jay P Ross, Paria Alipour, Charles-Étienne Castonguay, Boting Li, Helene Catoire, Daniel Rochefort, Makoto Urushitani, Ryosuke Takahashi, Joshua A Sonnen, Stefano Stifani, Patrick A Dion, Guy A Rouleau
Publikováno v:
PLoS Genetics, Vol 19, Iss 2, p e1010606 (2023)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder caused by progressive loss of motor neurons and there is currently no effective therapy. Cytoplasmic mislocalization and aggregation of TAR DNA-binding protein 43 kDa (TDP-43)
Externí odkaz:
https://doaj.org/article/95522895ecef4007a675cea94277e3f9
Publikováno v:
ASN Neuro, Vol 14 (2022)
As the resident immune cells of the healthy nervous system, homeostatic microglia can rapidly become activated in response to injury/disease. Dysregulated microglia activation is a hallmark of nervous system disorders including neurodegenerative dise
Externí odkaz:
https://doaj.org/article/f5705b9d633542ef93cfdbb58b9544ea
Publikováno v:
ASN Neuro, Vol 14 (2022)
Human induced pluripotent stem cells (hiPSCs) derived from healthy and diseased individuals can give rise to many cell types, facilitating the study of mechanisms of development, human disease modeling, and early drug target validation. In this conte
Externí odkaz:
https://doaj.org/article/b65422215b524a379ea4e05656ccf482
Autor:
Stefano Stifani
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Astrocytes are a large group of glial cells that perform a variety of physiological functions in the nervous system. They provide trophic, as well as structural, support to neuronal cells. Astrocytes are also involved in neuroinflammatory processes c
Externí odkaz:
https://doaj.org/article/edd64c629b874b79b5f3de170f3d6f11
Autor:
Morena Zusso, Valentina Lunardi, Davide Franceschini, Andrea Pagetta, Rita Lo, Stefano Stifani, Anna Chiara Frigo, Pietro Giusti, Stefano Moro
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-12 (2019)
Abstract Background Neuroinflammation is the response of the central nervous system to events that interfere with tissue homeostasis and represents a common denominator in virtually all neurological diseases. Activation of microglia, the principal im
Externí odkaz:
https://doaj.org/article/d31803726c584eb9849751cbda8933b8
Autor:
Vincent Soubannier, Mathilde Chaineau, Lale Gursu, Ghazal Haghi, Anna Kristyna Franco Flores, Guy Rouleau, Thomas M. Durcan, Stefano Stifani
Publikováno v:
Cells, Vol 11, Iss 3, p 399 (2022)
Astrocytes play important roles in the function and survival of neuronal cells. Dysfunctions of astrocytes are associated with numerous disorders and diseases of the nervous system, including motor neuron diseases such as amyotrophic lateral sclerosi
Externí odkaz:
https://doaj.org/article/1c9003b2b9d34989be05ca32ddda5ccc
Publikováno v:
Molecular Oncology, Vol 12, Iss 6, Pp 775-787 (2018)
Glioblastoma (GBM) is the most common and deadly malignant brain cancer of glial cell origin, with a median patient survival of less than 20 months. Transcription factors FOXG1 and TLE1 promote GBM propagation by supporting maintenance of brain tumou
Externí odkaz:
https://doaj.org/article/9b68a180d65c451da2846152d004f99b
Autor:
Stefano Stifani
Publikováno v:
Biomolecules, Vol 8, Iss 4, p 112 (2018)
Peptidyl prolyl isomerases (PPIases) are broadly expressed enzymes that accelerate the cis-trans isomerization of proline peptide bonds. The most extensively studied PPIase family member is protein interacting with never in mitosis A1 (PIN1), which i
Externí odkaz:
https://doaj.org/article/b656ce2040f14a6ab191f3c478e9ef29
Autor:
Gilson S. Baia, Stefano Stifani, Edna T. Kimura, Michael W. McDermott, Russell O. Pieper, Anita Lal
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 6, Pp 604-612 (2008)
The Notch signaling cascade is deregulated in diverse cancer types. Specific Notch function in cancer is dependent on the cellular context, the particular homologs expressed, and cross-talk with other signaling pathways. We have previously shown that
Externí odkaz:
https://doaj.org/article/16d64700389d4e06a497f2288466fcdd