Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Stefano Marenco"'
Autor:
Gauri G. Shastri, Gustavo Sudre, Kwangmi Ahn, Benjamin Jung, Bhaskar Kolachana, Pavan K. Auluck, Laura Elnitski, Stefano Marenco, Philip Shaw
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract While epigenetic modifications have been implicated in ADHD through studies of peripheral tissue, to date there has been no examination of the epigenome of the brain in the disorder. To address this gap, we mapped the methylome of the caudat
Externí odkaz:
https://doaj.org/article/2c32eceaeaf948eab815ff3f112ba7c8
Autor:
Anton Schulmann, Stefano Marenco, Marquis P. Vawter, Nirmala Akula, Agenor Limon, Ajeet Mandal, Pavan K. Auluck, Yash Patel, Barbara K. Lipska, Francis J. McMahon
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Recent postmortem transcriptomic studies of schizophrenia (SCZ) have shown hundreds of differentially expressed genes. However, the extent to which these gene expression changes reflect antipsychotic drug (APD) exposure remains uncertain. We
Externí odkaz:
https://doaj.org/article/6c8d3909b4f74186bcb9e6b84c0ae689
Autor:
Lide Han, Xuefang Zhao, Mary Lauren Benton, Thaneer Perumal, Ryan L. Collins, Gabriel E. Hoffman, Jessica S. Johnson, Laura Sloofman, Harold Z. Wang, Matthew R. Stone, CommonMind Consortium, Kristen J. Brennand, Harrison Brand, Solveig K. Sieberts, Stefano Marenco, Mette A. Peters, Barbara K. Lipska, Panos Roussos, John A. Capra, Michael Talkowski, Douglas M. Ruderfer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Structural variants (SVs) contribute to the genetic architecture of many brain-related disorders. Here, the authors integrate SV calls from genome sequencing (n = 755) with RNA-seq data (n = 629) from post-mortem dorsal lateral prefrontal cortex to a
Externí odkaz:
https://doaj.org/article/d5da8027a19c4487875263a8dbf5c81b
Autor:
Sergio Espeso-Gil, Tobias Halene, Jaroslav Bendl, Bibi Kassim, Gabriella Ben Hutta, Marina Iskhakova, Neda Shokrian, Pavan Auluck, Behnam Javidfar, Prashanth Rajarajan, Sandhya Chandrasekaran, Cyril J. Peter, Alanna Cote, Rebecca Birnbaum, Will Liao, Tyler Borrman, Jennifer Wiseman, Aaron Bell, Michael J. Bannon, Panagiotis Roussos, John F. Crary, Zhiping Weng, Stefano Marenco, Barbara Lipska, Nadejda M. Tsankova, Laura Huckins, Yan Jiang, Schahram Akbarian
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-19 (2020)
Abstract Background Midbrain dopaminergic neurons (MDN) represent 0.0005% of the brain’s neuronal population and mediate cognition, food intake, and metabolism. MDN are also posited to underlay the neurobiological dysfunction of schizophrenia (SCZ)
Externí odkaz:
https://doaj.org/article/12c3984af6c44601a2a73a399133c309
Autor:
Jessica L Reed, Enrico D'Ambrosio, Stefano Marenco, Gianluca Ursini, Amanda B Zheutlin, Giuseppe Blasi, Barbara E Spencer, Raffaella Romano, Jesse Hochheiser, Ann Reifman, Justin Sturm, Karen F Berman, Alessandro Bertolino, Daniel R Weinberger, Joseph H Callicott
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195189 (2018)
Brain phenotypes showing environmental influence may help clarify unexplained associations between urban exposure and psychiatric risk. Heritable prefrontal fMRI activation during working memory (WM) is such a phenotype. We hypothesized that urban up
Externí odkaz:
https://doaj.org/article/fddfed3bbec74197a3e9224ec858b895
Autor:
Laramie Duncan, Hanyang Shen, Anton Schulmann, Tayden Li, Bhaskar Kolachana, Ajeet Mandal, Ningping Feng, Pavan Auluck, Stefano Marenco
Publikováno v:
Neuropsychopharmacology. 48:764-772
