Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Stefano Patassini"'
Autor:
Sasha A. Philbert, Jingshu Xu, Melissa Scholefield, Stefano Patassini, Stephanie J. Church, Richard D. Unwin, Federico Roncaroli, Garth J. S. Cooper
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionVascular dementia (VaD) is one of the most common causes of dementia among the elderly. Despite this, the molecular basis of VaD remains poorly characterized when compared to other age-related dementias. Pervasive cerebral elevations of u
Externí odkaz:
https://doaj.org/article/7512390f6448457da5107a8761bc0857
Autor:
Uxue Ulanga, Matthew Russell, Stefano Patassini, Julie Brazzatti, Ciaren Graham, Anthony D. Whetton, Robert L. J. Graham
Publikováno v:
Scientific Data, Vol 8, Iss 1, Pp 1-9 (2021)
Measurement(s) database type spectral library • protein expression data Technology Type(s) liquid chromatography-electrospray ionisation time-of-flight mass spectrometry • SWATH MS protein profiling assay Factor Type(s) treatment • cell develop
Externí odkaz:
https://doaj.org/article/54e7bcbfac984e3281d176b95c2adb5f
Autor:
Melissa Scholefield, Stephanie J. Church, Jingshu Xu, Stefano Patassini, Federico Roncaroli, Nigel M. Hooper, Richard D. Unwin, Garth J. S. Cooper
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Widespread elevations in brain urea have, in recent years, been reported in certain types of age-related dementia, notably Alzheimer’s disease (AD) and Huntington’s disease (HD). Urea increases in these diseases are substantive, and approximate i
Externí odkaz:
https://doaj.org/article/19001ef99efe4d14957c087415473dbc
Autor:
Melissa Scholefield, Stephanie J. Church, Jingshu Xu, Stefano Patassini, Federico Roncaroli, Nigel M. Hooper, Richard D. Unwin, Garth J. S. Cooper
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Several studies of Parkinson's disease (PD) have reported dysregulation of cerebral metals, particularly decreases in copper and increases in iron in substantia nigra (SN). However, few studies have investigated regions outside the SN, fewer have mea
Externí odkaz:
https://doaj.org/article/c771a8427ef54805a19961581ac0aefb
Autor:
Melissa Scholefield, Stephanie J. Church, Jingshu Xu, Stefano Patassini, Nigel M. Hooper, Richard D. Unwin, Garth J. S. Cooper
Publikováno v:
Metabolites, Vol 11, Iss 9, p 569 (2021)
Pantothenic acid (vitamin B5) is an essential trace nutrient required for the synthesis of coenzyme A (CoA). It has previously been shown that pantothenic acid is significantly decreased in multiple brain regions in both Alzheimer’s disease (ADD) a
Externí odkaz:
https://doaj.org/article/c478ab4f1e094e158574b5baa876cff0
Autor:
Menno H Schut, Stefano Patassini, Eric H Kim, Jocelyn Bullock, Henry J Waldvogel, Richard L M Faull, Barry A Pepers, Johan T den Dunnen, Gert-Jan B van Ommen, Willeke M C van Roon-Mom
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178556 (2017)
Huntington disease is associated with elongation of a CAG repeat in the HTT gene that results in a mutant huntingtin protein. Several studies have implicated N-terminal huntingtin protein fragments in Huntington disease pathogenesis. Ideally, these f
Externí odkaz:
https://doaj.org/article/9a7865e958a0411b9180dd6c69cff94c
Autor:
Franziska Richter, Fuying Gao, Vera Medvedeva, Patrick Lee, Nicholas Bove, Sheila M. Fleming, Magali Michaud, Vincent Lemesre, Stefano Patassini, Krystal De La Rosa, Caitlin K. Mulligan, Pedrom C. Sioshansi, Chunni Zhu, Giovanni Coppola, Thierry Bordet, Rebecca M. Pruss, Marie-Françoise Chesselet
Publikováno v:
Neurobiology of Disease, Vol 69, Iss , Pp 263-275 (2014)
Cholesterol-oximes TRO19622 and TRO40303 target outer mitochondrial membrane proteins and have beneficial effects in preclinical models of neurodegenerative diseases leading to their advancement to clinical trials. Dopaminergic neurons degenerate in
Externí odkaz:
https://doaj.org/article/531ae7518be84ee081e744d1a6aa023f
Autor:
Stefano Patassini, Paul Begley, Jingshu Xu, Stephanie J. Church, Nina Kureishy, Suzanne J. Reid, Henry J. Waldvogel, Richard L. M. Faull, Russell G. Snell, Richard D. Unwin, Garth J. S. Cooper
Publikováno v:
Metabolites, Vol 9, Iss 6, p 113 (2019)
Huntington’s disease (HD) is a neurodegenerative disorder caused by an expanded CAG repeat in exon 1 of the HTT gene. HD usually manifests in mid-life with loss of GABAergic projection neurons from the striatum accompanied by progressive atrophy of
Externí odkaz:
https://doaj.org/article/14ecf4db38ce4f1f8867a6780060e37d
Autor:
Carmela Giampà, Stefano Patassini, Antonella Borreca, Daunia Laurenti, Fabrizia Marullo, Giorgio Bernardi, Frank S. Menniti, Francesca R. Fusco
Publikováno v:
Neurobiology of Disease, Vol 34, Iss 3, Pp 450-456 (2009)
Decreased activity of cAMP responsive element-binding protein (CREB) is thought to contribute to the death of striatal medium spiny neurons in Huntington's disease (HD). Therefore, therapies that increase levels of activated CREB, may be effective in
Externí odkaz:
https://doaj.org/article/4814046872504ea1bbcb03c445236dc1
Publikováno v:
Neurobiology of Disease, Vol 30, Iss 3, Pp 375-387 (2008)
We have previously showed that rolipram, a phosphodiesterase type IV inhibitor, displays a neuroprotective effect in a rat quinolinic acid model of HD [DeMarch Z., Giampa C., Patassini S., Martorana A., Bernardi G. and Fusco F.R., (2007) Beneficial e
Externí odkaz:
https://doaj.org/article/9bb495946e0641c4bac5e64cad00ccca