Výsledky vyhledávání - "Stefano Lazzarano"

Akademický článek

High-Throughput Identification of MiR-145 Targets in Human Articular Chondrocytes

Autor: Aida Martinez-Sanchez, Stefano Lazzarano, Eshita Sharma, Helen Lockstone, Christopher L. Murphy

Publikováno v: Life, Vol 10, Iss 5, p 58 (2020)

MicroRNAs (miRNAs) play key roles in cartilage development and homeostasis and are dysregulated in osteoarthritis. MiR-145 modulation induces profound changes in the human articular chondrocyte (HAC) phenotype, partially through direct repression of

Externí odkaz: https://doaj.org/article/262ce94267844c8a8af124f505bf83c6

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High-Throughput Identification of MiR-145 Targets in Human Articular Chondrocytes

Autor: Helen Lockstone, Aida Martinez-Sanchez, Eshita Sharma, Christopher L. Murphy, Stefano Lazzarano

Publikováno v: Life, Vol 10, Iss 58, p 58 (2020)
Life
Volume 10
Issue 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3fbddf6f0d8dec02a8290f95776bc3
https://www.mdpi.com/2075-1729/10/5/58

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High through-put identification of miR-145 targets in human articular chondrocytes

Autor: Aida Martinez-Sanchez, Stefano Lazzarano, Eshita Sharma, Christopher L. Murphy

ObjectiveMicroRNAs play a key role in biological processes, including cartilage development and homeostasis and are dysregulated in many diseases, including osteoarthritis. MiR-145 modulation induces profound changes in the human articular chondrocyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::807c443a97dbb64d477a9a043bdd1ab2

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MEF2C is a new regulator of the human articular chondrocyte phenotype

Autor: Christopher L. Murphy, Stefano Lazzarano

MEF2C plays a role in diverse tissues, most notably heart, brain, eyes and developing bones. Here we report for the first time that MEF2C is present and active in the permanent articular cartilage in humans which lines and protects our joints through

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3c3d60f89fb680f6c1602977a5e701

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Genetic mapping of species differences via in vitro crosses in mouse embryonic stem cells

Autor: Stefano Lazzarano, Marek Kučka, Claude Libert, Michael N. C. Fletcher, Tino Hochepied, Ronald Naumann, Paloma Medina, Rebecka Wombacher, Marc Van Montagu, Yingguang Frank Chan, Joao P. L. Castro, Joost Gribnau

Publikováno v: Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of Ame, 115(14), 3680-3685. National Academy of Sciences
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Significance How species differ from each other is a key question in biology. However, genetic mapping between species often fails because of sterile hybrid crosses. Here, we have developed a technique called in vitro recombination to circumvent bree

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad0eeec922c65da085413314c86e9cc

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Genetic mapping of species differences via 'in vitrocrosses' in mouse embryonic stem cells

Autor: Rebecka Wombacher, Claude Libert, Marek Kučka, Joost Gribnau, Yingguang Frank Chan, Tino Hochepied, Paloma Medina, Ronald Naumann, Michael N. C. Fletcher, Stefano Lazzarano, Joao P. L. Castro

Discovering the genetic changes underlying species differences is a central goal in evolutionary genetics. However, hybrid crosses between species in mammals often suffer from hybrid sterility, greatly complicating genetic dissection of trait variati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7474eb5d9cde1e32f4fa3190f14e19e5
https://doi.org/10.1101/148486

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Parathyroid hormone-related protein is induced by hypoxia and promotes expression of the differentiated phenotype of human articular chondrocytes

Autor: Christopher L. Murphy, Stefano Lazzarano, Michele Pelosi, Brendan L. Thoms

Publikováno v: Clinical Science. 125:461-470

PTHrP (parathyroid hormone-related protein) is crucial for normal cartilage development and long bone growth and acts to delay chondrocyte hypertrophy and terminal differentiation in the growth plate. After growth plate closure adult HACs (human arti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b05aee617945e4155bd38d9eec2275b7
https://doi.org/10.1042/cs20120610

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Transgene traceability in transgenic mice: a bioanalytical approach for potential gene-doping analysis

Autor: Marcello Buiatti, Maria Minunni, Annarosa Arcangeli, Patrizia Bogani, Stefano Lazzarano, Maria Michela Spiriti

Publikováno v: Bioanalysis. 3(22)

Background: The World Anti-Doping Agency fears the use of gene doping to enhance athletic performances. Thus, a bioanalytical approach based on end point PCR for detecting markers’ of transgenesis traceability was developed. Results: A few sequence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6988cc4b309704fc06012d917897793b
https://pubmed.ncbi.nlm.nih.gov/22122601

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