Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Stefano Longobardi"'
Autor:
Cristobal Rodero, Marina Strocchi, Maciej Marciniak, Stefano Longobardi, John Whitaker, Mark D O'Neill, Karli Gillette, Christoph Augustin, Gernot Plank, Edward J Vigmond, Pablo Lamata, Steven A Niederer
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 5, p e1010196 (2022)
[This corrects the article DOI: 10.1371/journal.pcbi.1008851.].
Externí odkaz:
https://doaj.org/article/6409a5cec0d8491d81c8d39895020613
Autor:
Damiano Fassina, Caroline M Costa, Stefano Longobardi, Elias Karabelas, Gernot Plank, Sian E Harding, Steven A Niederer
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 4, p e1010030 (2022)
Application of epicardial patches constructed from human-induced pluripotent stem cell- derived cardiomyocytes (hiPSC-CMs) has been proposed as a long-term therapy to treat scarred hearts post myocardial infarction (MI). Understanding electrical inte
Externí odkaz:
https://doaj.org/article/5fbdad1b48774d249685a288a0322e37
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 12, p e1009646 (2021)
Heart failure with preserved ejection fraction (HFpEF) is a complex disease associated with multiple co-morbidities, where impaired cardiac mechanics are often the end effect. At the cellular level, cardiac mechanics can be pharmacologically manipula
Externí odkaz:
https://doaj.org/article/b8b15d0b75044eefa8f3abbc12f64f5c
Autor:
Cristobal Rodero, Marina Strocchi, Maciej Marciniak, Stefano Longobardi, John Whitaker, Mark D O'Neill, Karli Gillette, Christoph Augustin, Gernot Plank, Edward J Vigmond, Pablo Lamata, Steven A Niederer
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 4, p e1008851 (2021)
Cardiac anatomy plays a crucial role in determining cardiac function. However, there is a poor understanding of how specific and localised anatomical changes affect different cardiac functional outputs. In this work, we test the hypothesis that in a
Externí odkaz:
https://doaj.org/article/2d7ba169e8be4c0eb71d0d60f5b652c3
Publikováno v:
The Journal of Physiology. 600:3497-3516
The force-pCa (F-pCa) curve is used to characterize steady-state contractile properties of cardiac muscle cells in different physiological, pathological and pharmacological conditions. This provides a reduced preparation in which to isolate sarcomere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745b1d640212201e0ae8b0a99f484a66
https://doi.org/10.1113/jp283352
https://doi.org/10.1113/jp283352
Autor:
Cristobal Rodero, Stefano Longobardi, Christoph Augustin, Marina Strocchi, Gernot Plank, Pablo Lamata, Steven A. Niederer
Publikováno v:
Annals of biomedical engineering.
Previous patient-specific model calibration techniques have treated each patient independently, making the methods expensive for large-scale clinical adoption. In this work, we show how we can reuse simulations to accelerate the patient-specific mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b57881ab0be82900c4f6219a2eabdd6
https://pubmed.ncbi.nlm.nih.gov/36271218
https://pubmed.ncbi.nlm.nih.gov/36271218
Autor:
Marina Strocchi, Stefano Longobardi, Christoph M. Augustin, Matthias A. F. Gsell, Edward J. Vigmond, Gernot Plank, Chris J. Oates, Richard D. Wilkinson, Steven A. Niederer
Publikováno v:
MATHMOD 2022 Discussion Contribution Volume.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b0691b1063f6f455396b2505a860412
https://doi.org/10.11128/arep.17.a17078
https://doi.org/10.11128/arep.17.a17078
Publikováno v:
Functional Imaging and Modeling of the Heart ISBN: 9783030787097
FIMH
FIMH
Omecamtiv mecarbil (OM) is a cardiac myosin activator developed as a treatment of heart failure. OM acts on cross-bridge formation without disrupting intracellular calcium homeostasis. OM effects are extensively characterised both in vitro and in viv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d06915a0c992c12fffea65638950fd0
https://doi.org/10.1007/978-3-030-78710-3_39
https://doi.org/10.1007/978-3-030-78710-3_39
Modelling the Effects of Conductive Polymers and Stem Cells Derived Myocytes on Scarred Heart Tissue
Autor:
Damiano Fassina, Caroline Mendonca Costa, Stefano Longobardi, Sian E. Harding, Steven A. Niederer
Publikováno v:
CinC
Myocardial infarction leads to permanent tissue scars that impairs cardiac function and can result in heart failure. The use of engineered heart tissue (EHT) and conductive polymers (CP) in regenerative medicine aims to assist tissue recovery and imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::009b6b95e5549ca3eaf10cd63cafea77
https://doi.org/10.22489/cinc.2020.223
https://doi.org/10.22489/cinc.2020.223
Autor:
Stefano Longobardi, Ronak Rajani, Marina Strocchi, Christopher A. Rinaldi, Steven A. Niederer, Baldeep S. Sidhu, Orod Razeghi, Angela W.C. Lee, Justin Gould, Jonathan M. Behar
Publikováno v:
Journal of cardiovascular electrophysiologyREFERENCES. 31(9)
Background Leadless pacemakers preclude the need for permanent leads to pace endocardium. However, it is yet to be determined whether a leadless pacemaker of a similar design to those manufactured for the right ventricle (RV) fits within the left ven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08088f86e30c1600f957a995c6ff2b1d
https://pubmed.ncbi.nlm.nih.gov/32639621
https://pubmed.ncbi.nlm.nih.gov/32639621