A new era of human postmortem tissue research has emerged thanks to the development of ‘omics technologies that measure genes, proteins, and spatial parameters in unprecedented detail. Also newly possible is the ability to construct polygenic score
Autor:
Gustavo Sudre, Derek E. Gildea, Gauri G. Shastri, Wendy Sharp, Benjamin Jung, Qing Xu, Pavan K. Auluck, Laura Elnitski, Andreas D. Baxevanis, Stefano Marenco, Philip Shaw
Publikováno v:
Molecular Psychiatry. 28:792-800
Despite advances in identifying rare and common genetic variants conferring risk for ADHD, the lack of a transcriptomic understanding of cortico-striatal brain circuitry has stymied a molecular mechanistic understanding of this disorder. To address t
Autor:
Billy Kim, Dowon Kim, Anton Schulmann, Yash Patel, Carolina Caban-Rivera, Paul Kim, Ananya Jambhale, Kory R. Johnson, Ningping Feng, Qing Xu, Sun Jung Kang, Ajeet Mandal, Michael Kelly, Nirmala Akula, Francis J. McMahon, Barbara Lipska, Stefano Marenco, Pavan K. Auluck
Regional cellular heterogeneity is a fundamental feature of the human neocortex; however, details of this heterogeneity are still undefined. We used single-nucleus RNA-sequencing to examine cell-specific transcriptional features in the dorsolateral P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d482d97f72c01fcf6e50427a917c208
Autor:
Biao Zeng, Jaroslav Bendl, Chengyu Deng, Donghoon Lee, Ruth Misir, Sarah M. Reach, Steven P. Kleopoulos, Pavan Auluck, Stefano Marenco, David A. Lewis, Vahram Haroutunian, Nadav Ahituv, John F. Fullard, Gabriel E. Hoffman, Panos Roussos
Nucleotide variants in cell type-specific gene regulatory elements in the human brain are major risk factors of human disease. We measured chromatin accessibility in sorted neurons and glia from 1,932 samples of human postmortem brain and identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77d92cb067b31030eb4fbee22de506be
https://doi.org/10.1101/2023.03.02.530826
https://doi.org/10.1101/2023.03.02.530826
Autor:
Kiran, Girdhar, Gabriel E, Hoffman, Jaroslav, Bendl, Samir, Rahman, Pengfei, Dong, Will, Liao, Mads E, Hauberg, Laura, Sloofman, Leanne, Brown, Olivia, Devillers, Bibi S, Kassim, Jennifer R, Wiseman, Royce, Park, Elizabeth, Zharovsky, Rivky, Jacobov, Elie, Flatow, Alexey, Kozlenkov, Thomas, Gilgenast, Jessica S, Johnson, Lizette, Couto, Mette A, Peters, Jennifer E, Phillips-Cremins, Chang-Gyu, Hahn, Raquel E, Gur, Carol A, Tamminga, David A, Lewis, Vahram, Haroutunian, Stella, Dracheva, Barbara K, Lipska, Stefano, Marenco, Marija, Kundakovic, John F, Fullard, Yan, Jiang, Panos, Roussos, Schahram, Akbarian
Publikováno v:
Girdhar, K, Hoffman, G E, Bendl, J, Rahman, S, Dong, P, Liao, W, Hauberg, M E, Sloofman, L, Brown, L, Devillers, O, Kassim, B S, Wiseman, J R, Park, R, Zharovsky, E, Jacobov, R, Flatow, E, Kozlenkov, A, Gilgenast, T, Johnson, J S, Couto, L, Peters, M A, Phillips-Cremins, J E, Hahn, C G, Gur, R E, Tamminga, C A, Lewis, D A, Haroutunian, V, Dracheva, S, Lipska, B K, Marenco, S, Kundakovic, M, Fullard, J F, Jiang, Y, Roussos, P, Akbarian, S & PsychENCODE Consortium 2022, ' Chromatin domain alterations linked to 3D genome organization in a large cohort of schizophrenia and bipolar disorder brains ', Nature Neuroscience, vol. 25, no. 4, pp. 474-483 . https://doi.org/10.1038/s41593-022-01032-6
Chromosomal organization, scaling from the 147-base pair (bp) nucleosome to megabase-ranging domains encompassing multiple transcriptional units, including heritability loci for psychiatric traits, remains largely unexplored in the human brain. In th