Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Stefano Minguzzi"'
Autor:
Iga Jakobowska, Frank Becker, Stefano Minguzzi, Kerrin Hansen, Björn Henke, Nathan Hugo Epalle, Eric Beitz, Stefan Hannus
Publikováno v:
Pharmaceuticals, Vol 14, Iss 8, p 757 (2021)
Blocking lactate export in the parasitic protozoan Plasmodium falciparum is a novel strategy to combat malaria. We discovered small drug-like molecules that inhibit the sole plasmodial lactate transporter, PfFNT, and kill parasites in culture. The pe
Externí odkaz:
https://doaj.org/article/5aa87a5ca06b4543a7a20fec80386a82
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146515 (2016)
Many efforts have been made to develop a rapid and sensitive method for phytoplasma and virus detection. Taking our cue from previous works, different rapid sample preparation methods have been tested and applied to Candidatus Phytoplasma prunorum ('
Externí odkaz:
https://doaj.org/article/ddbca4a55bdd45bdbf583578680be16d
Autor:
Andrzej Gondela, Marcin Leś, Maciej Mikulski, Łukasz Włoszczak, Frank Becker, Kamila Olech, Shivapriya Ramaswamy, Marcin Król, Henryk Pawlik, Christian Herhaus, Jose Alvarez, Joanna Szczęśniak, Heike Schilke, Paulina Niedziejko, Lindsey Crowley, Roberta Ferretti, Mireille Krier, Pamela Wahra, Pia Böpple, Timo Heinrich, Justyna Martyka, Ewa Sitek, Karol Zuchowicz, Ada Sala-Hojman, Anna Bartosik, Stefano Minguzzi, Łukasz Dudek, Frank Czauderna, Mateusz Nowak, Ansgar Wegener, Michal Galezowski, Carl Petersson, Sven Jäckel
Publikováno v:
Journal of medicinal chemistry. 64(16)
Due to increased lactate production during glucose metabolism, tumor cells heavily rely on efficient lactate transport to avoid intracellular lactate accumulation and acidification. Monocarboxylate transporter 4 (MCT4/SLC16A3) is a lactate transporte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87d3f6d43a88e3759b7bf441af1e7dd6
https://pubmed.ncbi.nlm.nih.gov/34382802
https://pubmed.ncbi.nlm.nih.gov/34382802
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1875
Most of the molecular diagnostic protocols used for phytoplasmas detection are based on the purification of total nucleic acids and on the use of genomic DNA of the pathogen as the target of amplification. Here we describe a diagnostic approach that,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f2cab8ed163bb7a2309f4ba0b64458ff
https://pubmed.ncbi.nlm.nih.gov/30362003
https://pubmed.ncbi.nlm.nih.gov/30362003
Publikováno v:
Phytopathogenic Mollicutes. 9:83
When high numbers of analyses are required a rapid sample preparation method coupled to RT-qPCR allows to reduce the time and the costs for the phytoplasma detection in plant samples. A comparison between DNA and RNA contribution to qPCR detection re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ee127780d06ff12f7834e92c4e5495
https://doi.org/10.5958/2249-4677.2019.00042.2
https://doi.org/10.5958/2249-4677.2019.00042.2
Publikováno v:
Human Mutation. 35:96-104
Maternal folate levels and polymorphisms in folate-related genes are known risk factors for neural tube defects (NTDs). SNPs in the mitochondrial folate gene MTHFD1L are associated with the risk of NTDs. We investigated whether different alleles of S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8e2265081ee73c30d3894c63b6f472
https://doi.org/10.1002/humu.22459
https://doi.org/10.1002/humu.22459
Autor:
Anne Parle-McDermott, Ciarán Ó'Fágáin, Kirsty K. O'Brien, Nadia Ben Larbi, Stefano Minguzzi, Christine E. Loscher, Gráinne McEntee
Publikováno v:
Proceedings of the National Academy of Sciences. 108:15157-15162
Human dihydrofolate reductase (DHFR) was previously thought to be the only enzyme capable of the reduction of dihydrofolate to tetrahydrofolate; an essential reaction necessary to ensure a continuous supply of biologically active folate. DHFR has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a384afe8e70ff92ae57911fbefd8f68
https://doi.org/10.1073/pnas.1103605108
https://doi.org/10.1073/pnas.1103605108
Autor:
Stefano Minguzzi, Linda Hughes, Robert Carton, Gráinne McEntee, Eva E. Deinum, Mary J. O'Connell, Anne Parle-McDermott
Publikováno v:
FEBS letters. 589(15)
The identification of a second functional dihydrofolate reductase enzyme in humans, DHFRL1, led us to consider whether this is also a feature of rodents. We demonstrate that dihydrofolate reductase activity is also a feature of the mitochondria in bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd408a149bb0cd3f0b497540d47f79f5
https://pubmed.ncbi.nlm.nih.gov/25980602
https://pubmed.ncbi.nlm.nih.gov/25980602
Autor:
Faith Pangilinan, Stefano Minguzzi, Anne M. Molloy, Kirke Peadar, Anne Parle-McDermott, John M. Scott, Lawrence C. Brody, James Troendle, James L. Mills
Publikováno v:
BMC Medical Genetics, Vol 13, Iss 1, p 29 (2012)
BMC Medical Genetics
BMC Medical Genetics
Background Polymorphisms within the MTHFD1L gene were previously associated with risk of neural tube defects in Ireland. We sought to test the most significant MTHFD1L polymorphisms for an association with risk of cleft in an Irish cohort. This requi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e75dd050e96732be020d4b4b10d4d37